Effects of itraconazole and rifampicin on the pharmacokinetics and safety of youkenafil, a novel phosphodiesterase type 5 inhibitor, in healthy Chinese subjects

•First report of in vivo and in vitro drug interaction studies on youkenafil.•First report of youkenafil pharmacokinetic parameters in healthy Chinese subjects.•Itraconazole and rifampicin have significant clinical effect on youkenafil. Youkenafil is a novel selective phosphodiesterase type 5 inhibi...

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