Exposure to metals during pregnancy and neuropsychological development at the age of 4 years
There is insufficient epidemiological evidence for deciding whether prenatal exposure to the current low-levels of metals in developed countries may affect neuropsychological function in early childhood. Our goal was to evaluate potential neurotoxic effects of prenatal exposure to seven metals (coba...
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| Vydané v: | Neurotoxicology (Park Forest South) Ročník 40; s. 16 - 22 |
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| Hlavní autori: | , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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Amsterdam
Elsevier
01.01.2014
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| ISSN: | 0161-813X, 1872-9711, 1872-9711 |
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| Abstract | There is insufficient epidemiological evidence for deciding whether prenatal exposure to the current low-levels of metals in developed countries may affect neuropsychological function in early childhood.
Our goal was to evaluate potential neurotoxic effects of prenatal exposure to seven metals (cobalt, copper, arsenic, cadmium, antimony, thallium and lead), during the 1st and 3rd trimester of pregnancy, on child neuropsychological development at 4 years of age.
This study was based on a population-based birth cohort established in Sabadell (Catalonia, Spain) as part of the INMA [Environment and Childhood] Project. Metals were measured in 485 urine samples collected from mothers during the 1st and 3rd trimester of pregnancy. We assessed the neuropsychological development of 553 4-year-olds with the McCarthy Scales of Childrens' Abilitites (MSCA), together with their ADHD symptomatology, using the ADHD-DSM-IV criteria. A total of 385 children were included in the present study.
We found no statistically significant associations between metals and general cognitive scale or executive function of the MSCA. We found negative coefficients for the exposure to cadmium 1st trimester, cadmium 3rd trimester and lead 3rd trimester on the general cognitive score of MSCA, although these results were not significant. We did not find any association between prenatal exposure to metals and ADHD symptomatology at the age of 4 years.
Our results do not suggest that prenatal exposure to current low-levels of metals impairs children's cognitive development during preschool years. |
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| AbstractList | There is insufficient epidemiological evidence for deciding whether prenatal exposure to the current low-levels of metals in developed countries may affect neuropsychological function in early childhood.BACKGROUNDThere is insufficient epidemiological evidence for deciding whether prenatal exposure to the current low-levels of metals in developed countries may affect neuropsychological function in early childhood.Our goal was to evaluate potential neurotoxic effects of prenatal exposure to seven metals (cobalt, copper, arsenic, cadmium, antimony, thallium and lead), during the 1st and 3rd trimester of pregnancy, on child neuropsychological development at 4 years of age.OBJECTIVESOur goal was to evaluate potential neurotoxic effects of prenatal exposure to seven metals (cobalt, copper, arsenic, cadmium, antimony, thallium and lead), during the 1st and 3rd trimester of pregnancy, on child neuropsychological development at 4 years of age.This study was based on a population-based birth cohort established in Sabadell (Catalonia, Spain) as part of the INMA [Environment and Childhood] Project. Metals were measured in 485 urine samples collected from mothers during the 1st and 3rd trimester of pregnancy. We assessed the neuropsychological development of 553 4-year-olds with the McCarthy Scales of Childrens' Abilitites (MSCA), together with their ADHD symptomatology, using the ADHD-DSM-IV criteria. A total of 385 children were included in the present study.MATERIALS AND METHODSThis study was based on a population-based birth cohort established in Sabadell (Catalonia, Spain) as part of the INMA [Environment and Childhood] Project. Metals were measured in 485 urine samples collected from mothers during the 1st and 3rd trimester of pregnancy. We assessed the neuropsychological development of 553 4-year-olds with the McCarthy Scales of Childrens' Abilitites (MSCA), together with their ADHD symptomatology, using the ADHD-DSM-IV criteria. A total of 385 children were included in the present study.We found no statistically significant associations between metals and general cognitive scale or executive function of the MSCA. We found negative coefficients for the exposure to cadmium 1st trimester, cadmium 3rd trimester and lead 3rd trimester on the general cognitive score of MSCA, although these results were not significant. We did not find any association between prenatal exposure to metals and ADHD symptomatology at the age of 4 years.RESULTSWe found no statistically significant associations between metals and general cognitive scale or executive function of the MSCA. We found negative coefficients for the exposure to cadmium 1st trimester, cadmium 3rd trimester and lead 3rd trimester on the general cognitive score of MSCA, although these results were not significant. We did not find any association between prenatal exposure to metals and ADHD symptomatology at the age of 4 years.Our results do not suggest that prenatal exposure to current low-levels of metals impairs children's cognitive development during preschool years.CONCLUSIONSOur results do not suggest that prenatal exposure to current low-levels of metals impairs children's cognitive development during preschool years. There is insufficient epidemiological evidence for deciding whether prenatal exposure to the current low-levels of metals in developed countries may affect neuropsychological function in early childhood. Our goal was to evaluate potential neurotoxic effects of prenatal exposure to seven metals (cobalt, copper, arsenic, cadmium, antimony, thallium and lead), during the 1st and 3rd trimester of pregnancy, on child neuropsychological development at 4 years of age. This study was based on a population-based birth cohort established in Sabadell (Catalonia, Spain) as part of the INMA [Environment and Childhood] Project. Metals were measured in 485 urine samples collected from mothers during the 1st and 3rd trimester of pregnancy. We assessed the neuropsychological development of 553 4-year-olds with the McCarthy Scales of Childrens' Abilitites (MSCA), together with their ADHD symptomatology, using the ADHD-DSM-IV criteria. A total of 385 children were included in the present study. We found no statistically significant associations between metals and general cognitive scale or executive function of the MSCA. We found negative coefficients for the exposure to cadmium 1st trimester, cadmium 3rd trimester and lead 3rd trimester on the general cognitive score of MSCA, although these results were not significant. We did not find any association between prenatal exposure to metals and ADHD symptomatology at the age of 4 years. Our results do not suggest that prenatal exposure to current low-levels of metals impairs children's cognitive development during preschool years. |
| Author | Cáceres, Alejandro Sunyer, Jordi Guxens, Mònica Fort, Marta Forns, Joan Gascon, Mireia Casas, Maribel Grimalt, Joan O. Garcia-Esteban, Raquel Julvez, Jordi |
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| Keywords | Human Environmental exposure Toxicity Nervous system Cognition Exposure Heavy metals Heavy metal Pregnancy Progeny Health and environment Child development Environment Female Cognitive development Neuropsychology Woman Child Neuropsychologia Public health ADHD HI SCL-90-R Q-ICP-MS Revised Symptom Checklist limits of detection Coef Weschler Adult Intelligence-Third Edition environment and childhood project IA INMA 95% CI LOD MSCA attention deficit and hyperactivity disorder WAIS-III McCarthy Scales of Children's Abilities inductively coupled plasma quadruple mass spectrometry hyperactivity/impulsivity scale ADHD-DSM-IV 95% confidence interval coefficient ADHD Criteria of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition form inattention scale |
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| SubjectTerms | Air. Soil. Water. Waste. Feeding Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Child Development - drug effects Child, Preschool Environment. Living conditions Female General aspects Humans Male Medical sciences Metals - toxicity Metals - urine Metals and various inorganic compounds Miscellaneous Neuropsychological Tests Pregnancy Prenatal Exposure Delayed Effects - chemically induced Public health. Hygiene Public health. Hygiene-occupational medicine Toxicology |
| Title | Exposure to metals during pregnancy and neuropsychological development at the age of 4 years |
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