Transcriptional landscapes underlying Notch-induced lineage conversion and plasticity of mammary basal cells

The mammary epithelium derives from multipotent mammary stem cells (MaSCs) that engage into differentiation during embryonic development. However, adult MaSCs maintain the ability to reactivate multipotency in non-physiological contexts. We previously reported that Notch1 activation in committed bas...

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Bibliographic Details
Published in:	The EMBO journal Vol. 44; no. 10; pp. 2827 - 2855
Main Authors:	Merle, Candice, Rodrigues, Calvin, Pourkhalili Langeroudi, Atefeh, Journot, Robin, Rost, Fabian, Dang, Yiteng, Rulands, Steffen, Fre, Silvia
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 16.05.2025
Subjects:	Animals Biomedical and Life Sciences Cell Differentiation Cell Lineage Cell Plasticity Cell Proliferation EMBO09 EMBO11 EMBO34 Epithelial Cells - cytology Epithelial Cells - metabolism Female Life Sciences Mammary Glands, Animal - cytology Mammary Glands, Animal - metabolism Mice Receptor, Notch1 - genetics Receptor, Notch1 - metabolism Signal Transduction Single-Cell Analysis Transcriptome Lineage Conversion Notch1 Signaling Epithelial Stem Cells Plasticity
ISSN:	1460-2075, 0261-4189, 1460-2075
Online Access:	Get full text
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