Identification and Analysis of Estrogen Receptor α Promoting Tamoxifen Resistance-Related lncRNAs

70-75% breast cancer patients are estrogen receptor alpha positive (ERα+), and the antiestrogen drug tamoxifen has been used for the past three decades. However, in 20-30% of these patients, tamoxifen therapy fails due to intrinsic or acquired resistance. A previous study has showed ERα signaling st...

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Vydáno v:BioMed research international Ročník 2020; číslo 2020; s. 1 - 10
Hlavní autoři: Wang, Wei, Li, Zhen, Gao, Shanjun, Zhang, Xiulei, Liu, Guangzhi
Médium: Journal Article
Jazyk:angličtina
Vydáno: Cairo, Egypt Hindawi Publishing Corporation 2020
Hindawi
John Wiley & Sons, Inc
Témata:
Antiestrogens
Binding sites
Breast cancer
Breast Neoplasms - drug therapy
Breast Neoplasms - genetics
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cell cycle
Chromatin
Databases, Nucleic Acid
Drug resistance
Drug Resistance, Neoplasm - drug effects
Drug Resistance, Neoplasm - genetics
Estrogen Receptor alpha - genetics
Estrogen Receptor alpha - metabolism
Estrogens
Female
Genomes
Humans
Immunoprecipitation
Kinases
MCF-7 Cells
Medical prognosis
Neoplasm Proteins - genetics
Neoplasm Proteins - metabolism
Receptors
Recruitment
Ribonucleic acid
RNA
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
RNA, Neoplasm - genetics
RNA, Neoplasm - metabolism
Survival analysis
Tamoxifen
Tamoxifen - pharmacology
ISSN:2314-6133, 2314-6141, 2314-6141
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Shrnutí:70-75% breast cancer patients are estrogen receptor alpha positive (ERα+), and the antiestrogen drug tamoxifen has been used for the past three decades. However, in 20-30% of these patients, tamoxifen therapy fails due to intrinsic or acquired resistance. A previous study has showed ERα signaling still exerts significant roles in the development of tamoxifen resistance and several lncRNAs have been demonstrated important roles in tamoxifen resistance. But ERα directly regulated and tamoxifen resistance related lncRNAs remain to be discovered. We reanalyze the published ERα chromatin immunoprecipitation-seq (ChIP-seq) and RNA-seq data of tamoxifen-sensitive (MCF-7/WT) and tamoxifen-resistant (MCF-7/TamR) breast cancer cells. We demonstrate that there are differential ERα recruitment events and the differentials may alert the expression profile in MCF-7/WT and MCF-7/TamR cells. Furthermore, we make an overlap of the ERα binding lncRNAs and differentially expressed lncRNAs and get 49 ERα positively regulated lncRNAs. Among these lncRNAs, the expression levels of AC117383.1, AC144450.1, RP11-15H20.6, and ATXN1-AS1 are negatively correlated with the survival probability of breast cancer patients and ELOVL2-AS1, PCOLCE-AS1, ITGA9-AS1, and FLNB-AS1 are positively correlated. These lncRNAs may be potential diagnosis or prognosis markers of tamoxifen resistance.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Academic Editor: Mai S. Li
ISSN:2314-6133
2314-6141
2314-6141
DOI:10.1155/2020/9031723