Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism

Hyocholic acid (HCA) and its derivatives are found in trace amounts in human blood but constitute approximately 76% of the bile acid (BA) pool in pigs, a species known for its exceptional resistance to type 2 diabetes. Here, we show that BA depletion in pigs suppressed secretion of glucagon-like pep...

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Bibliographic Details
Published in:	Cell metabolism Vol. 33; no. 4; p. 791
Main Authors:	Zheng, Xiaojiao, Chen, Tianlu, Jiang, Runqiu, Zhao, Aihua, Wu, Qing, Kuang, Junliang, Sun, Dongnan, Ren, Zhenxing, Li, Mengci, Zhao, Mingliang, Wang, Shouli, Bao, Yuqian, Li, Huating, Hu, Cheng, Dong, Bing, Li, Defa, Wu, Jiayu, Xia, Jialin, Wang, Xuemei, Lan, Ke, Rajani, Cynthia, Xie, Guoxiang, Lu, Aiping, Jia, Weiping, Jiang, Changtao, Jia, Wei
Format:	Journal Article
Language:	English
Published:	United States 06.04.2021
Subjects:	Animals Blood Glucose - analysis Cell Line Cholic Acids - blood Cholic Acids - chemistry Cholic Acids - pharmacology Cholic Acids - therapeutic use Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - pathology Glucagon-Like Peptide 1 - metabolism Glucagon-Like Peptide-1 Receptor - antagonists & inhibitors Glucagon-Like Peptide-1 Receptor - metabolism Glucose - metabolism Humans Isoxazoles - pharmacology Male Mice Mice, Inbred C57BL Mice, Knockout Receptors, Cytoplasmic and Nuclear - metabolism Receptors, G-Protein-Coupled - deficiency Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Signal Transduction - drug effects Swine FXR TGR5 glucose homeostasis insulin bile acid glucagon-like peptide-1 hyodeoxycholic acid hyocholic acid diabetes pig
ISSN:	1932-7420, 1932-7420
Online Access:	Get more information
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