Structural characterization and anticancer properties of a novel mushroom-derived rhamnogalactan in a triple-negative breast cancer model
Mushroom-derived polysaccharides are known for their diverse biological activities, including immunomodulatory and anticancer properties. Breast cancer, the leading cause of cancer-related death among women worldwide, lacks targeted molecular therapies, underscoring the need for novel therapeutic ag...
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| Vydáno v: | Carbohydrate polymers Ročník 364; s. 123735 |
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| Hlavní autoři: | , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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England
Elsevier Ltd
15.09.2025
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| ISSN: | 0144-8617, 1879-1344, 1879-1344 |
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| Abstract | Mushroom-derived polysaccharides are known for their diverse biological activities, including immunomodulatory and anticancer properties. Breast cancer, the leading cause of cancer-related death among women worldwide, lacks targeted molecular therapies, underscoring the need for novel therapeutic agents. In this study, we extracted, purified, and characterized a novel heteropolysaccharide (HTP) - a rhamnogalactan - composed of galactose (72.6 %) and rhamnose (27.4 %) from the edible mushroom Lactarius quieticolor. Structural analysis revealed that HTP consists of a (1 → 6)-linked α-d-galactopyranose backbone, heavily substituted at O-2 by non-reducing rhamnose units, with a weight-average molar mass of 2.41 × 104 g.mol−1. In vitro assays using a triple-negative breast cancer (TNBC) cell model - the most aggressive subtype - showed a significant reduction in cell viability (50 % at 1200 μg·mL−1). Furthermore, an additive effect was observed when co-administered with the chemotherapy drug paclitaxel, reducing the cell viability to 42 %. These findings suggest potential therapeutic applications of the purified mushroom rhamnogalactan reported in this study against TNBC.
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| AbstractList | Mushroom-derived polysaccharides are known for their diverse biological activities, including immunomodulatory and anticancer properties. Breast cancer, the leading cause of cancer-related death among women worldwide, lacks targeted molecular therapies, underscoring the need for novel therapeutic agents. In this study, we extracted, purified, and characterized a novel heteropolysaccharide (HTP) - a rhamnogalactan - composed of galactose (72.6 %) and rhamnose (27.4 %) from the edible mushroom Lactarius quieticolor. Structural analysis revealed that HTP consists of a (1 → 6)-linked α-d-galactopyranose backbone, heavily substituted at O-2 by non-reducing rhamnose units, with a weight-average molar mass of 2.41 × 10⁴ g.mol⁻¹. In vitro assays using a triple-negative breast cancer (TNBC) cell model - the most aggressive subtype - showed a significant reduction in cell viability (50 % at 1200 μg·mL⁻¹). Furthermore, an additive effect was observed when co-administered with the chemotherapy drug paclitaxel, reducing the cell viability to 42 %. These findings suggest potential therapeutic applications of the purified mushroom rhamnogalactan reported in this study against TNBC. Mushroom-derived polysaccharides are known for their diverse biological activities, including immunomodulatory and anticancer properties. Breast cancer, the leading cause of cancer-related death among women worldwide, lacks targeted molecular therapies, underscoring the need for novel therapeutic agents. In this study, we extracted, purified, and characterized a novel heteropolysaccharide (HTP) - a rhamnogalactan - composed of galactose (72.6 %) and rhamnose (27.4 %) from the edible mushroom Lactarius quieticolor. Structural analysis revealed that HTP consists of a (1 → 6)-linked α-d-galactopyranose backbone, heavily substituted at O-2 by non-reducing rhamnose units, with a weight-average molar mass of 2.41 × 104 g.mol−1. In vitro assays using a triple-negative breast cancer (TNBC) cell model - the most aggressive subtype - showed a significant reduction in cell viability (50 % at 1200 μg·mL−1). Furthermore, an additive effect was observed when co-administered with the chemotherapy drug paclitaxel, reducing the cell viability to 42 %. These findings suggest potential therapeutic applications of the purified mushroom rhamnogalactan reported in this study against TNBC. [Display omitted] Mushroom-derived polysaccharides are known for their diverse biological activities, including immunomodulatory and anticancer properties. Breast cancer, the leading cause of cancer-related death among women worldwide, lacks targeted molecular therapies, underscoring the need for novel therapeutic agents. In this study, we extracted, purified, and characterized a novel heteropolysaccharide (HTP) - a rhamnogalactan - composed of galactose (72.6 %) and rhamnose (27.4 %) from the edible mushroom Lactarius quieticolor. Structural analysis revealed that HTP consists of a (1 → 6)-linked α-d-galactopyranose backbone, heavily substituted at O-2 by non-reducing rhamnose units, with a weight-average molar mass of 2.41 × 10 g.mol . In vitro assays using a triple-negative breast cancer (TNBC) cell model - the most aggressive subtype - showed a significant reduction in cell viability (50 % at 1200 μg·mL ). Furthermore, an additive effect was observed when co-administered with the chemotherapy drug paclitaxel, reducing the cell viability to 42 %. These findings suggest potential therapeutic applications of the purified mushroom rhamnogalactan reported in this study against TNBC. Mushroom-derived polysaccharides are known for their diverse biological activities, including immunomodulatory and anticancer properties. Breast cancer, the leading cause of cancer-related death among women worldwide, lacks targeted molecular therapies, underscoring the need for novel therapeutic agents. In this study, we extracted, purified, and characterized a novel heteropolysaccharide (HTP) - a rhamnogalactan - composed of galactose (72.6 %) and rhamnose (27.4 %) from the edible mushroom Lactarius quieticolor. Structural analysis revealed that HTP consists of a (1 → 6)-linked α-d-galactopyranose backbone, heavily substituted at O-2 by non-reducing rhamnose units, with a weight-average molar mass of 2.41 × 104 g.mol-1. In vitro assays using a triple-negative breast cancer (TNBC) cell model - the most aggressive subtype - showed a significant reduction in cell viability (50 % at 1200 μg·mL-1). Furthermore, an additive effect was observed when co-administered with the chemotherapy drug paclitaxel, reducing the cell viability to 42 %. These findings suggest potential therapeutic applications of the purified mushroom rhamnogalactan reported in this study against TNBC.Mushroom-derived polysaccharides are known for their diverse biological activities, including immunomodulatory and anticancer properties. Breast cancer, the leading cause of cancer-related death among women worldwide, lacks targeted molecular therapies, underscoring the need for novel therapeutic agents. In this study, we extracted, purified, and characterized a novel heteropolysaccharide (HTP) - a rhamnogalactan - composed of galactose (72.6 %) and rhamnose (27.4 %) from the edible mushroom Lactarius quieticolor. Structural analysis revealed that HTP consists of a (1 → 6)-linked α-d-galactopyranose backbone, heavily substituted at O-2 by non-reducing rhamnose units, with a weight-average molar mass of 2.41 × 104 g.mol-1. In vitro assays using a triple-negative breast cancer (TNBC) cell model - the most aggressive subtype - showed a significant reduction in cell viability (50 % at 1200 μg·mL-1). Furthermore, an additive effect was observed when co-administered with the chemotherapy drug paclitaxel, reducing the cell viability to 42 %. These findings suggest potential therapeutic applications of the purified mushroom rhamnogalactan reported in this study against TNBC. |
| ArticleNumber | 123735 |
| Author | Wurzer, Karin Maciel da Silva Milhorini, Shayane Klassen, Giseli Zavadinack, Matheus Cordeiro, Lucimara M.C. de Lara, Eliane Leal Iacomini, Marcello |
| Author_xml | – sequence: 1 givenname: Eliane Leal surname: de Lara fullname: de Lara, Eliane Leal organization: Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR CEP 81531-980, Brazil – sequence: 2 givenname: Matheus surname: Zavadinack fullname: Zavadinack, Matheus organization: Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR CEP 81531-980, Brazil – sequence: 3 givenname: Shayane surname: da Silva Milhorini fullname: da Silva Milhorini, Shayane organization: Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR CEP 81531-980, Brazil – sequence: 4 givenname: Karin Maciel surname: Wurzer fullname: Wurzer, Karin Maciel organization: Department of Basic Pathology, Federal University of Parana, Curitiba, PR CEP 81531-980, Brazil – sequence: 5 givenname: Giseli surname: Klassen fullname: Klassen, Giseli organization: Department of Basic Pathology, Federal University of Parana, Curitiba, PR CEP 81531-980, Brazil – sequence: 6 givenname: Lucimara M.C. surname: Cordeiro fullname: Cordeiro, Lucimara M.C. organization: Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR CEP 81531-980, Brazil – sequence: 7 givenname: Marcello surname: Iacomini fullname: Iacomini, Marcello email: iacomini@ufpr.br organization: Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR CEP 81531-980, Brazil |
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| Cites_doi | 10.1016/j.carbpol.2025.123318 10.1016/j.heliyon.2022.e12093 10.1016/j.polymdegradstab.2015.06.012 10.1016/j.carres.2005.08.012 10.1016/j.ijbiomac.2019.08.014 10.1016/S2095-3119(21)63871-6 10.1006/meth.2001.1262 10.3390/md13041819 10.3390/polym12081800 10.1016/j.rcl.2023.12.014 10.1016/j.ijbiomac.2019.11.066 10.4049/jimmunol.0903019 10.1016/j.fbio.2024.104277 10.1016/j.carbpol.2024.122171 10.3390/antiox10020312 10.3390/molecules26092776 10.1016/j.carbpol.2013.12.085 10.1016/j.phytochem.2012.08.010 10.1016/j.carbpol.2022.120533 10.3389/fonc.2022.985363 10.3390/agriculture2040452 10.1016/j.carbpol.2018.02.063 10.1016/j.foodhyd.2021.107392 10.1016/j.ijbiomac.2022.04.154 10.1016/j.carres.2006.01.002 10.1016/j.carbpol.2021.118647 10.1016/j.carbpol.2024.121978 10.1016/j.carbpol.2010.01.050 10.1111/bph.14816 10.1016/j.carbpol.2013.01.026 10.1016/j.carbpol.2022.119823 10.1016/j.jfda.2017.07.006 10.1016/j.ijbiomac.2024.130893 10.3892/ijo.2018.4661 10.1016/j.carbpol.2007.09.016 10.1016/j.jfca.2022.104970 10.1016/j.jfutfo.2022.09.003 10.1016/j.carbpol.2020.117177 10.1002/ijc.2910570616 10.1016/j.carbpol.2012.03.020 10.1038/s41598-021-82215-2 10.1016/j.nbt.2024.03.003 10.1016/j.carbpol.2015.08.020 10.1016/j.carres.2005.01.020 10.1016/j.carbpol.2008.09.028 10.1016/j.ijbiomac.2013.03.040 10.1016/j.ijbiomac.2021.10.049 10.1038/s41523-022-00468-0 10.1016/j.carbpol.2023.121678 10.1016/0008-6215(84)85242-8 10.1016/j.ijbiomac.2021.05.065 10.2147/NSA.S450026 10.1016/j.carbpol.2014.07.069 10.3390/foods14020246 10.1016/j.carbpol.2015.08.061 10.1016/0008-6215(84)85090-9 10.1016/j.jddst.2024.105567 10.1039/C5FO00678C 10.1016/j.fbio.2022.102124 10.1016/j.carbpol.2019.01.064 10.1039/c2fo10279j |
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| Keywords | Heteropolysaccharides Anticancer effect Lactarius quieticolor Rhamnogalactan Triple-negative breast cancer |
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| SubjectTerms | additive effect Agaricales - chemistry Anticancer effect Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology breast neoplasms Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects cell viability death drug therapy drugs Female Galactans - chemistry Galactans - isolation & purification Galactans - pharmacology galactose Heteropolysaccharides Humans Lactarius Lactarius quieticolor molecular weight mushrooms paclitaxel Paclitaxel - pharmacology polysaccharides Rhamnogalactan rhamnose Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - pathology Triple-negative breast cancer |
| Title | Structural characterization and anticancer properties of a novel mushroom-derived rhamnogalactan in a triple-negative breast cancer model |
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