Fluselenamyl: Evaluation of radiation dosimetry in mice and pharmacokinetics in brains of non-human primate

To allow quantitative assessment of therapeutic efficacy for therapeutic interventions (either approved or undergoing FDA approvals) for either inhibiting or reducing development of Aβ pathophysiology in vivo, 18F-labelled tracers, such as Florbetapir, Florbetaben, and Flutemetamol have been approve...

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Veröffentlicht in:	Nuclear medicine and biology Jg. 82-83; S. 33 - 40
Hauptverfasser:	Sundaram, G.S.M., Jones, Lynne, Zhou, Yun, Laforest, Richard, Sharma, Vijay
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 01.03.2020 Elsevier BV
Schlagworte:	Algorithms Amyloid Animals Background levels Blood-brain barrier Brain Brain - diagnostic imaging Brain - metabolism Cerebellum Constraint modelling Dosimeters Dosimetry Euthanasia Evaluation Female Females Fluorine isotopes Gallbladder Gender Imaging Injection Intravenous administration Macaca mulatta Magnetic Resonance Imaging Male Males Mice Neostriatum Neuroimaging Organs Pathophysiology Pharmacokinetics Pharmacology Positron emission Positron emission tomography Primates Radiation dosage Radiation dosimetry Radiochemistry Radiometry Rodents Senile plaques Substantia alba Thalamus Therapeutic applications Tissue Distribution Tomography Tracers Transport rate
ISSN:	0969-8051, 1872-9614, 1872-9614
Online-Zugang:	Volltext
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