The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer

Hypoxia regulates key biological processes including angiogenesis via the transcription factor, hypoxia-inducible factor (HIF). In prostate cancer, angiogenesis is also influenced by androgens, and recent cell line studies suggest that this effect is partly mediated by HIF. The study aimed to assess...

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Veröffentlicht in:	Clinical cancer research Jg. 11; H. 21; S. 7658
Hauptverfasser:	Boddy, Jane L, Fox, Stephen B, Han, Cheng, Campo, Leticia, Turley, Helen, Kanga, Suresh, Malone, Peter R, Harris, Adrian L
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.11.2005
Schlagworte:	Aged Basic Helix-Loop-Helix Transcription Factors - biosynthesis Disease Progression Disease-Free Survival Gene Expression Regulation, Neoplastic Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis Immunohistochemistry Male Middle Aged Models, Statistical Neovascularization, Pathologic Procollagen-Proline Dioxygenase - biosynthesis Proportional Hazards Models Prostate-Specific Antigen - biosynthesis Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Receptors, Androgen - biosynthesis Recurrence Vascular Endothelial Growth Factor A - biosynthesis Vascular Endothelial Growth Factor A - metabolism
ISSN:	1078-0432
Online-Zugang:	Weitere Angaben
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