Interpreting non-linear drug diffusion data: Utilizing Korsmeyer-Peppas model to study drug release from liposomes

The aim of this work was to clarify the dynamics behind the influence of ionic strength on the changes in drug release from large unilamellar vesicles (LUVs). For this purpose, we have investigated the transport of two different model drugs (caffeine and hydrocortisone) formulated into liposomes thr...

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Bibliographic Details
Published in:	European journal of pharmaceutical sciences Vol. 138; p. 105026
Main Authors:	Wu, Iren Yeeling, Bala, Sonali, Škalko-Basnet, Nataša, di Cagno, Massimiliano Pio
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.10.2019
Subjects:	Cholesterol Cholesterol - metabolism Diffusion Drug Delivery Systems - methods Drug Liberation - physiology Drug release kinetics Kinetics Korsmeyer-Peppas model Large unilamellar vesicles Liposomes - chemistry Membranes - metabolism Osmotic stress Permepad Pharmaceutical Preparations - metabolism RT iso LUVs SPC K Osmotic stress SD R2adj Large unilamellar vesicles Korsmeyer-Peppas model hyper EE PBS hypo Mt/M Cholesterol n RB Drug release kinetics t Permepad ZP PI RL PL
ISSN:	0928-0987, 1879-0720, 1879-0720
Online Access:	Get full text
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