High plasma leptin levels are associated with impaired diastolic function in patients with coronary artery disease

•High leptin levels are associated with impaired LV diastolic function in CAD.•Leptin may be a mechanistic link between obesity and congestive heart failure.•Leptin may have profibrotic effects and increase collagen in myocardial ECM. Obese subjects have elevated leptin levels, which have been assoc...

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Bibliographic Details
Published in:	Peptides (New York, N.Y. : 1980) Vol. 84; pp. 17 - 21
Main Authors:	Puurunen, V.P., Lepojärvi, E.S., Piira, O.P., Hedberg, P., Junttila, M.J., Ukkola, O., Huikuri, H.V.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.10.2016
Subjects:	Aged Coronary artery disease Coronary Artery Disease - blood Coronary Artery Disease - etiology Coronary Artery Disease - physiopathology Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - pathology Diastole - physiology Diastolic function Echocardiography Female Heart failure Heart Failure - blood Heart Failure - physiopathology Humans Leptin Leptin - blood Male Middle Aged Obesity Obesity - blood Obesity - complications Obesity - pathology patients risk Risk Factors tissues Ventricular Dysfunction, Left - blood Ventricular Dysfunction, Left - etiology Ventricular Dysfunction, Left - physiopathology Diastolic function Heart failure Obesity Coronary artery disease Leptin
ISSN:	0196-9781, 1873-5169
Online Access:	Get full text
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