The entry of nanoparticles into solid tumours

The concept of nanoparticle transport through gaps between endothelial cells (inter-endothelial gaps) in the tumour blood vessel is a central paradigm in cancer nanomedicine. The size of these gaps was found to be up to 2,000 nm. This justified the development of nanoparticles to treat solid tumours...

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Bibliographic Details
Published in:	Nature materials Vol. 19; no. 5; pp. 566 - 575
Main Authors:	Sindhwani, Shrey, Syed, Abdullah Muhammad, Ngai, Jessica, Kingston, Benjamin R., Maiorino, Laura, Rothschild, Jeremy, MacMillan, Presley, Zhang, Yuwei, Rajesh, Netra Unni, Hoang, Tran, Wu, Jamie L. Y., Wilhelm, Stefan, Zilman, Anton, Gadde, Suresh, Sulaiman, Andrew, Ouyang, Ben, Lin, Zachary, Wang, Lisheng, Egeblad, Mikala, Chan, Warren C. W.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.05.2020 Nature Publishing Group
Subjects:	631/67/327 639/301/357/354 639/925/352/2733 639/925/930/2735 Animals Biomaterials Blood vessels Cancer Cell Line, Tumor Chemistry and Materials Science Computer simulation Condensed Matter Physics Endothelial cells Gold - chemistry Gold - pharmacokinetics Gold - pharmacology Humans Imaging techniques Materials Science Metal Nanoparticles - chemistry Metal Nanoparticles - therapeutic use Mice Mice, Inbred BALB C Models, Biological Nanoparticles Nanotechnology Neoplasms, Experimental - drug therapy Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Optical and Electronic Materials Transport Tumor Microenvironment - drug effects Tumors Xenograft Model Antitumor Assays
ISSN:	1476-1122, 1476-4660, 1476-4660
Online Access:	Get full text
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