Quantification of Ivacaftor, Tezacaftor, Elexacaftor, and Lumacaftor and their active metabolites in plasma using UHPLC-MS/MS: Doors open to the application of therapeutic drug monitoring in cystic fibrosis treatment

An ultra-high performance liquid chromatography-tandem mass spectrometry method was developed to quantify the cystic fibrosis transmembrane conductance regulator (CFTR) modulators ivacaftor, tezacaftor, elexacaftor, and lumacaftor and their active metabolites hydroxymethyl ivacaftor, tezacaftor M1,...

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Bibliographic Details
Published in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Vol. 1258; p. 124604
Main Authors:	Wessels, A. Mireille A., Elzinga, Femke A., Koppelman, Gerard H., Akkerman, Onno W., Mian, Paola, Touw, Daan J.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 15.05.2025
Subjects:	ambient temperature Aminophenols - blood Aminophenols - chemistry Aminophenols - metabolism Aminophenols - pharmacokinetics Aminophenols - therapeutic use Aminopyridines - blood Aminopyridines - chemistry Aminopyridines - metabolism Aminopyridines - pharmacokinetics Aminopyridines - therapeutic use Benzodioxoles - blood Benzodioxoles - chemistry Benzodioxoles - metabolism Benzodioxoles - pharmacokinetics Benzodioxoles - therapeutic use blood serum Chromatography, High Pressure Liquid - methods Cystic fibrosis Cystic Fibrosis - blood Cystic Fibrosis - drug therapy Cystic Fibrosis Transmembrane Conductance Regulator Drug Combinations Drug Monitoring - methods drugs Elexacaftor Food and Drug Administration freeze-thaw cycles heparin Humans Indoles - blood Indoles - chemistry Indoles - metabolism Indoles - therapeutic use industry isotope dilution technique isotope labeling Ivacaftor Limit of Detection Linear Models liquid chromatography Lumacaftor metabolites Phenylpropionates - blood Phenylpropionates - therapeutic use Pyrazoles - blood Pyrazoles - chemistry Pyrazoles - metabolism Pyrazoles - therapeutic use Pyridines Pyrrolidines Quinolones - blood Quinolones - chemistry Quinolones - metabolism Quinolones - pharmacokinetics Quinolones - therapeutic use refrigerators Reproducibility of Results spectrometers stable isotopes tandem mass spectrometry Tandem Mass Spectrometry - methods Tezacaftor therapeutics UHPLC-MS/MS LLOQ Ivacaftor FDA CF ELEXA-M23 TEZA-M1 ELEXA Cystic fibrosis Elexacaftor UHPLC-MS IS Lumacaftor PwCF QC CV UHPLC-MS/MS IVA IVA-M1 EMA PK Tezacaftor CFTR LUMA TEZA
ISSN:	1570-0232, 1873-376X, 1873-376X
Online Access:	Get full text
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