Confined Bilayers Passively Regulate Shape and Stress

Lipid membranes are commonly confined to adjacent subcellular structures or to artificial substrates and particles. We develop an experimental and theoretical framework to investigate the mechanics of confined membranes, including the influence of adhesion, strain, and osmotic pressure. We find that...

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Veröffentlicht in:Physical review letters Jg. 110; H. 2; S. 028101
Hauptverfasser: Staykova, Margarita, Arroyo, Marino, Rahimi, Mohammad, Stone, Howard A.
Format: Journal Article Verlag
Sprache:Englisch
Veröffentlicht: United States 11.01.2013
Schlagworte:
90 Operations research, mathematical programming
90B Operations research and management science
92 Biology and other natural sciences
92C Physiological, cellular and medical topics
Biologia
Biology
Cell Adhesion - physiology
Cell Membrane - chemistry
Cell Membrane - physiology
Classificació AMS
Investigació operativa
Lipid Bilayers - chemistry
Matemàtica aplicada a les ciències
Matemàtiques i estadística
Models, Biological
Models, Chemical
Models, Theoretical
Operations research
Osmosis
Programació matemàtica
Thermodynamics
Àrees temàtiques de la UPC
ISSN:0031-9007, 1079-7114, 1079-7114
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Abstract Lipid membranes are commonly confined to adjacent subcellular structures or to artificial substrates and particles. We develop an experimental and theoretical framework to investigate the mechanics of confined membranes, including the influence of adhesion, strain, and osmotic pressure. We find that supported lipid bilayers respond to stress by nucleating and evolving spherical and tubular protrusions. In cells, such transformations are generally attributed to proteins. Our results offer insights into the mechanics of cell membranes and can further extend the applications of supported bilayers.
AbstractList Lipid membranes are commonly confined to adjacent subcellular structures or to artificial substrates and particles. We develop an experimental and theoretical framework to investigate the mechanics of confined membranes, including the influence of adhesion, strain, and osmotic pressure. We find that supported lipid bilayers respond to stress by nucleating and evolving spherical and tubular protrusions. In cells, such transformations are generally attributed to proteins. Our results offer insights into the mechanics of cell membranes and can further extend the applications of supported bilayers.Lipid membranes are commonly confined to adjacent subcellular structures or to artificial substrates and particles. We develop an experimental and theoretical framework to investigate the mechanics of confined membranes, including the influence of adhesion, strain, and osmotic pressure. We find that supported lipid bilayers respond to stress by nucleating and evolving spherical and tubular protrusions. In cells, such transformations are generally attributed to proteins. Our results offer insights into the mechanics of cell membranes and can further extend the applications of supported bilayers.
Lipid membranes are commonly confined to adjacent subcellular structures or to artificial substrates and particles. We develop an experimental and theoretical framework to investigate the mechanics of confined membranes, including the influence of adhesion, strain, and osmotic pressure. We find that supported lipid bilayers respond to stress by nucleating and evolving spherical and tubular protrusions. In cells, such transformations are generally attributed to proteins. Our results offer insights into the mechanics of cell membranes and can further extend the applications of supported bilayers. Peer Reviewed
Lipid membranes are commonly confined to adjacent subcellular structures or to artificial substrates and particles. We develop an experimental and theoretical framework to investigate the mechanics of confined membranes, including the influence of adhesion, strain, and osmotic pressure. We find that supported lipid bilayers respond to stress by nucleating and evolving spherical and tubular protrusions. In cells, such transformations are generally attributed to proteins. Our results offer insights into the mechanics of cell membranes and can further extend the applications of supported bilayers.
ArticleNumber 028101
Author Arroyo, Marino
Stone, Howard A.
Rahimi, Mohammad
Staykova, Margarita
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  surname: Staykova
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  givenname: Mohammad
  surname: Rahimi
  fullname: Rahimi, Mohammad
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  givenname: Howard A.
  surname: Stone
  fullname: Stone, Howard A.
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Cites_doi 10.1007/s002320010040
10.1021/bm200266z
10.1103/PhysRevLett.98.018102
10.1038/nrm1437
10.1021/la700523x
10.1073/pnas.1102358108
10.1085/jgp.200709848
10.1529/biophysj.106.091702
10.1073/pnas.1015892108
10.1016/j.cell.2008.11.028
10.1007/3-540-49522-3
10.1021/la9903043
10.1021/la8033269
10.1103/PhysRevE.63.051911
10.1146/annurev-biochem-052809-155121
10.1016/j.bpj.2011.08.057
10.1038/nrm2453
10.1021/la026236t
10.1016/j.bpj.2010.07.031
10.1088/0953-8984/18/28/S04
10.1016/S0006-3495(00)76294-1
10.1038/nature04396
10.1103/PhysRevE.86.011932
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Contributor Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental
Universitat Politècnica de Catalunya. LACÀN - Mètodes Numèrics en Ciències Aplicades i Enginyeria
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References PhysRevLett.110.028101Cc7R1
E. Morris (PhysRevLett.110.028101Cc10R1) 2001; 179
PhysRevLett.110.028101Cc8R1
PhysRevLett.110.028101Cc9R1
PhysRevLett.110.028101Cc3R1
PhysRevLett.110.028101Cc4R1
PhysRevLett.110.028101Cc5R1
PhysRevLett.110.028101Cc20R1
PhysRevLett.110.028101Cc6R1
PhysRevLett.110.028101Cc22R1
PhysRevLett.110.028101Cc11R1
PhysRevLett.110.028101Cc21R1
PhysRevLett.110.028101Cc1R1
R. Lipowsky (PhysRevLett.110.028101Cc14R1) 2012; 161
PhysRevLett.110.028101Cc24R1
PhysRevLett.110.028101Cc2R1
PhysRevLett.110.028101Cc13R1
PhysRevLett.110.028101Cc23R1
PhysRevLett.110.028101Cc26R1
PhysRevLett.110.028101Cc25R1
PhysRevLett.110.028101Cc28R1
PhysRevLett.110.028101Cc17R1
PhysRevLett.110.028101Cc27R1
PhysRevLett.110.028101Cc29R1
References_xml – volume: 179
  start-page: 79
  issn: 0022-2631
  year: 2001
  ident: PhysRevLett.110.028101Cc10R1
  publication-title: J. Membr. Biol.
  doi: 10.1007/s002320010040
– ident: PhysRevLett.110.028101Cc4R1
  doi: 10.1021/bm200266z
– ident: PhysRevLett.110.028101Cc9R1
  doi: 10.1103/PhysRevLett.98.018102
– ident: PhysRevLett.110.028101Cc1R1
  doi: 10.1038/nrm1437
– ident: PhysRevLett.110.028101Cc5R1
  doi: 10.1021/la700523x
– ident: PhysRevLett.110.028101Cc3R1
  doi: 10.1073/pnas.1102358108
– ident: PhysRevLett.110.028101Cc25R1
  doi: 10.1085/jgp.200709848
– ident: PhysRevLett.110.028101Cc6R1
  doi: 10.1529/biophysj.106.091702
– ident: PhysRevLett.110.028101Cc26R1
  doi: 10.1073/pnas.1015892108
– ident: PhysRevLett.110.028101Cc23R1
  doi: 10.1016/j.cell.2008.11.028
– ident: PhysRevLett.110.028101Cc13R1
  doi: 10.1007/3-540-49522-3
– volume: 161
  start-page: 1
  issn: 1359-6640
  year: 2012
  ident: PhysRevLett.110.028101Cc14R1
  publication-title: Faraday Discuss.
– ident: PhysRevLett.110.028101Cc21R1
  doi: 10.1021/la9903043
– ident: PhysRevLett.110.028101Cc7R1
  doi: 10.1021/la8033269
– ident: PhysRevLett.110.028101Cc11R1
  doi: 10.1103/PhysRevE.63.051911
– ident: PhysRevLett.110.028101Cc28R1
  doi: 10.1146/annurev-biochem-052809-155121
– ident: PhysRevLett.110.028101Cc20R1
  doi: 10.1016/j.bpj.2011.08.057
– ident: PhysRevLett.110.028101Cc8R1
  doi: 10.1038/nrm2453
– ident: PhysRevLett.110.028101Cc22R1
  doi: 10.1021/la026236t
– ident: PhysRevLett.110.028101Cc27R1
  doi: 10.1016/j.bpj.2010.07.031
– ident: PhysRevLett.110.028101Cc29R1
  doi: 10.1088/0953-8984/18/28/S04
– ident: PhysRevLett.110.028101Cc24R1
  doi: 10.1016/S0006-3495(00)76294-1
– ident: PhysRevLett.110.028101Cc2R1
  doi: 10.1038/nature04396
– ident: PhysRevLett.110.028101Cc17R1
  doi: 10.1103/PhysRevE.86.011932
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Snippet Lipid membranes are commonly confined to adjacent subcellular structures or to artificial substrates and particles. We develop an experimental and theoretical...
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SubjectTerms 90 Operations research, mathematical programming
90B Operations research and management science
92 Biology and other natural sciences
92C Physiological, cellular and medical topics
Biologia
Biology
Cell Adhesion - physiology
Cell Membrane - chemistry
Cell Membrane - physiology
Classificació AMS
Investigació operativa
Lipid Bilayers - chemistry
Matemàtica aplicada a les ciències
Matemàtiques i estadística
Models, Biological
Models, Chemical
Models, Theoretical
Operations research
Osmosis
Programació matemàtica
Thermodynamics
Àrees temàtiques de la UPC
Title Confined Bilayers Passively Regulate Shape and Stress
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