Systematic or Test-Guided Treatment for Tuberculosis in HIV-Infected Adults

A trial involving HIV-infected patients with CD4+ T-cell counts below 100 cells per cubic millimeter compared strategies of systematic treatment for TB and treatment only if testing revealed infection. Systematic treatment was not better than treatment guided by testing with respect to the rate of d...

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Bibliographic Details
Published in:The New England journal of medicine Vol. 382; no. 25; pp. 2397 - 2410
Main Authors: Blanc, François-Xavier, Badje, Anani D, Bonnet, Maryline, Gabillard, Delphine, Messou, Eugène, Muzoora, Conrad, Samreth, Sovannarith, Nguyen, Bang D, Borand, Laurence, Domergue, Anaïs, Rapoud, Delphine, Natukunda, Naome, Thai, Sopheak, Juchet, Sylvain, Eholié, Serge P, Lawn, Stephen D, Domoua, Serge K, Anglaret, Xavier, Laureillard, Didier
Format: Journal Article
Language:English
Published: Boston Massachusetts Medical Society 18.06.2020
Subjects:
Acquired immune deficiency syndrome
AIDS
Antiretroviral drugs
Antiretroviral therapy
Bacteria
Bacterial infections
CD4 antigen
Death
Drug dosages
Drug resistance
Drug therapy
Ethambutol
HIV
Human immunodeficiency virus
Infections
Isoniazid
Life Sciences
Lymphocytes T
Mortality
Pyrazinamide
Radiography
Rifampin
Tuberculosis
Uganda
Vietnam
Ivory Coast
Cambodia
ISSN:0028-4793, 1533-4406, 1533-4406
Online Access:Get full text
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Summary:A trial involving HIV-infected patients with CD4+ T-cell counts below 100 cells per cubic millimeter compared strategies of systematic treatment for TB and treatment only if testing revealed infection. Systematic treatment was not better than treatment guided by testing with respect to the rate of death or bacterial infection.
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa1910708