Accuracy Analysis of Hybrid Stochastic Simulation Algorithm on Linear Chain Reaction Systems

Noise in cellular systems is often modeled and simulated with Gillespie’s stochastic simulation algorithm (SSA), but the low efficiency of the SSA limits its application to large biochemical networks. To improve the efficiency of stochastic simulations, Haseltine and Rawlings (HR) proposed a hybrid...

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Bibliographic Details
Published in:	Bulletin of mathematical biology Vol. 81; no. 8; pp. 3024 - 3052
Main Authors:	Chen, Minghan, Wang, Shuo, Cao, Yang
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.08.2019 Springer Nature B.V
Subjects:	Algorithms Cell Biology Chains Computer simulation Differential equations Life Sciences Mathematical and Computational Biology Mathematical models Mathematics Mathematics and Statistics Model accuracy Molecular chains Ordinary differential equations Organic chemistry Special Issue: Gillespie and His Algorithms Stochastic models SSA Accuracy analysis Next slow reaction firing time Linear chain reaction systems Hybrid stochastic algorithm
ISSN:	0092-8240, 1522-9602, 1522-9602
Online Access:	Get full text
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