Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury

Acetaminophen ( -acetyl- -aminophenol; APAP) toxicity is a common cause of liver damage. In the mouse model of APAP-induced liver injury (AILI), interleukin 11 (IL11) is highly up-regulated and administration of recombinant human IL11 (rhIL11) has been shown to be protective. Here, we demonstrate th...

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Veröffentlicht in:	Science translational medicine Jg. 13; H. 597
Hauptverfasser:	Widjaja, Anissa A, Dong, Jinrui, Adami, Eleonora, Viswanathan, Sivakumar, Ng, Benjamin, Pakkiri, Leroy S, Chothani, Sonia P, Singh, Brijesh K, Lim, Wei Wen, Zhou, Jin, Shekeran, Shamini G, Tan, Jessie, Lim, Sze Yun, Goh, Joyce, Wang, Mao, Holgate, Robert, Hearn, Arron, Felkin, Leanne E, Yen, Paul M, Dear, James W, Drum, Chester L, Schafer, Sebastian, Cook, Stuart A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 09.06.2021
Schlagworte:	Acetaminophen - toxicity Animals Chemical and Drug Induced Liver Injury - drug therapy Chemical and Drug Induced Liver Injury, Chronic Hepatocytes Interleukin-11 Interleukin-11 Receptor alpha Subunit Liver Mice Mice, Inbred C57BL
ISSN:	1946-6242, 1946-6242
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