The Cyclops for pulmonary delivery of aminoglycosides; a new member of the Twincer™ family

[Display omitted] •Aminoglycosides are hygroscopic drugs with poor dispersion and retention properties.•Tobramycin moisture sorption is much higher for the sulfate than for the free base.•Pure aminoglycoside powders can be dispersed efficiently with a proper DPI design.•A high resistance reduces oro...

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Bibliographic Details
Published in:	European journal of pharmaceutics and biopharmaceutics Vol. 90; pp. 8 - 15
Main Authors:	Hoppentocht, M., Akkerman, O.W., Hagedoorn, P., Frijlink, H.W., de Boer, A.H.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.02.2015
Subjects:	Administration, Inhalation Aminoglycosides Aminoglycosides - administration & dosage Aminoglycosides - chemistry Antibiotics Cystic fibrosis Disposable inhaler Drug Compounding - methods Drug Delivery Systems - methods Dry powder dispersion Dry Powder Inhalers - methods Excipients - administration & dosage Excipients - chemistry High drug dose Lung - metabolism Minocycline - administration & dosage Minocycline - chemistry Nebulizers and Vaporizers Particle Size Powders - administration & dosage Powders - chemistry Technology, Pharmaceutical - methods Tobramycin - administration & dosage Tobramycin - chemistry Tuberculosis PSD High drug dose CF Disposable inhaler Aminoglycosides Cystic fibrosis TB TNBSA Dry powder dispersion Tuberculosis Antibiotics RH DPI FPF Psa
ISSN:	0939-6411, 1873-3441, 1873-3441
Online Access:	Get full text
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