Confined Bilayers Passively Regulate Shape and Stress

Lipid membranes are commonly confined to adjacent subcellular structures or to artificial substrates and particles. We develop an experimental and theoretical framework to investigate the mechanics of confined membranes, including the influence of adhesion, strain, and osmotic pressure. We find that...

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Bibliographic Details
Published in:Physical review letters Vol. 110; no. 2; p. 028101
Main Authors: Staykova, Margarita, Arroyo, Marino, Rahimi, Mohammad, Stone, Howard A.
Format: Journal Article Publication
Language:English
Published: United States 11.01.2013
Subjects:
90 Operations research, mathematical programming
90B Operations research and management science
92 Biology and other natural sciences
92C Physiological, cellular and medical topics
Biologia
Biology
Cell Adhesion - physiology
Cell Membrane - chemistry
Cell Membrane - physiology
Classificació AMS
Investigació operativa
Lipid Bilayers - chemistry
Matemàtica aplicada a les ciències
Matemàtiques i estadística
Models, Biological
Models, Chemical
Models, Theoretical
Operations research
Osmosis
Programació matemàtica
Thermodynamics
Àrees temàtiques de la UPC
ISSN:0031-9007, 1079-7114, 1079-7114
Online Access:Get full text
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Summary:Lipid membranes are commonly confined to adjacent subcellular structures or to artificial substrates and particles. We develop an experimental and theoretical framework to investigate the mechanics of confined membranes, including the influence of adhesion, strain, and osmotic pressure. We find that supported lipid bilayers respond to stress by nucleating and evolving spherical and tubular protrusions. In cells, such transformations are generally attributed to proteins. Our results offer insights into the mechanics of cell membranes and can further extend the applications of supported bilayers.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0031-9007
1079-7114
1079-7114
DOI:10.1103/PhysRevLett.110.028101