Study of the polyacrylate interpenetration in a collagen-polyurethane matrix to prepare novel hydrogels for biomedical applications

Currently, the control of the properties of collagen based hydrogels represents a promising area of research to develop novel materials for biomedical applications. The crosslinking of the collagen with trifunctional polyurethane (PU) allows a hybrid matrix to be formed by improving the coupling wit...

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Veröffentlicht in:International journal of biological macromolecules Jg. 156; S. 27 - 39
Hauptverfasser: Claudio-Rizo, Jesús A., González-Lara, Irving A., Flores-Guía, Tirso E., Cano-Salazar, Lucía F., Cabrera-Munguía, Denis A., Becerra-Rodríguez, Juan J.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Netherlands Elsevier B.V 01.08.2020
Schlagworte:
Acrylates - chemistry
Animals
Bandages
biocompatibility
biocompatible materials
Collagen
Collagen - chemistry
Collagen - pharmacology
Cross-Linking Reagents - chemistry
crosslinking
Escherichia coli
Escherichia coli - drug effects
fibroblasts
Fibroblasts - drug effects
Humans
Hydrogel
hydrogels
Hydrogels - analysis
Hydrogels - chemistry
Materials Testing
metabolism
Microscopy, Electron, Scanning
monocytes
Monocytes - drug effects
Polyacrylate
polyacrylic acid
Polymerization
Polyurethane
polyurethanes
Polyurethanes - chemistry
proteolysis
Scattering, Radiation
Semi-interpenetrated networks
Spectroscopy, Fourier Transform Infrared
Swine
thermal stability
Thermography
tissue repair
Water - chemistry
Water - metabolism
Wound dressing
Wound dressing
Hydrogel
Polyacrylate
Collagen
Polyurethane
Semi-interpenetrated networks
ISSN:0141-8130, 1879-0003, 1879-0003
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Zusammenfassung:Currently, the control of the properties of collagen based hydrogels represents a promising area of research to develop novel materials for biomedical applications. The crosslinking of the collagen with trifunctional polyurethane (PU) allows a hybrid matrix to be formed by improving the coupling with exogenous polymeric chains to generate innovative semi-interpenetrated network (semi-IPN) hydrogels. The incorporation of polyacrylate (PA) within a hybrid matrix of collagen-PU allows to regulate the structure and physicochemical properties such as polymerization rate, physicochemical crosslinking, thermal stability, storage module and swelling/degradation behavior of the 3D matrices in the hydrogel state, also exhibiting modulation of their in vitro biocompatibility properties. This work contemplates the study of the effect of PA concentration on the physicochemical properties and the in vitro biological response of these novel semi-IPN hydrogels based on collagen-PU-PA. The results indicate that semi-IPN hydrogels that include 20 wt% of PA exhibit improved swelling with respect to the collagen-PU hydrogel, controlling the degradation rate in acidic, alkaline and proteolytic media; showing E. coli inhibition capacity, high hemocompatibility and not altering the metabolism of monocytes and fibroblasts growing on them. Therefore, these novel hydrogels represent biomaterials with potential application in biomedical strategies such as wound healing dressings. [Display omitted] •The polyacrylate content regulates the polymerization rate, structure andphysicochemical properties of hydrogels.•A direct relationship among the polyacrylate concentration and mechanical, thermal improvement and degradation control is observed.•The presence of polyacrylate grants improved antibacterial capacity and hemocompatibility.•The biocompatibility of collagen is not altered in hydrogels that include 20 wt. % of polyacrylate.•These hydrogels represent biomaterials for potential application as chronic wound healing dressings.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0141-8130
1879-0003
1879-0003
DOI:10.1016/j.ijbiomac.2020.04.005