Inhibition of herpes simplex virus type 1 by copper oxide nanoparticles

•Copper oxide (CuO-NPs) nanoparticles significantly inhibit HSV-1 infection.•The inhibition occurs when CuO-NPs are added after virus adsorption to the cells.•100 μg/mL of CuO-NPs leads to 83.3% reduction in HSV-1 viral load. There are accumulating reports of the emergence of drug-resistant strains...

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Bibliographic Details
Published in:	Journal of virological methods Vol. 275; p. 113688
Main Authors:	Tavakoli, Ahmad, Hashemzadeh, Mohammad Sadegh
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.01.2020
Subjects:	Acyclovir - pharmacology Animals Antiviral activity antiviral agents Antiviral Agents - pharmacology Chlorocebus aethiops Copper - pharmacology Copper oxide cupric oxide cytotoxicity drug resistance drugs fluorescent antibody technique Herpes simplex virus Herpesvirus 1, Human - drug effects Human alphaherpesvirus 1 Metal Nanoparticles - chemistry Nanoparticle nanoparticles quantitative polymerase chain reaction toxicity testing Vero Cells viral antigens viral load viruses Copper oxide Nanoparticle Herpes simplex virus Antiviral activity
ISSN:	0166-0934, 1879-0984, 1879-0984
Online Access:	Get full text
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