Standardization of Laboratory Methods for the PERCH Study

The Pneumonia Etiology Research for Child Health study was conducted across 7 diverse research sites and relied on standardized clinical and laboratory methods for the accurate and meaningful interpretation of pneumonia etiology data. Blood, respiratory specimens, and urine were collected from child...

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Vydáno v:Clinical infectious diseases Ročník 64; číslo suppl_3; s. S245
Hlavní autoři: Driscoll, Amanda J, Karron, Ruth A, Morpeth, Susan C, Bhat, Niranjan, Levine, Orin S, Baggett, Henry C, Brooks, W Abdullah, Feikin, Daniel R, Hammitt, Laura L, Howie, Stephen R C, Knoll, Maria Deloria, Kotloff, Karen L, Madhi, Shabir A, Scott, J Anthony G, Thea, Donald M, Adrian, Peter V, Ahmed, Dilruba, Alam, Muntasir, Anderson, Trevor P, Antonio, Martin, Baillie, Vicky L, Dione, Michel, Endtz, Hubert P, Gitahi, Caroline, Karani, Angela, Kwenda, Geoffrey, Maiga, Abdoul Aziz, McClellan, Jessica, Mitchell, Joanne L, Morailane, Palesa, Mugo, Daisy, Mwaba, John, Mwansa, James, Mwarumba, Salim, Nyongesa, Sammy, Panchalingam, Sandra, Rahman, Mustafizur, Sawatwong, Pongpun, Tamboura, Boubou, Toure, Aliou, Whistler, Toni, O'Brien, Katherine L, Murdoch, David R
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 15.06.2017
Témata:
Algorithms
Child, Preschool
Clinical Laboratory Techniques - standards
Data Accuracy
Female
HIV Infections
Humans
Infant
Male
Pneumonia - diagnosis
Pneumonia - etiology
Pneumonia, Bacterial - diagnosis
Pneumonia, Viral - diagnosis
Quality Control
Reference Standards
Respiratory Tract Infections - etiology
Specimen Handling - standards
pneumonia
PERCH
laboratory
respiratory infection
ISSN:1537-6591, 1537-6591
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Shrnutí:The Pneumonia Etiology Research for Child Health study was conducted across 7 diverse research sites and relied on standardized clinical and laboratory methods for the accurate and meaningful interpretation of pneumonia etiology data. Blood, respiratory specimens, and urine were collected from children aged 1-59 months hospitalized with severe or very severe pneumonia and community controls of the same age without severe pneumonia and were tested with an extensive array of laboratory diagnostic tests. A standardized testing algorithm and standard operating procedures were applied across all study sites. Site laboratories received uniform training, equipment, and reagents for core testing methods. Standardization was further assured by routine teleconferences, in-person meetings, site monitoring visits, and internal and external quality assurance testing. Targeted confirmatory testing and testing by specialized assays were done at a central reference laboratory.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1537-6591
1537-6591
DOI:10.1093/cid/cix081