Understanding the regulation of chronic wounds by tissue inhibitors of matrix metalloproteinases through mathematical modelling

Understanding the biochemistry and pharmacodynamics of chronic wounds is of key importance, due to the millions of people in the UK affected and the significant cost to the NHS. Chronic wounds are characterised by elevated concentrations of matrix metalloproteinases (MMPs) that destroy the surroundi...

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Bibliographic Details

Published in:	Journal of theoretical biology Vol. 604; p. 112083
Main Authors:	Dari, Sonia, O’dea, Reuben D., Fadai, Nabil T.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 07.05.2025
Subjects:	Chronic Disease Extracellular Matrix - metabolism Fibroblasts - metabolism Humans Matrix Metalloproteinases - metabolism Models, Biological Tissue Inhibitor of Metalloproteinases - metabolism Wound Healing - physiology
ISSN:	0022-5193, 1095-8541, 1095-8541
Online Access:	Get full text
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