Influence of red wine polysaccharides on cytochrome P450 enzymes and inflammatory parameters in tumor models

The soluble fraction of polysaccharides from cabernet franc red wine (SFP) previously showed antitumoral effects by modulating the immune system. The present study tested the hypothesis that the SFP can regulate CYPs in vitro in HepG2 cells and in vivo in Walker-256 tumor-bearing rats. The SFP was u...

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Vydané v:	International journal of biological macromolecules Ročník 240; s. 124385
Hlavní autori:	Stipp, Maria Carolina, Kulik, Juliana Danna, Corso, Claudia Rita, Galindo, Claudia Martins, Adami, Eliana Rezende, Evangelista, Alberto Gonçalves, Luciano, Fernando Bittencourt, Winnischofer, Sheila Maria Brochado, Cadena, Silvia Maria Suter Correia, Sassaki, Guilherme Lanzi, Acco, Alexandra
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Netherlands Elsevier B.V 15.06.2023
Predmet:	Acetylglucosaminidase Animals cancer chemoprevention cytochrome P-450 Cytochrome P-450 CYP1A1 - genetics Cytochrome P-450 CYP1A1 - metabolism Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 digestion gene expression immune system Inflammation intestines liquids liver myeloperoxidase neoplasms nuclear magnetic resonance spectroscopy polysaccharides Polysaccharides - pharmacology Rats red wines vincristine Wine INF ALT MTT MPO DMEM ANOVA FBS qPCR CYP TLR SFP D2O PBS AST IL-1 Cytochrome P450 s.c i.p Inflammation EDTA IL-6 rpm PAMP NMR TNF-α NAG Veh SEM Vin cancer GAPDH VS ELISA
ISSN:	0141-8130, 1879-0003, 1879-0003
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Abstract	The soluble fraction of polysaccharides from cabernet franc red wine (SFP) previously showed antitumoral effects by modulating the immune system. The present study tested the hypothesis that the SFP can regulate CYPs in vitro in HepG2 cells and in vivo in Walker-256 tumor-bearing rats. The SFP was used in the following protocols: (i) solid tumor, (ii) liquid tumor, and (iii) chemopreventive solid tumor. The SFP reduced solid tumor growth in both solid tumor protocols but did not inhibit liquid tumor development. The SFP reduced total CYP levels in the solid and liquid tumor protocols and reduced the gene expression of Cyp1a1 and Cyp2e1 in rats and CYP1A2 in HepG2 cells. An increase of N-acetylglucosaminidase activity was observed in all SFP-treated rats, and TNF-α levels increased in the solid tumor protocol in the vehicle, SFP, and vincristine (positive control) groups. The chemopreventive solid tumor protocol did not modify CYP levels in the liver or intestine or N-acetylglucosaminidase and myeloperoxidase activity in the liver. The in vitro digestion and nuclear magnetic resonance analyses suggested that SFP was minimally modified in the gastrointestinal system. In conclusion, SFP inhibited CYPs both in vivo and in vitro, likely as a result of its immunoinflammatory actions. [Display omitted] •The soluble fraction of polysaccharides from cabernet franc red wine (SFP) had antineoplastic effect against Walker-256 solid tumor.•SFP had antitumoral effect in treatment and chemoprentive protocols.•SFP did not inhibit liquid Walker-256 tumor development in rats.•SFP inhibited CYPs both in vivo and in vitro, likely as a result of its immunoinflammatory actions.•SFP was minimally modified in the in vitro digestion system.
AbstractList	The soluble fraction of polysaccharides from cabernet franc red wine (SFP) previously showed antitumoral effects by modulating the immune system. The present study tested the hypothesis that the SFP can regulate CYPs in vitro in HepG2 cells and in vivo in Walker-256 tumor-bearing rats. The SFP was used in the following protocols: (i) solid tumor, (ii) liquid tumor, and (iii) chemopreventive solid tumor. The SFP reduced solid tumor growth in both solid tumor protocols but did not inhibit liquid tumor development. The SFP reduced total CYP levels in the solid and liquid tumor protocols and reduced the gene expression of Cyp1a1 and Cyp2e1 in rats and CYP1A2 in HepG2 cells. An increase of N-acetylglucosaminidase activity was observed in all SFP-treated rats, and TNF-α levels increased in the solid tumor protocol in the vehicle, SFP, and vincristine (positive control) groups. The chemopreventive solid tumor protocol did not modify CYP levels in the liver or intestine or N-acetylglucosaminidase and myeloperoxidase activity in the liver. The in vitro digestion and nuclear magnetic resonance analyses suggested that SFP was minimally modified in the gastrointestinal system. In conclusion, SFP inhibited CYPs both in vivo and in vitro, likely as a result of its immunoinflammatory actions. The soluble fraction of polysaccharides from cabernet franc red wine (SFP) previously showed antitumoral effects by modulating the immune system. The present study tested the hypothesis that the SFP can regulate CYPs in vitro in HepG2 cells and in vivo in Walker-256 tumor-bearing rats. The SFP was used in the following protocols: (i) solid tumor, (ii) liquid tumor, and (iii) chemopreventive solid tumor. The SFP reduced solid tumor growth in both solid tumor protocols but did not inhibit liquid tumor development. The SFP reduced total CYP levels in the solid and liquid tumor protocols and reduced the gene expression of Cyp1a1 and Cyp2e1 in rats and CYP1A2 in HepG2 cells. An increase of N-acetylglucosaminidase activity was observed in all SFP-treated rats, and TNF-α levels increased in the solid tumor protocol in the vehicle, SFP, and vincristine (positive control) groups. The chemopreventive solid tumor protocol did not modify CYP levels in the liver or intestine or N-acetylglucosaminidase and myeloperoxidase activity in the liver. The in vitro digestion and nuclear magnetic resonance analyses suggested that SFP was minimally modified in the gastrointestinal system. In conclusion, SFP inhibited CYPs both in vivo and in vitro, likely as a result of its immunoinflammatory actions.The soluble fraction of polysaccharides from cabernet franc red wine (SFP) previously showed antitumoral effects by modulating the immune system. The present study tested the hypothesis that the SFP can regulate CYPs in vitro in HepG2 cells and in vivo in Walker-256 tumor-bearing rats. The SFP was used in the following protocols: (i) solid tumor, (ii) liquid tumor, and (iii) chemopreventive solid tumor. The SFP reduced solid tumor growth in both solid tumor protocols but did not inhibit liquid tumor development. The SFP reduced total CYP levels in the solid and liquid tumor protocols and reduced the gene expression of Cyp1a1 and Cyp2e1 in rats and CYP1A2 in HepG2 cells. An increase of N-acetylglucosaminidase activity was observed in all SFP-treated rats, and TNF-α levels increased in the solid tumor protocol in the vehicle, SFP, and vincristine (positive control) groups. The chemopreventive solid tumor protocol did not modify CYP levels in the liver or intestine or N-acetylglucosaminidase and myeloperoxidase activity in the liver. The in vitro digestion and nuclear magnetic resonance analyses suggested that SFP was minimally modified in the gastrointestinal system. In conclusion, SFP inhibited CYPs both in vivo and in vitro, likely as a result of its immunoinflammatory actions. The soluble fraction of polysaccharides from cabernet franc red wine (SFP) previously showed antitumoral effects by modulating the immune system. The present study tested the hypothesis that the SFP can regulate CYPs in vitro in HepG2 cells and in vivo in Walker-256 tumor-bearing rats. The SFP was used in the following protocols: (i) solid tumor, (ii) liquid tumor, and (iii) chemopreventive solid tumor. The SFP reduced solid tumor growth in both solid tumor protocols but did not inhibit liquid tumor development. The SFP reduced total CYP levels in the solid and liquid tumor protocols and reduced the gene expression of Cyp1a1 and Cyp2e1 in rats and CYP1A2 in HepG2 cells. An increase of N-acetylglucosaminidase activity was observed in all SFP-treated rats, and TNF-α levels increased in the solid tumor protocol in the vehicle, SFP, and vincristine (positive control) groups. The chemopreventive solid tumor protocol did not modify CYP levels in the liver or intestine or N-acetylglucosaminidase and myeloperoxidase activity in the liver. The in vitro digestion and nuclear magnetic resonance analyses suggested that SFP was minimally modified in the gastrointestinal system. In conclusion, SFP inhibited CYPs both in vivo and in vitro, likely as a result of its immunoinflammatory actions. [Display omitted] •The soluble fraction of polysaccharides from cabernet franc red wine (SFP) had antineoplastic effect against Walker-256 solid tumor.•SFP had antitumoral effect in treatment and chemoprentive protocols.•SFP did not inhibit liquid Walker-256 tumor development in rats.•SFP inhibited CYPs both in vivo and in vitro, likely as a result of its immunoinflammatory actions.•SFP was minimally modified in the in vitro digestion system.
ArticleNumber	124385
Author	Evangelista, Alberto Gonçalves Luciano, Fernando Bittencourt Corso, Claudia Rita Winnischofer, Sheila Maria Brochado Cadena, Silvia Maria Suter Correia Galindo, Claudia Martins Acco, Alexandra Stipp, Maria Carolina Adami, Eliana Rezende Kulik, Juliana Danna Sassaki, Guilherme Lanzi
Author_xml	– sequence: 1 givenname: Maria Carolina surname: Stipp fullname: Stipp, Maria Carolina organization: Department of Pharmacology, Federal University of Paraná, Curitiba, Brazil – sequence: 2 givenname: Juliana Danna surname: Kulik fullname: Kulik, Juliana Danna organization: Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, Brazil – sequence: 3 givenname: Claudia Rita surname: Corso fullname: Corso, Claudia Rita organization: Department of Pharmacology, Federal University of Paraná, Curitiba, Brazil – sequence: 4 givenname: Claudia Martins surname: Galindo fullname: Galindo, Claudia Martins organization: Department of Pharmacology, Federal University of Paraná, Curitiba, Brazil – sequence: 5 givenname: Eliana Rezende surname: Adami fullname: Adami, Eliana Rezende organization: Department of Pharmacology, Federal University of Paraná, Curitiba, Brazil – sequence: 6 givenname: Alberto Gonçalves surname: Evangelista fullname: Evangelista, Alberto Gonçalves organization: Graduate Program in Animal Science, Pontifical Catholic University of Paraná, Curitiba, Brazil – sequence: 7 givenname: Fernando Bittencourt surname: Luciano fullname: Luciano, Fernando Bittencourt organization: Graduate Program in Animal Science, Pontifical Catholic University of Paraná, Curitiba, Brazil – sequence: 8 givenname: Sheila Maria Brochado surname: Winnischofer fullname: Winnischofer, Sheila Maria Brochado organization: Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, Brazil – sequence: 9 givenname: Silvia Maria Suter Correia surname: Cadena fullname: Cadena, Silvia Maria Suter Correia organization: Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, Brazil – sequence: 10 givenname: Guilherme Lanzi surname: Sassaki fullname: Sassaki, Guilherme Lanzi organization: Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, Brazil – sequence: 11 givenname: Alexandra surname: Acco fullname: Acco, Alexandra email: aleacco@ufpr.br organization: Department of Pharmacology, Federal University of Paraná, Curitiba, Brazil
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CitedBy_id	crossref_primary_10_1016_j_ijbiomac_2025_142923 crossref_primary_10_1016_j_ijbiomac_2025_145600 crossref_primary_10_1016_j_foodchem_2024_139531
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Snippet	The soluble fraction of polysaccharides from cabernet franc red wine (SFP) previously showed antitumoral effects by modulating the immune system. The present...
SourceID	proquest pubmed crossref elsevier
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	124385
SubjectTerms	Acetylglucosaminidase Animals cancer chemoprevention cytochrome P-450 Cytochrome P-450 CYP1A1 - genetics Cytochrome P-450 CYP1A1 - metabolism Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 digestion gene expression immune system Inflammation intestines liquids liver myeloperoxidase neoplasms nuclear magnetic resonance spectroscopy polysaccharides Polysaccharides - pharmacology Rats red wines vincristine Wine
Title	Influence of red wine polysaccharides on cytochrome P450 enzymes and inflammatory parameters in tumor models
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