Structural Characterization and Cardioprotective Effect of Water-Soluble Polysaccharides Extracted from Clematis flammula

Clematis flammula is widely used for its pharmacological properties in Tunisia. This work aimed to explore, in a rat model, the cardiopreventive capacity of polysaccharides extracted from C. flammula (CFPS) after a myocardial injury caused by isoproterenol. Structural analyses suggested that the ave...

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Vydané v:Applied sciences Ročník 12; číslo 21; s. 10818
Hlavní autori: Baaziz, Intissar, Ghazouani, Lakhdar, Rjeibi, Ilhem, Feriani, Anouar, Mnafgui, Kais, Mufti, Afoua, Traikia, Mounir, Le Cerf, Didier, Michaud, Philippe, Pierre, Guillaume, Cherif, Slim
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Basel MDPI AG 01.11.2022
Multidisciplinary digital publishing institute (MDPI)
Predmet:
Apoptosis
cardioprotective
Chemical Sciences
Chromatography
Clematis flammula
genotoxicity
Glucose
Heart
Herbal medicine
Lasers
Molecular weight
myocardial injury
NMR
Nuclear magnetic resonance
polysaccharides
Software
United States > US
Tunisia
Japan
Germany
genotoxicity
polysaccharides
cardioprotective
myocardial injury
Clematis flammula
ISSN:2076-3417, 2076-3417
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Shrnutí:Clematis flammula is widely used for its pharmacological properties in Tunisia. This work aimed to explore, in a rat model, the cardiopreventive capacity of polysaccharides extracted from C. flammula (CFPS) after a myocardial injury caused by isoproterenol. Structural analyses suggested that the average molecular weight of CFPS was 1.82 × 105 g/mol, being mainly composed of glucuronide (41.53%), galacturonic acid (19.06%), arabinose (16.10%), galactose (6.15%), glucose (5.49%), and rhamnose (3.55%). Fourier transform–infrared spectroscopy and nuclear magnetic resonance spectroscopy experiments showed that CFPS was rich with carbohydrates containing pectic materials with glycosidic bonds. In addition, results show that pretreatment with CFPS (150 mg/kg) could improve the electrocardiogram pattern by decreasing the elevated ST segment and ameliorating the relative heart weights and the biochemical profile content (creatine phosphokinase-MB, lactate dehydrogenase, and cardiac troponin I). Furthermore, pretreatment with CFPS reduced the amount of malondialdehyde and restored the genotoxicity induced by isoproterenol. The histopathological study revealed that CFPS pretreatment diminished the level of cardiac tissue injury. Based on these data, CFPS presents a broad biological effect as a cardioprotective and can be used for the exploration of novel natural products for the treatment of cardiac disease.
Bibliografia:ObjectType-Article-1
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ISSN:2076-3417
2076-3417
DOI:10.3390/app122110818