Identification and Analysis of Estrogen Receptor α Promoting Tamoxifen Resistance-Related lncRNAs

70-75% breast cancer patients are estrogen receptor alpha positive (ERα+), and the antiestrogen drug tamoxifen has been used for the past three decades. However, in 20-30% of these patients, tamoxifen therapy fails due to intrinsic or acquired resistance. A previous study has showed ERα signaling st...

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Veröffentlicht in:	BioMed research international Jg. 2020; H. 2020; S. 1 - 10
Hauptverfasser:	Wang, Wei, Li, Zhen, Gao, Shanjun, Zhang, Xiulei, Liu, Guangzhi
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Cairo, Egypt Hindawi Publishing Corporation 2020 Hindawi John Wiley & Sons, Inc
Schlagworte:	Antiestrogens Binding sites Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell cycle Chromatin Databases, Nucleic Acid Drug resistance Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism Estrogens Female Genomes Humans Immunoprecipitation Kinases MCF-7 Cells Medical prognosis Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Receptors Recruitment Ribonucleic acid RNA RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism RNA, Neoplasm - genetics RNA, Neoplasm - metabolism Survival analysis Tamoxifen Tamoxifen - pharmacology
ISSN:	2314-6133, 2314-6141, 2314-6141
Online-Zugang:	Volltext
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