Bimolecular complementation affinity purification (BiCAP) reveals dimer-specific protein interactions for ERBB2 dimers

The dynamic assembly of multiprotein complexes is a central mechanism of many cell signaling pathways. This process is key to maintaining the spatiotemporal specificity required for an accurate, yet adaptive, response to rapidly changing cellular conditions. We describe a technique for the specific...

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Bibliographic Details

Published in:	Science signaling Vol. 9; no. 436; p. ra69
Main Authors:	Croucher, David R, Iconomou, Mary, Hastings, Jordan F, Kennedy, Sean P, Han, Jeremy Z R, Shearer, Robert F, McKenna, Jessie, Wan, Adrian, Lau, Joseph, Aparicio, Samuel, Saunders, Darren N
Format:	Journal Article
Language:	English
Published:	United States 12.07.2016
Subjects:	Breast Neoplasms - metabolism Breast Neoplasms - pathology Female HEK293 Cells Humans MAP Kinase Signaling System MCF-7 Cells Protein Multimerization Receptor, Epidermal Growth Factor - isolation & purification Receptor, Epidermal Growth Factor - metabolism Receptor, ErbB-2 - isolation & purification Receptor, ErbB-2 - metabolism Receptor, ErbB-3 - isolation & purification Receptor, ErbB-3 - metabolism
ISSN:	1937-9145, 1937-9145
Online Access:	Get more information
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