Intestinal Blastocystis is linked to healthier diets and more favorable cardiometabolic outcomes in 56,989 individuals from 32 countries

Diet impacts human health, influencing body adiposity and the risk of developing cardiometabolic diseases. The gut microbiome is a key player in the diet-health axis, but while its bacterial fraction is widely studied, the role of micro-eukaryotes, including Blastocystis, is underexplored. We perfor...

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Vydané v:	Cell Ročník 187; číslo 17; s. 4554
Hlavní autori:	Piperni, Elisa, Nguyen, Long H, Manghi, Paolo, Kim, Hanseul, Pasolli, Edoardo, Andreu-Sánchez, Sergio, Arrè, Alberto, Bermingham, Kate M, Blanco-Míguez, Aitor, Manara, Serena, Valles-Colomer, Mireia, Bakker, Elco, Busonero, Fabio, Davies, Richard, Fiorillo, Edoardo, Giordano, Francesca, Hadjigeorgiou, George, Leeming, Emily R, Lobina, Monia, Masala, Marco, Maschio, Andrea, McIver, Lauren J, Pala, Mauro, Pitzalis, Maristella, Wolf, Jonathan, Fu, Jingyuan, Zhernakova, Alexandra, Cacciò, Simone M, Cucca, Francesco, Berry, Sarah E, Ercolini, Danilo, Chan, Andrew T, Huttenhower, Curtis, Spector, Tim D, Segata, Nicola, Asnicar, Francesco
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 22.08.2024
Predmet:	Adult Blastocystis - metabolism Blastocystis Infections Cardiovascular Diseases - prevention & control Diet Female Gastrointestinal Microbiome Humans Intestines - microbiology Intestines - parasitology Male Metagenome Middle Aged Obesity diet and microbiome integrative metagenomics metagenomics microbiome meta-analysis transkingdom microbiome analysis cardiometabolic health micro-eukaryote Blastocystis hominis human gut microbiome
ISSN:	1097-4172, 1097-4172
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Abstract	Diet impacts human health, influencing body adiposity and the risk of developing cardiometabolic diseases. The gut microbiome is a key player in the diet-health axis, but while its bacterial fraction is widely studied, the role of micro-eukaryotes, including Blastocystis, is underexplored. We performed a global-scale analysis on 56,989 metagenomes and showed that human Blastocystis exhibits distinct prevalence patterns linked to geography, lifestyle, and dietary habits. Blastocystis presence defined a specific bacterial signature and was positively associated with more favorable cardiometabolic profiles and negatively with obesity (p < 1e-16) and disorders linked to altered gut ecology (p < 1e-8). In a diet intervention study involving 1,124 individuals, improvements in dietary quality were linked to weight loss and increases in Blastocystis prevalence (p = 0.003) and abundance (p < 1e-7). Our findings suggest a potentially beneficial role for Blastocystis, which may help explain personalized host responses to diet and downstream disease etiopathogenesis.
AbstractList	Diet impacts human health, influencing body adiposity and the risk of developing cardiometabolic diseases. The gut microbiome is a key player in the diet-health axis, but while its bacterial fraction is widely studied, the role of micro-eukaryotes, including Blastocystis, is underexplored. We performed a global-scale analysis on 56,989 metagenomes and showed that human Blastocystis exhibits distinct prevalence patterns linked to geography, lifestyle, and dietary habits. Blastocystis presence defined a specific bacterial signature and was positively associated with more favorable cardiometabolic profiles and negatively with obesity (p < 1e-16) and disorders linked to altered gut ecology (p < 1e-8). In a diet intervention study involving 1,124 individuals, improvements in dietary quality were linked to weight loss and increases in Blastocystis prevalence (p = 0.003) and abundance (p < 1e-7). Our findings suggest a potentially beneficial role for Blastocystis, which may help explain personalized host responses to diet and downstream disease etiopathogenesis. Diet impacts human health, influencing body adiposity and the risk of developing cardiometabolic diseases. The gut microbiome is a key player in the diet-health axis, but while its bacterial fraction is widely studied, the role of micro-eukaryotes, including Blastocystis, is underexplored. We performed a global-scale analysis on 56,989 metagenomes and showed that human Blastocystis exhibits distinct prevalence patterns linked to geography, lifestyle, and dietary habits. Blastocystis presence defined a specific bacterial signature and was positively associated with more favorable cardiometabolic profiles and negatively with obesity (p < 1e-16) and disorders linked to altered gut ecology (p < 1e-8). In a diet intervention study involving 1,124 individuals, improvements in dietary quality were linked to weight loss and increases in Blastocystis prevalence (p = 0.003) and abundance (p < 1e-7). Our findings suggest a potentially beneficial role for Blastocystis, which may help explain personalized host responses to diet and downstream disease etiopathogenesis.Diet impacts human health, influencing body adiposity and the risk of developing cardiometabolic diseases. The gut microbiome is a key player in the diet-health axis, but while its bacterial fraction is widely studied, the role of micro-eukaryotes, including Blastocystis, is underexplored. We performed a global-scale analysis on 56,989 metagenomes and showed that human Blastocystis exhibits distinct prevalence patterns linked to geography, lifestyle, and dietary habits. Blastocystis presence defined a specific bacterial signature and was positively associated with more favorable cardiometabolic profiles and negatively with obesity (p < 1e-16) and disorders linked to altered gut ecology (p < 1e-8). In a diet intervention study involving 1,124 individuals, improvements in dietary quality were linked to weight loss and increases in Blastocystis prevalence (p = 0.003) and abundance (p < 1e-7). Our findings suggest a potentially beneficial role for Blastocystis, which may help explain personalized host responses to diet and downstream disease etiopathogenesis.
Author	Arrè, Alberto McIver, Lauren J Leeming, Emily R Cucca, Francesco Bakker, Elco Pitzalis, Maristella Wolf, Jonathan Ercolini, Danilo Kim, Hanseul Cacciò, Simone M Valles-Colomer, Mireia Masala, Marco Pala, Mauro Asnicar, Francesco Blanco-Míguez, Aitor Segata, Nicola Andreu-Sánchez, Sergio Busonero, Fabio Huttenhower, Curtis Maschio, Andrea Chan, Andrew T Fu, Jingyuan Davies, Richard Lobina, Monia Pasolli, Edoardo Manghi, Paolo Giordano, Francesca Nguyen, Long H Hadjigeorgiou, George Spector, Tim D Berry, Sarah E Fiorillo, Edoardo Bermingham, Kate M Zhernakova, Alexandra Piperni, Elisa Manara, Serena
Author_xml	– sequence: 1 givenname: Elisa surname: Piperni fullname: Piperni, Elisa organization: Department CIBIO, University of Trento, Trento, Italy; IEO, Istituto Europeo di Oncologia IRCSS, Milan, Italy – sequence: 2 givenname: Long H surname: Nguyen fullname: Nguyen, Long H organization: Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA; Harvard Chan Microbiome in Public Health Center, Boston, MA, USA – sequence: 3 givenname: Paolo surname: Manghi fullname: Manghi, Paolo organization: Department CIBIO, University of Trento, Trento, Italy – sequence: 4 givenname: Hanseul surname: Kim fullname: Kim, Hanseul organization: Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA – sequence: 5 givenname: Edoardo surname: Pasolli fullname: Pasolli, Edoardo organization: Department of Agricultural Sciences, University of Naples Federico II, Portici, Italy – sequence: 6 givenname: Sergio surname: Andreu-Sánchez fullname: Andreu-Sánchez, Sergio organization: Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands – sequence: 7 givenname: Alberto surname: Arrè fullname: Arrè, Alberto organization: Department CIBIO, University of Trento, Trento, Italy; Zoe Ltd, London, UK – sequence: 8 givenname: Kate M surname: Bermingham fullname: Bermingham, Kate M organization: Zoe Ltd, London, UK; Department of Nutritional Sciences, King's College London, London, UK – sequence: 9 givenname: Aitor surname: Blanco-Míguez fullname: Blanco-Míguez, Aitor organization: Department CIBIO, University of Trento, Trento, Italy – sequence: 10 givenname: Serena surname: Manara fullname: Manara, Serena organization: Department CIBIO, University of Trento, Trento, Italy – sequence: 11 givenname: Mireia surname: Valles-Colomer fullname: Valles-Colomer, Mireia organization: Department CIBIO, University of Trento, Trento, Italy – sequence: 12 givenname: Elco surname: Bakker fullname: Bakker, Elco organization: Zoe Ltd, London, UK – sequence: 13 givenname: Fabio surname: Busonero fullname: Busonero, Fabio organization: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Cagliari, Italy – sequence: 14 givenname: Richard surname: Davies fullname: Davies, Richard organization: Zoe Ltd, London, UK – sequence: 15 givenname: Edoardo surname: Fiorillo fullname: Fiorillo, Edoardo organization: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Cagliari, Italy – sequence: 16 givenname: Francesca surname: Giordano fullname: Giordano, Francesca organization: Zoe Ltd, London, UK – sequence: 17 givenname: George surname: Hadjigeorgiou fullname: Hadjigeorgiou, George organization: Zoe Ltd, London, UK – sequence: 18 givenname: Emily R surname: Leeming fullname: Leeming, Emily R organization: Department of Twins Research and Genetic Epidemiology, King's College London, London, UK – sequence: 19 givenname: Monia surname: Lobina fullname: Lobina, Monia organization: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Cagliari, Italy – sequence: 20 givenname: Marco surname: Masala fullname: Masala, Marco organization: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Cagliari, Italy – sequence: 21 givenname: Andrea surname: Maschio fullname: Maschio, Andrea organization: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Cagliari, Italy – sequence: 22 givenname: Lauren J surname: McIver fullname: McIver, Lauren J organization: Harvard T.H. Chan School of Public Health, Boston, MA, USA – sequence: 23 givenname: Mauro surname: Pala fullname: Pala, Mauro organization: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Cagliari, Italy – sequence: 24 givenname: Maristella surname: Pitzalis fullname: Pitzalis, Maristella organization: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Cagliari, Italy – sequence: 25 givenname: Jonathan surname: Wolf fullname: Wolf, Jonathan organization: Zoe Ltd, London, UK – sequence: 26 givenname: Jingyuan surname: Fu fullname: Fu, Jingyuan organization: Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands – sequence: 27 givenname: Alexandra surname: Zhernakova fullname: Zhernakova, Alexandra organization: Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands – sequence: 28 givenname: Simone M surname: Cacciò fullname: Cacciò, Simone M organization: Department of Infectious Diseases, Istituto Superiore Di Sanità, Rome, Italy – sequence: 29 givenname: Francesco surname: Cucca fullname: Cucca, Francesco organization: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Cagliari, Italy; Dipartimento di Scienze Biomediche, Università degli Studi di Sassari, Sassari, Italy – sequence: 30 givenname: Sarah E surname: Berry fullname: Berry, Sarah E organization: Department of Nutritional Sciences, King's College London, London, UK – sequence: 31 givenname: Danilo surname: Ercolini fullname: Ercolini, Danilo organization: Department of Agricultural Sciences, University of Naples Federico II, Portici, Italy – sequence: 32 givenname: Andrew T surname: Chan fullname: Chan, Andrew T organization: Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA; Harvard Chan Microbiome in Public Health Center, Boston, MA, USA – sequence: 33 givenname: Curtis surname: Huttenhower fullname: Huttenhower, Curtis organization: Harvard T.H. Chan School of Public Health, Boston, MA, USA; The Broad Institute of MIT and Harvard, Cambridge, MA, USA – sequence: 34 givenname: Tim D surname: Spector fullname: Spector, Tim D organization: Department of Twins Research and Genetic Epidemiology, King's College London, London, UK – sequence: 35 givenname: Nicola surname: Segata fullname: Segata, Nicola email: nicola.segata@unitn.it organization: Department CIBIO, University of Trento, Trento, Italy; IEO, Istituto Europeo di Oncologia IRCSS, Milan, Italy; Department of Twins Research and Genetic Epidemiology, King's College London, London, UK. Electronic address: nicola.segata@unitn.it – sequence: 36 givenname: Francesco surname: Asnicar fullname: Asnicar, Francesco email: f.asnicar@unitn.it organization: Department CIBIO, University of Trento, Trento, Italy. Electronic address: f.asnicar@unitn.it
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Keywords	diet and microbiome integrative metagenomics metagenomics microbiome meta-analysis transkingdom microbiome analysis cardiometabolic health micro-eukaryote Blastocystis hominis human gut microbiome
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SubjectTerms	Adult Blastocystis - metabolism Blastocystis Infections Cardiovascular Diseases - prevention & control Diet Female Gastrointestinal Microbiome Humans Intestines - microbiology Intestines - parasitology Male Metagenome Middle Aged Obesity
Title	Intestinal Blastocystis is linked to healthier diets and more favorable cardiometabolic outcomes in 56,989 individuals from 32 countries
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