Remineralization of Caries Lesions Extending into Dentin

Remineralization is one aspect of the overall process of tooth decay. However, it is primarily studied in shallow lesions. The aim of this study was to explore whether caries lesions in enamel and extending into the dentin can be remineralized. A single-section model was developed for the longitudin...

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Vydáno v:Journal of dental research Ročník 80; číslo 5; s. 1407 - 1411
Hlavní autor: ten Cate, J.M.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Los Angeles, CA SAGE Publications 01.05.2001
SAGE PUBLICATIONS, INC
Témata:
advanced caries
Analysis of Variance
Animals
Cariogenic Agents - metabolism
Cariostatic Agents - metabolism
Cariostatic Agents - therapeutic use
Cattle
Crystallization
Dental Caries - drug therapy
Dental Caries - metabolism
Dental Enamel - metabolism
Dental Enamel - pathology
Dental Enamel Permeability
dentin
Dentin - metabolism
Dentin - pathology
Dentin Permeability
Diphosphonates - metabolism
enamel
remineralization
Sodium Fluoride - metabolism
Sodium Fluoride - therapeutic use
Statistics, Nonparametric
Tooth Remineralization
remineralization
enamel
dentin
advanced caries
ISSN:0022-0345, 1544-0591
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Shrnutí:Remineralization is one aspect of the overall process of tooth decay. However, it is primarily studied in shallow lesions. The aim of this study was to explore whether caries lesions in enamel and extending into the dentin can be remineralized. A single-section model was developed for the longitudinal and non-destructive monitoring of changes in enamel and dentin. Lesions at least 200 μm into dentin were formed in undersaturated acetate buffers. Next, the lesions were divided into groups (three treatment and one control) and remineralized. The treatments were: weekly immersion in 1000 ppm fluoride, single treatment with methanehydroxybisphosphonate, and a constant level of 1 ppm fluoride. De- and remineralization was assessed by transverse microradiography. Remineralization was observed in enamel, but also in dentin, indicating that, deep into dentin, the pores become supersaturated to apatite formation. Treatments affected remineralization only in the outer part of enamel. Both findings are explained by a relatively fast diffusion of mineral ions, with precipitation being rate-limiting. The results suggest that dentin remineralization, underneath enamel, can be achieved and could possibly be used in clinical treatment strategies.
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ISSN:0022-0345
1544-0591
DOI:10.1177/00220345010800050401