Multiple-Dose Study to Evaluate Pharmacokinetics, Pharmacodynamics, and Safety in Healthy Subjects: A Comparison of Controlled-Release Sarpogrelate and Immediate-Release Sarpogrelate

Aims: To compare the pharmacokinetics, pharmacodynamics, and safety of sarpogrelate between controlled-release (CR) and immediate-release (IR) formulations after multiple-dose administration. Methods: This study was a randomized, open-label, 2-period, 2-treatment, crossover study in healthy subjects...

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Vydáno v:	Pharmacology Ročník 96; číslo 1-2; s. 68 - 75
Hlavní autoři:	Lee, Soo-Yun, Kim, Jung-Ryul, Jung, Jin Ah, Kim, Tae-Eun, Lee, Soo-Youn, Huh, Wooseong, Lee, Jae-Won, Jun, Hun, Ko, Jae-Wook
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Basel, Switzerland S. Karger AG 01.08.2015
Témata:	Adult Comparative analysis Comparative studies Controlled release technology Delayed-Action Preparations - administration & dosage Delayed-Action Preparations - pharmacokinetics Dosage and administration Dose-response relationship (Biochemistry) Drug therapy Female Health Humans Kinetics Male Original Paper Patient safety Pharmacokinetics Pharmacology Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - administration & dosage Platelet Aggregation Inhibitors - adverse effects Platelet Aggregation Inhibitors - pharmacokinetics Platelet Aggregation Inhibitors - pharmacology Serotonin agents Succinates - administration & dosage Succinates - adverse effects Succinates - pharmacokinetics Succinates - pharmacology Young Adult South Korea Multiple dose Pharmacokinetics Formulation Collagen Sarpogrelate Controlled release
ISSN:	0031-7012, 1423-0313, 1423-0313
On-line přístup:	Získat plný text
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