Validation of Strasbourg environmental exposure chamber (EEC) ALYATEC® in mite allergic subjects with asthma

Objective: Environmental Exposure Chamber (EEC) should have standardized and controlled allergenic and non-allergenic exposures to perform reproducible clinical studies. The aim was to demonstrate that mite exposure in the Alyatec ® EEC could induce early (EAR) and/or late asthmatic reactions (LAR)...

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Vydané v:	The Journal of asthma Ročník 57; číslo 2; s. 140 - 148
Hlavní autori:	Khayath, Naji, Doyen, Virginie, Gherasim, Alina, Radu, Carmen, Choual, Ibrahim, Beck, Nicole, Jacob, Audrey, Schoettel, Florian, Vecellio, Laurent, Domis, Nathalie, de Blay, Frédéric
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Taylor & Francis 01.02.2020 Informa Healthcare
Predmet:	asthma early asthmatic response environmental experimental chamber Environmental Sciences Human health and pathology late asthmatic response Life Sciences Mite Pulmonology and respiratory tract Santé publique et épidémiologie Mite asthma environmental experimental chamber late asthmatic response early asthmatic response
ISSN:	0277-0903, 1532-4303, 1532-4303
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Popis
Shrnutí:	Objective: Environmental Exposure Chamber (EEC) should have standardized and controlled allergenic and non-allergenic exposures to perform reproducible clinical studies. The aim was to demonstrate that mite exposure in the Alyatec ® EEC could induce early (EAR) and/or late asthmatic reactions (LAR) in at least 60% of subjects allergic to mite. Methods: The EEC has a volume of 147-m 3 with 20 seats. The nebulized particle number, airborne Der p1, endotoxins, and volatile organic compound (VOC) concentrations were measured. Twenty-four asthmatics allergic to mite were randomly exposed to 15, 25, and 46 ng/m 3 Der p1. Specificity was assessed in not mite-sensitized asthmatics. Results: No significant endotoxin or VOC contamination was measured. The mean inter-assay CVs were 12.5% for the airborne particle number and 28.7% for airborne Der p1 concentrations. For the three Der p1 concentrations, at least 88% of the subjects developed EAR and/or LAR, and at least 46% developed a dual response. No reaction occurred with placebo or in the control group. No severe bronchial reaction occurred. Conclusions: The Alyatec ® EEC demonstrated a tight control of allergenic and non-allergenic exposures. The EEC was clinically validated, with airborne Der p1 levels close to levels found in natural settings.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3
ISSN:	0277-0903 1532-4303 1532-4303
DOI:	10.1080/02770903.2018.1563902