Synergy between the KEAP1/NRF2 and PI3K Pathways Drives Non-Small-Cell Lung Cancer with an Altered Immune Microenvironment

The lung presents a highly oxidative environment, which is tolerated through engagement of tightly controlled stress response pathways. A critical stress response mediator is the transcription factor nuclear factor erythroid-2-related factor 2 (NFE2L2/NRF2), which is negatively regulated by Kelch-li...

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Bibliographic Details
Published in:	Cell metabolism Vol. 27; no. 4; p. 935
Main Authors:	Best, Sarah A, De Souza, David P, Kersbergen, Ariena, Policheni, Antonia N, Dayalan, Saravanan, Tull, Dedreia, Rathi, Vivek, Gray, Daniel H, Ritchie, Matthew E, McConville, Malcolm J, Sutherland, Kate D
Format:	Journal Article
Language:	English
Published:	United States 03.04.2018
Subjects:	Adenocarcinoma of Lung - immunology Adenocarcinoma of Lung - metabolism Animals Carcinogenesis Carcinoma, Non-Small-Cell Lung - immunology Carcinoma, Non-Small-Cell Lung - metabolism Gene Expression Regulation, Neoplastic Humans Kelch-Like ECH-Associated Protein 1 - genetics Kelch-Like ECH-Associated Protein 1 - metabolism Kelch-Like ECH-Associated Protein 1 - physiology Loss of Function Mutation Lung Neoplasms - immunology Lung Neoplasms - metabolism Mice, Mutant Strains NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism NF-E2-Related Factor 2 - physiology Pentose Phosphate Pathway Phosphatidylinositol 3-Kinases - metabolism PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism PTEN Phosphohydrolase - physiology Keap1 PD-L1 Pten Nrf2 Taldo1 non-small-cell lung cancer
ISSN:	1932-7420, 1932-7420
Online Access:	Get more information
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