Intradermal versus subcutaneous immunization: Effects of administration route using a lipid-PLGA hybrid nanoparticle tuberculosis vaccine

Tuberculosis (TB) remains a significant global health challenge, latently affecting around a quarter of the global population. The sole licensed TB vaccine, Mycobacterium bovis Bacillus Calmette-Guérin (BCG), shows variable efficacy, particularly among adolescents and adults, underscoring the pressi...

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Bibliographic Details
Published in:	European journal of pharmaceutical sciences Vol. 205; p. 106995
Main Authors:	Szachniewicz, M.M., van den Eeden, S.J.F., van Meijgaarden, K.E., Franken, K.L.M.C., van Veen, S., Geluk, A., Bouwstra, J.A., Ottenhoff, T.H.M.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.02.2025
Subjects:	Adjuvant Animals Antigens, Bacterial - administration & dosage Antigens, Bacterial - immunology Bacillus Calmette-Guérin Bacterial Proteins - administration & dosage Bacterial Proteins - immunology Cationic lipid−PLGA hybrid nanoparticles Female Immunogenicity Injections, Intradermal Injections, Subcutaneous Lipids - chemistry Mice Mice, Inbred C57BL Nanoparticles - administration & dosage Nanoparticles - chemistry Polylactic Acid-Polyglycolic Acid Copolymer - administration & dosage Polylactic Acid-Polyglycolic Acid Copolymer - chemistry Subunit vaccine Tuberculosis Tuberculosis - immunology Tuberculosis - prevention & control Tuberculosis Vaccines - administration & dosage Tuberculosis Vaccines - chemistry Tuberculosis Vaccines - immunology Vaccine delivery system NP Ag HRP MHC CpG ODN TNF Cationic lipid−PLGA hybrid nanoparticles IFN PDI Subunit vaccine FDR FBS pH Adjuvant TLR DOPC i.d KLRG1 DOPE Th1/Th2 UMAP CD DOBAQ BCG MDR-TB s.c IQR AER rpm TB Bacillus Calmette-Guérin Tuberculosis CCR PLGA Immunogenicity APC PE EPC Mtb CXCR Vaccine delivery system HLA LUMC MPLA PD-1 Ig PCR DC
ISSN:	0928-0987, 1879-0720, 1879-0720
Online Access:	Get full text
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