Air-liquid interface (ALI) impact on different respiratory cell cultures
[Display omitted] The intranasal route has been receiving greater attention from the scientific community not only for systemic drug delivery but also for the treatment of pulmonary and neurological diseases. Along with it, drug transport and permeability studies across the nasal mucosa have exponen...
Gespeichert in:
| Veröffentlicht in: | European journal of pharmaceutics and biopharmaceutics Jg. 184; S. 62 - 82 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
Netherlands
Elsevier B.V
01.03.2023
|
| Schlagworte: | |
| ISSN: | 0939-6411, 1873-3441, 1873-3441 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | [Display omitted]
The intranasal route has been receiving greater attention from the scientific community not only for systemic drug delivery but also for the treatment of pulmonary and neurological diseases. Along with it, drug transport and permeability studies across the nasal mucosa have exponentially increased. Nevertheless, the translation of data from in vitro cell lines to in vivo studies is not always reliable, due to the difficulty in generating an in vitro model that resembles respiratory human physiology. Among all currently available methodologies, the air–liquid interface (ALI) method is advantageous to promote cell differentiation and optimize the morphological and histological characteristics of airway epithelium cells. Cells grown under ALI conditions, in alternative to submerged conditions, appear to provide relevant input for inhalation and pulmonary toxicology and complement in vivo experiments. Different methodologies and a variety of materials have been used to induce ALI conditions in primary cells and numerous cell lines. Until this day, with only exploratory results, no consensus has been reached regarding the validation of the ALI method, hampering data comparison. The present review describes the most adequate cell models of airway epithelium and how these models are differently affected by ALI conditions. It includes the evaluation of cellular features before and after ALI, and the application of the method in primary cell cultures, commercial 3D primary cells, cell lines and stem-cell derived models. A variety of these models have been recently applied for pharmacological studies against severe acute respiratory syndrome–coronavirus(-2) SARS-CoV(-2), namely primary cultures with alveolar type II epithelium cells and organotypic 3D models. The herein compiled data suggest that ALI conditions must be optimized bearing in mind the type of cells (nasal, bronchial, alveolar), their origin and the objective of the study. |
|---|---|
| AbstractList | [Display omitted]
The intranasal route has been receiving greater attention from the scientific community not only for systemic drug delivery but also for the treatment of pulmonary and neurological diseases. Along with it, drug transport and permeability studies across the nasal mucosa have exponentially increased. Nevertheless, the translation of data from in vitro cell lines to in vivo studies is not always reliable, due to the difficulty in generating an in vitro model that resembles respiratory human physiology. Among all currently available methodologies, the air–liquid interface (ALI) method is advantageous to promote cell differentiation and optimize the morphological and histological characteristics of airway epithelium cells. Cells grown under ALI conditions, in alternative to submerged conditions, appear to provide relevant input for inhalation and pulmonary toxicology and complement in vivo experiments. Different methodologies and a variety of materials have been used to induce ALI conditions in primary cells and numerous cell lines. Until this day, with only exploratory results, no consensus has been reached regarding the validation of the ALI method, hampering data comparison. The present review describes the most adequate cell models of airway epithelium and how these models are differently affected by ALI conditions. It includes the evaluation of cellular features before and after ALI, and the application of the method in primary cell cultures, commercial 3D primary cells, cell lines and stem-cell derived models. A variety of these models have been recently applied for pharmacological studies against severe acute respiratory syndrome–coronavirus(-2) SARS-CoV(-2), namely primary cultures with alveolar type II epithelium cells and organotypic 3D models. The herein compiled data suggest that ALI conditions must be optimized bearing in mind the type of cells (nasal, bronchial, alveolar), their origin and the objective of the study. The intranasal route has been receiving greater attention from the scientific community not only for systemic drug delivery but also for the treatment of pulmonary and neurological diseases. Along with it, drug transport and permeability studies across the nasal mucosa have exponentially increased. Nevertheless, the translation of data from in vitro cell lines to in vivo studies is not always reliable, due to the difficulty in generating an in vitro model that resembles respiratory human physiology. Among all currently available methodologies, the air-liquid interface (ALI) method is advantageous to promote cell differentiation and optimize the morphological and histological characteristics of airway epithelium cells. Cells grown under ALI conditions, in alternative to submerged conditions, appear to provide relevant input for inhalation and pulmonary toxicology and complement in vivo experiments. Different methodologies and a variety of materials have been used to induce ALI conditions in primary cells and numerous cell lines. Until this day, with only exploratory results, no consensus has been reached regarding the validation of the ALI method, hampering data comparison. The present review describes the most adequate cell models of airway epithelium and how these models are differently affected by ALI conditions. It includes the evaluation of cellular features before and after ALI, and the application of the method in primary cell cultures, commercial 3D primary cells, cell lines and stem-cell derived models. A variety of these models have been recently applied for pharmacological studies against severe acute respiratory syndrome-coronavirus(-2) SARS-CoV(-2), namely primary cultures with alveolar type II epithelium cells and organotypic 3D models. The herein compiled data suggest that ALI conditions must be optimized bearing in mind the type of cells (nasal, bronchial, alveolar), their origin and the objective of the study. The intranasal route has been receiving greater attention from the scientific community not only for systemic drug delivery but also for the treatment of pulmonary and neurological diseases. Along with it, drug transport and permeability studies across the nasal mucosa have exponentially increased. Nevertheless, the translation of data from in vitro cell lines to in vivo studies is not always reliable, due to the difficulty in generating an in vitro model that resembles respiratory human physiology. Among all currently available methodologies, the air-liquid interface (ALI) method is advantageous to promote cell differentiation and optimize the morphological and histological characteristics of airway epithelium cells. Cells grown under ALI conditions, in alternative to submerged conditions, appear to provide relevant input for inhalation and pulmonary toxicology and complement in vivo experiments. Different methodologies and a variety of materials have been used to induce ALI conditions in primary cells and numerous cell lines. Until this day, with only exploratory results, no consensus has been reached regarding the validation of the ALI method, hampering data comparison. The present review describes the most adequate cell models of airway epithelium and how these models are differently affected by ALI conditions. It includes the evaluation of cellular features before and after ALI, and the application of the method in primary cell cultures, commercial 3D primary cells, cell lines and stem-cell derived models. A variety of these models have been recently applied for pharmacological studies against severe acute respiratory syndrome-coronavirus(-2) SARS-CoV(-2), namely primary cultures with alveolar type II epithelium cells and organotypic 3D models. The herein compiled data suggest that ALI conditions must be optimized bearing in mind the type of cells (nasal, bronchial, alveolar), their origin and the objective of the study.The intranasal route has been receiving greater attention from the scientific community not only for systemic drug delivery but also for the treatment of pulmonary and neurological diseases. Along with it, drug transport and permeability studies across the nasal mucosa have exponentially increased. Nevertheless, the translation of data from in vitro cell lines to in vivo studies is not always reliable, due to the difficulty in generating an in vitro model that resembles respiratory human physiology. Among all currently available methodologies, the air-liquid interface (ALI) method is advantageous to promote cell differentiation and optimize the morphological and histological characteristics of airway epithelium cells. Cells grown under ALI conditions, in alternative to submerged conditions, appear to provide relevant input for inhalation and pulmonary toxicology and complement in vivo experiments. Different methodologies and a variety of materials have been used to induce ALI conditions in primary cells and numerous cell lines. Until this day, with only exploratory results, no consensus has been reached regarding the validation of the ALI method, hampering data comparison. The present review describes the most adequate cell models of airway epithelium and how these models are differently affected by ALI conditions. It includes the evaluation of cellular features before and after ALI, and the application of the method in primary cell cultures, commercial 3D primary cells, cell lines and stem-cell derived models. A variety of these models have been recently applied for pharmacological studies against severe acute respiratory syndrome-coronavirus(-2) SARS-CoV(-2), namely primary cultures with alveolar type II epithelium cells and organotypic 3D models. The herein compiled data suggest that ALI conditions must be optimized bearing in mind the type of cells (nasal, bronchial, alveolar), their origin and the objective of the study. |
| Author | Silva, Soraia Falcão, Amílcar Bicker, Joana Fortuna, Ana |
| Author_xml | – sequence: 1 givenname: Soraia surname: Silva fullname: Silva, Soraia – sequence: 2 givenname: Joana surname: Bicker fullname: Bicker, Joana – sequence: 3 givenname: Amílcar surname: Falcão fullname: Falcão, Amílcar – sequence: 4 givenname: Ana orcidid: 0000-0001-6981-6639 surname: Fortuna fullname: Fortuna, Ana email: anacfortuna@gmail.com, afortuna@ff.uc.pt |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36696943$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kE1LAzEQhoNU7If-AQ-yx3rYmmzSbAJeSlFbKHjRc8gms5Cy3d0mWaH_3l1aPXgQBgaG5xlm3ika1U0NCN0TvCCY8Kf9AvZtschwRheY9EWv0ISInKaUMTJCEyypTDkjZIymIewxxixfihs0ppxLLhmdoM3K-bRyx87ZxNURfKkNJPPVbvuYuEOrTUyaOrGuLMFDHRMPoXVex8afEgNVlZiuil0_vUXXpa4C3F36DH2-vnysN-nu_W27Xu1SwzCOKcO2EHopSC4MNaUQwuaFpUsAyDUXhAvQOTcGY2qzIpPALGMZy4UsMwN4SWdoft7b-ubYQYjq4MJwia6h6YLKci6lpIwM6MMF7YoDWNV6d9D-pH6-74HsDBjfhOCh_EUIVkPEaq-GiNUQscKkr0ESfyTjoo6uqaPXrvpffT6r0Af05cCrYBzUBqzzYKKyjftP_waREJXa |
| CitedBy_id | crossref_primary_10_1016_j_antiviral_2025_106174 crossref_primary_10_1080_17425247_2024_2446608 crossref_primary_10_1186_s12931_024_02686_5 crossref_primary_10_3389_fcimb_2025_1552395 crossref_primary_10_1093_femsre_fuae007 crossref_primary_10_1016_j_tiv_2025_106122 crossref_primary_10_1016_j_cell_2023_08_011 crossref_primary_10_1208_s12248_024_00967_x crossref_primary_10_3389_fcimb_2024_1389527 crossref_primary_10_1016_j_jconrel_2025_114053 crossref_primary_10_1016_j_cotox_2025_100529 crossref_primary_10_1016_j_ijpharm_2023_123252 crossref_primary_10_1016_j_tiv_2023_105718 crossref_primary_10_1017_erm_2025_7 crossref_primary_10_3389_fphar_2025_1579551 crossref_primary_10_1021_acsbiomaterials_4c01322 crossref_primary_10_1021_acsami_5c01920 crossref_primary_10_1016_j_atherosclerosis_2024_118529 crossref_primary_10_1152_ajplung_00380_2024 crossref_primary_10_1016_j_tiv_2024_105889 crossref_primary_10_1002_bit_28552 crossref_primary_10_1155_2023_4694243 crossref_primary_10_3390_v17050703 crossref_primary_10_3389_fmicb_2024_1507852 crossref_primary_10_1016_j_envint_2024_108889 crossref_primary_10_1016_j_ejphar_2025_177636 crossref_primary_10_3390_ijms26052287 crossref_primary_10_1186_s12931_024_03060_1 crossref_primary_10_1002_alr_23487 crossref_primary_10_1016_j_etap_2023_104353 crossref_primary_10_1128_msphere_00365_25 crossref_primary_10_3390_cells13231991 crossref_primary_10_3390_pharmaceutics15102439 crossref_primary_10_1002_mco2_494 crossref_primary_10_1016_j_ejps_2023_106596 crossref_primary_10_1007_s10565_024_09860_x crossref_primary_10_1021_acsomega_5c03198 crossref_primary_10_1371_journal_pone_0300772 crossref_primary_10_1098_rsob_240231 crossref_primary_10_1165_rcmb_2024_0166ED crossref_primary_10_1016_j_chemosphere_2024_143702 crossref_primary_10_1007_s43188_025_00315_x crossref_primary_10_3390_ijms25179394 crossref_primary_10_1088_1758_5090_ad663d crossref_primary_10_3390_ijms26115027 crossref_primary_10_1007_s11356_024_34905_3 crossref_primary_10_1016_j_jcyt_2024_12_005 crossref_primary_10_1016_j_chemosphere_2024_143417 crossref_primary_10_2903_sp_efsa_2024_EN_8826 crossref_primary_10_3390_jpm14010109 crossref_primary_10_1111_bcpt_14036 crossref_primary_10_1016_j_tox_2023_153683 crossref_primary_10_1038_s41598_025_00438_z crossref_primary_10_3389_frph_2024_1490520 crossref_primary_10_3390_ijms25094671 crossref_primary_10_3390_life15060958 crossref_primary_10_1039_D5NR00870K crossref_primary_10_1002_jat_4891 crossref_primary_10_1038_s41598_025_07219_8 crossref_primary_10_1016_j_tiv_2025_106060 crossref_primary_10_1016_j_envres_2025_122289 crossref_primary_10_1016_j_envres_2025_122762 crossref_primary_10_1016_j_tox_2025_154060 crossref_primary_10_1183_23120541_00703_2024 crossref_primary_10_1016_j_scitotenv_2025_178435 crossref_primary_10_3390_ijms25137113 crossref_primary_10_1080_02786826_2024_2426487 |
| Cites_doi | 10.1080/08958370802555898 10.1165/rcmb.2011-0220OC 10.3109/08958378.2016.1157227 10.1023/A:1026112107100 10.1042/BSR20130109 10.1021/js9803205 10.1016/j.tiv.2014.10.024 10.1016/j.jaerosci.2015.12.006 10.1038/sj.bjp.0704390 10.1016/j.cell.2020.10.049 10.1016/j.taap.2015.06.008 10.1177/000348940111001104 10.1016/0887-2333(87)90005-1 10.3390/pharmaceutics12020138 10.1371/journal.pone.0135690 10.14573/altex.1607191 10.1177/000348940010900612 10.1111/imr.12020 10.1023/A:1018869601502 10.1016/j.bbrc.2004.05.101 10.1038/s41598-018-36735-z 10.3390/pharmaceutics11080367 10.1101/2020.06.29.174623 10.1056/NEJMp2030646 10.3791/51539-v 10.1089/jamp.2009.0757 10.1021/acs.molpharmaceut.5b00103 10.1016/j.ejpb.2019.04.002 10.1016/j.ejps.2005.07.010 10.1021/bm800975j 10.3791/51046-v 10.1111/j.2042-7158.2010.01221.x 10.1101/2021.01.05.21249237 10.1023/A:1018911206646 10.1177/009127002762491370 10.1016/j.ijpharm.2011.12.028 10.1248/bpb.b14-00398 10.3109/01902148609061488 10.1021/mp200620m 10.1093/toxsci/kfx255 10.1371/journal.pone.0165225 10.1165/rcmb.2004-0220RC 10.1165/rcmb.2013-0237OC 10.1111/j.2042-7158.2012.01540.x 10.1089/jam.2006.19.392 10.1124/dmd.105.005769 10.1152/ajplung.00357.2017 10.1038/nprot.2007.303 10.1152/ajplung.00169.2005 10.1016/j.ejpb.2018.05.009 10.1186/1743-8977-10-31 10.1002/jps.23606 10.1165/ajrcmb.17.5.2685 10.1021/acsnano.9b06860 10.1006/excr.1998.4172 10.3390/nano10122369 10.1002/jps.20803 10.1016/j.ijpharm.2016.09.086 10.1007/s11095-014-1494-0 10.1002/biot.201700341 10.14573/altex.1511131 10.1016/j.ijpharm.2016.05.010 10.1016/j.ijpharm.2009.10.043 10.1021/es051043o 10.1016/j.ijpharm.2020.120161 10.4049/jimmunol.1003377 10.1371/journal.pone.0164438 10.1089/aivt.2017.0034 10.1186/1465-9921-10-105 10.1111/j.1749-6632.2012.06539.x 10.1016/j.ejps.2010.02.002 10.1038/s42003-021-01695-0 10.1016/j.ejpb.2008.09.006 10.1016/j.pharmthera.2008.11.001 10.1007/s00418-018-1747-9 10.1021/acs.molpharmaceut.8b00087 10.1016/j.ijpharm.2010.08.030 10.1016/j.biomaterials.2013.10.018 10.3109/08958378.2015.1066903 10.1016/S0928-0987(02)00240-3 10.1038/srep08163 10.1183/09031936.01.00229701 10.2307/3579855 10.1002/1520-6017(200105)90:5<647::AID-JPS1021>3.0.CO;2-G 10.1016/S0940-2993(00)80044-5 10.3390/ijms21093190 10.1186/1743-8977-6-32 10.1016/j.tox.2004.10.014 10.1016/j.tiv.2014.12.023 10.1007/s10616-012-9493-7 10.1080/10717540500177009 10.1211/jpp.61.05.0006 10.1165/rcmb.2013-0090OC 10.1152/ajplung.00190.2019 10.1165/rcmb.2013-0188OC 10.1016/S0928-0987(97)10019-7 10.1016/j.ejpb.2019.05.022 10.1038/srep37842 10.1016/j.ijpharm.2006.08.043 10.1016/j.immuni.2019.03.018 10.1165/ajrcmb.11.5.7946385 10.1038/labinvest.3700081 10.5487/TR.2015.31.2.181 10.1038/s41598-020-63922-8 10.1016/j.ejpb.2020.04.011 10.3390/pharmaceutics12111025 10.1016/j.tiv.2013.06.016 10.2478/v10007-009-0038-3 10.1002/jps.21031 10.1165/ajrcmb.10.1.7507342 10.1007/s00204-016-1717-8 10.1089/aivt.2014.0003 10.1165/rcmb.2008-0228OC 10.1016/j.ejpb.2009.08.008 10.1038/s41598-020-63265-4 10.1208/s12248-020-00531-3 10.1146/annurev-cellbio-100617-062818 10.1016/j.tiv.2013.10.025 10.1038/s41586-020-2558-4 10.1101/2020.06.03.132639 10.3390/pharmaceutics10020056 10.1080/08958370490258381 10.1016/j.toxlet.2015.09.003 10.1513/pats.200805-041HR 10.4049/jimmunol.175.10.6676 10.1016/j.toxlet.2014.06.021 10.1016/j.vascn.2019.04.002 10.1007/978-1-4020-6364-0_31 10.1016/j.ijpharm.2017.09.027 10.1016/j.ejpb.2016.07.010 10.1002/jps.22314 10.1007/BF02634112 10.1002/jps.24381 10.1007/s11882-020-00958-w 10.1023/A:1023230328687 10.3390/biom12091260 10.1165/rcmb.2009-0359OC 10.1016/j.addr.2011.11.002 10.1155/2013/652632 10.1016/j.tiv.2017.09.016 10.1002/1873-3468.12026 10.1186/s12985-020-01401-2 10.1021/mp4006535 10.1165/ajrcmb.19.1.3054 10.1016/j.tiv.2012.10.010 10.1371/journal.pone.0170428 10.3390/pharmaceutics12010079 10.3762/bjnano.5.149 10.1016/j.ebiom.2014.12.005 10.1165/rcmb.2012-0339OC 10.1016/j.tiv.2012.08.030 10.1186/s13223-017-0209-6 10.1016/j.tiv.2015.06.016 10.1183/09031936.97.10081837 10.1371/journal.pone.0032924 10.1124/dmd.112.046896 10.1186/1743-8977-10-25 10.1016/j.ejpb.2010.12.030 10.1016/j.ejpb.2016.12.006 10.1177/0261192919841484 10.1021/acs.molpharmaceut.6b00838 10.1002/mabi.201100181 10.1038/s41598-017-18561-x 10.1165/ajrcmb.25.2.4211 10.1007/s11095-006-0255-0 10.1016/j.ijpharm.2011.12.036 |
| ContentType | Journal Article |
| Copyright | 2023 The Authors Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved. |
| Copyright_xml | – notice: 2023 The Authors – notice: Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved. |
| DBID | 6I. AAFTH AAYXX CITATION NPM 7X8 |
| DOI | 10.1016/j.ejpb.2023.01.013 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1873-3441 |
| EndPage | 82 |
| ExternalDocumentID | 36696943 10_1016_j_ejpb_2023_01_013 S0939641123000139 |
| Genre | Journal Article Review |
| GroupedDBID | --- --K --M .~1 0R~ 1B1 1RT 1~. 1~5 29G 4.4 457 4G. 53G 5GY 5VS 6I. 7-5 71M 8P~ AABNK AACTN AAEDT AAEDW AAFTH AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATCM AAXUO AAYOK ABFNM ABFRF ABGSF ABJNI ABMAC ABUDA ABXDB ABYKQ ABZDS ACDAQ ACGFO ACIUM ACRLP ADBBV ADEZE ADMUD ADUVX AEBSH AEFWE AEHWI AEKER AENEX AFKWA AFTJW AFXIZ AGHFR AGRDE AGUBO AGYEJ AIEXJ AIKHN AITUG AJBFU AJOXV ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC C45 CS3 DOVZS DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 FDB FEDTE FGOYB FIRID FNPLU FYGXN G-Q GBLVA HVGLF HZ~ IHE J1W KOM M41 MO0 N9A O-L O9- OAUVE OGGZJ OVD OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SDF SDG SES SEW SPCBC SSP SSU SSZ T5K TEORI UNMZH ~G- 9DU AATTM AAXKI AAYWO AAYXX ABWVN ACLOT ACRPL ACVFH ADCNI ADNMO AEIPS AEUPX AFJKZ AFPUW AGQPQ AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP CITATION EFKBS ~HD NPM 7X8 |
| ID | FETCH-LOGICAL-c400t-40db8a58178c3cf888d7bd35eee7a68168ea76cc003d2b29e4d4424789f2ce053 |
| ISICitedReferencesCount | 84 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000964928800001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0939-6411 1873-3441 |
| IngestDate | Thu Oct 02 07:47:34 EDT 2025 Wed Feb 19 02:24:29 EST 2025 Tue Nov 18 22:46:15 EST 2025 Sat Nov 29 07:07:46 EST 2025 Fri Feb 23 02:38:40 EST 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | OCT ABC HBE MRP EGFR LPS ASF TBE CYP hESC BCRP Pulmonary administration IL P-gp iPSC SARS-CoV(-2) Air-liquid interface Intranasal administration Airway epithelium Primary cells Papp ZO Cell lines TEER ALI HNE PET HPMEC |
| Language | English |
| License | This is an open access article under the CC BY-NC-ND license. Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c400t-40db8a58178c3cf888d7bd35eee7a68168ea76cc003d2b29e4d4424789f2ce053 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| ORCID | 0000-0001-6981-6639 |
| OpenAccessLink | https://dx.doi.org/10.1016/j.ejpb.2023.01.013 |
| PMID | 36696943 |
| PQID | 2769993415 |
| PQPubID | 23479 |
| PageCount | 21 |
| ParticipantIDs | proquest_miscellaneous_2769993415 pubmed_primary_36696943 crossref_primary_10_1016_j_ejpb_2023_01_013 crossref_citationtrail_10_1016_j_ejpb_2023_01_013 elsevier_sciencedirect_doi_10_1016_j_ejpb_2023_01_013 |
| PublicationCentury | 2000 |
| PublicationDate | March 2023 2023-03-00 2023-Mar 20230301 |
| PublicationDateYYYYMMDD | 2023-03-01 |
| PublicationDate_xml | – month: 03 year: 2023 text: March 2023 |
| PublicationDecade | 2020 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | European journal of pharmaceutics and biopharmaceutics |
| PublicationTitleAlternate | Eur J Pharm Biopharm |
| PublicationYear | 2023 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Clippinger, Ahluwalia, Allen, Bonner, Casey, Castranova, David, Halappanavar, Hotchkiss, Jarabek, Maier, Polk, Rothen-Rutishauser, Sayes, Sayre, Sharma, Stone (b0020) 2016; 90 Lin, Li, Cho, Bian, Roh, Lee, Kim, Chung, Shim, Kim (b0380) 2007; 96 Sharma, Dudus, Nielsen, Clausen, Yankaskas, Hollingsworth, Engelhardt (b0320) 1998; 19 Huang, Boda, Vernaz, Ferreira, Wiszniewski, Constant (b0480) 2017; 118 Cervena, Vrbova, Rossnerova, Topinka, Rossner (b0520) 2019; 47 Kinnula, Yankaskas, Chang, Virtanen, Linnala, Kang, Crapo (b0690) 1994; 11 Tamo, Hibaoui, Kallol, Alves, Albrecht, Hostettler, Feki, Rougier, Abriel, Knudsen, Gazdhar, Geiser (b0580) 2018; 315 Kumar, Dailey, Swedrowska, Siow, Mann, Vizcay-Barrena, Arno, Mudway, Forbes (b0840) 2016; 590 Emami (b0025) 2006; 9 Sakamoto, Matsumaru, Yamamura, Uchida, Tachikawa, Ohtsuki, Terasaki (b0200) 2013; 102 Ji, Hedelin, Malmlof, Kessler, Seisenbaeva, Gerde, Palmberg (b0425) 2017; 12 Schmid, Stoeger (b0055) 2016; 99 Amoako-Tuffour, Yeung, Agu (b0780) 2009; 59 A. Kuehn, S. Kletting, C. de Souza Carvalho-Wodarz, U. Repnik, G. Griffiths, U. Fischer, E. Meese, H. Huwer, D. Wirth, T. May, N. Schneider-Daum, C.M. Lehr, Human alveolar epithelial cells expressing tight junctions to model the air-blood barrier, ALTEX. 33 (2016) 251-60. Yoon, Kim, Kim, Lee, Park (b0235) 2000; 109 Schamberger, Mise, Jia, Genoyer, Yildirim, Meiners, Eickelberg (b0330) 2014; 50 M.D. Perloff, L.L.V. Moltke, D.J. Greenblatt, Fexofenadine Transport in Caco-2 Cells: Inhibition with Verapamil and Ritonavir, J Clin Pharmacol. 42 (2002) 1269-74. Hilfer, Schneck, Brown (b0030) 1986; 10 Van Haute, De Block, Liebaers, Sermon, De Rycke (b0575) 2009; 10 A.L. Mescher, The Respiratory System, in: M. Weitz & Kearns, B.s (Eds.), Junqueira's Basic Histology: Text and Atlas. McGraw-Hill Education LANGE, 2013, pp. 343-363. Gostner, Zeisler, Alam, Gruber, Fuchs, Becker, Neubert, Kleinhappl, Martini, Uberall (b0845) 2016; 6 Furubayashi, Inoue, Nishiyama, Tanaka, Yutani, Kimura, Katsumi, Yamamoto, Sakane (b0490) 2020; 12 Teijeiro-Osorio, Remuñán-López, Alonso (b0790) 2009; 10 Perrin, Kenney, Rosenbaum (b0460) 2020; 383 Wengst, Reichl (b0600) 2010; 74 Leung, Wadsworth, Yang, Dorscheid (b0345) 2020; 318 Qian, Travanty, Oko, Edeen, Berglund, Wang, Ito, Holmes, Mason (b0450) 2013; 48 Ladel, Schlossbauer, Flamm, Luksch, Mizaikoff, Schindowski (b0605) 2019; 11 Reichl, Becker (b0620) 2012; 64 Ehrhardt, Kneuer, Laue, Schaefer, Kim, Lehr (b0670) 2003; 20 Ortiz-Prado, Dunn, Vasconez, Castillo, Viscor (b0835) 2019; 9 Pillai, Sankoorikal, Johnson, Seneviratne, Zurko, Brown, Hathout, Rose (b0340) 2014; 50 Zamprogno, Wuthrich, Achenbach, Thoma, Stucki, Hobi, Schneider-Daum, Lehr, Huwer, Geiser, Schmid, Guenat (b0465) 2021; 4 Crystal, Randell, Engelhardt, Voynow, Sunday (b0130) 2008; 5 Pozzoli, Ong, Morgan, Sukkar, Traini, Young, Sonvico (b0630) 2016; 107 Cho, Ku, Termsarasab, Yoon, Chung, Moon, Kim (b0290) 2012; 423 Lee, Yoo, Lin, Kim, Kim, Choi, Park, Lee, Roh (b0260) 2005; 12 Jing, Park, Peters, Thorne (b0415) 2015; 29 Torky, Stehfest, Viehweger, Taege, Foth (b0400) 2005; 207 Huang, Wiszniewski, Constant, Roggen (b0500) 2013; 27 Grainger, Greenwell, Martin, Forbes (b0800) 2009; 71 Zawadzka, Jelen, Pietrzak, Zebrowska-Nawrocka, Michalska, Szmajda-Krygier, Mirowski, Lochowski, Kozak, Balcerczak (b0730) 2020; 10 Endter, Becker, Daum, Huwer, Lehr, Gumbleton, Ehrhardt (b0155) 2006; 328 Gonçalves, Silva, Gouveia, Bicker, Falcao, Alves, Fortuna (b0650) 2021; 593 Hermanns, Unger, Kehe, Peters, Kirkpatrick (b0890) 2004; 84 Vitorino, Silva, Gouveia, Bicker, Falcao, Fortuna (b0005) 2020; 153 G. Camenisch, J. Alsenz, H.V.D. Waterbeemd, G. Folkers, Estimation of permeability by passive diffusion through Caco-2 cell monolayers using the drugs’ lipophilicity and molecular weight, Eur. J. Pharm. Sci. 6 (1998) 313–319. Bur, Huwer, Muys, Lehr (b0775) 2010; 23 Zscheppang, Berg, Hedtrich, Verheyen, Wagner, Suttorp, Hippenstiel, Hocke (b0470) 2018; 13 Liang, Pan, Vllasaliu, Lam (b0010) 2020; 12 Barosova, Maione, Septiadi, Sharma, Haeni, Balog, O'Connell, Jackson, Brown, Clippinger, Hayden, Petri-Fink, Stone, Rothen-Rutishauser (b0565) 2020; 14 Cho, Balakrishnan, Park, Song, Hong, Jang, Kim, Chung, Shim, Kim (b0285) 2011; 100 Balogh Sivars, Sivars, Hornberg, Zhang, Branden, Bonfante, Huang, Constant, Robinson, Betts, Aberg (b0495) 2018; 162 Cingolani, Alqahtani, Sadler, Prime, Stolnik, Bosquillon (b0760) 2019; 141 Haghi, Traini, Bebawy, Young (b0390) 2012; 9 Tsoutsoulopoulos, Mohle, Aufderheide, Schmidt, Thiermann, Steinritz (b0865) 2016; 244 Oliveira, Fortuna, Alves, Falcão (b0125) 2016; 17 Schamberger, Staab-Weijnitz, Mise-Racek, Eickelberg (b0335) 2015; 5 Cho, Balakrishnan, Shim, Chung, Shim, Kim (b0275) 2010; 400 Grainger, Greenwell, Lockley, Martin, Forbes (b0740) 2006; 23 Dolberg, Reichl (b0145) 2016; 508 Stewart, Torr, Mohd Jamili, Bosquillon, Sayers (b0350) 2012, 2012 Lim (b0050) 2015; 31 Bai, Yang, Abbruscato, Ahsan (b0595) 2008; 97 C.M. Mercier, S. Hodin, Z. He, N. Perek, X. Delavenne, Pharmacological Characterization of the RPMI 2650 Model as a Relevant Tool for Assessing the Permeability of Intranasal Drugs, Mol. Pharmaceutics. 15 (2018) 2246−2256. Wagner, Wheeler, Ribbeck (b0090) 2018; 34 Lechapt-Zalcman, Hurbain, Lacave, Commo, Urban, Antoine, Milleron, Bernaudin (b0150) 1997; 10 Wong, Vogel, Kokosinski, Matsumura (b0875) 2010; 42 Comer, Elborn, Ennis (b0230) 2012; 7 Luyts, Napierska, Dinsdale, Klein, Serchi, Hoet (b0675) 2015; 29 Bourganis, Kammona, Alexopoulos, Kiparissides (b0075) 2018; 128 Huh, Cho, Yoon, Choi, Kim, Oh, Chung, Shim, Kim (b0280) 2010; 40 Signer, Jonsdottir, Albrich, Strasser, Zust, Ryter, Ackermann-Gaumann, Lenz, Siegrist, Suter, Schoop, Engler (b0525) 2020; 17 Zavala, O'Brien, Lichtveld, Sexton, Rusyn, Jaspers, Vizuete (b0545) 2016; 28 Savla, Waters (b0660) 1998; 150 Bleich, Shan, Himmerkus (b0705) 2012; 1258 De Servi, Ranzini, Pique (b0510) 2017; 13 Zhang, Reenstra, Chidekel (b0765) 2001; 25 Hein, Bur, Kolb, Muellinger, Schaefer, Lehr (b0805) 2010; 38 Tong, Zhou, Perelman, Kolosov (b0665) 2014; 34 Endter, Francombe, Ehrhardt, Gumbleton (b0165) 2009; 61 Tong, Gu (b0265) 2020; 20 Pizzorno, Padey, Julien, Trouillet-Assant, Traversier, Errazuriz-Cerda, Fouret, Dubois, Gaymard, Lescure, Duliere, Brun, Constant, Poissy, Lina, Yazdanpanah, Terrier, Rosa-Calatrava (b0535) 2020; 1 Rohm, Carle, Maigler, Flamm, Kramer, Mavoungou, Schmid, Schindowski (b0645) 2017; 532 Kreft, Jerman, Lasič, Rižner, Hevir-Kene, Peternel, Kristan (b0610) 2015; 32 Reus, Maas, Jansen, Constant, Staal, van Triel, Kuper (b0505) 2014; 28 Winton, Wan, Cannell, Gruenert, Thompson, Garrod, Stewart, Robinson (b0815) 1998; 28 Luengen, Kniebs, Buhl, Cornelissen, Schmitz-Rode, Jockenhoevel, Thiebes (b0250) 2020; 10 Rhee, Min, Lee, Kwon, Lee, Yi, Park (b0255) 2001; 110 Blank, Rothen-Rutishauser, Schurch, Gehr (b0830) 2006; 19 Ahmad, Ahmad, Neeves, Hendry-Hofer, Loader, White, Veress (b0060) 2014 Sakamoto, Matsumaru, Yamamura, Suzuki, Uchida, Tachikawa, Terasaki (b0195) 2015; 104 Rayner, Makena, Prasad, Cormet-Boyaka (b0355) 2019; 9 Kao, Huang, Chen, Thai, Wachi, Kim, Tam, Wu (b0435) 2005; 175 Gonçalves, Matias, Poejo, Serra, Duarte (b0625) 2016; 515 Giunchedi, Gavini, Bonferoni (b0100) 2020; 12 Ren, Birch, Suresh (b0870) 2016; 11 Kim, Lewis, Nadel (b0880) 2011; 186 Lochhead, Thorne (b0080) 2012; 64 Brower, Carney, Oie, Gazdar, Minna (b0895) 1986; 46 Ghio, Dailey, Soukup, Stonehuerner, Richards, Devlin (b0040) 2013; 10 Ghaedi, Mendez, Bove, Sivarapatna, Raredon, Niklason (b0585) 2014; 35 Unwalla, Horvath, Roth, Conner, Salathe (b0395) 2012; 46 Metz, Knoth, Gross, Lehr, Stabler, Bock, Hittinger (b0515) 2018; 10 Noah, Yankaskas, Carson, Gambling, Cazares, McKinnon, Devlin (b0700) 1995; 31 Weber, Hebestreit, Wilms, Conroy, Rodrigo (b0715) 2013; 27 Lenz, Karg, Brendel, Hinze-Heyn, Maier, Eickelberg, Stoeger, Schmid (b0855) 2013; 2013 Su, Bao, Zhang, Smith, Hong, Ding (b0110) 2000; 60 Evans, Koo (b0915) 2009; 121 Lambrecht, Hammad, Fahy (b0220) 2019; 50 Mülhopt, Paur, Diabaté, Krug (b0405) 2008 Hamilton, Backstrom, Yazdanian, Audus (b0725) 2001; 90 Leibrock, Jungnickel, Tentschert, Katz, Toman, Petersen, Bierkandt, Singh, Laux, Luch (b0065) 2020; 10 K.M. Abo, L. Ma, T. Matte, J. Huang, K.D. Alysandratos, R.B. Werder, A. Mithal, M.L. Beermann, J. Lindstrom-Vautrin, G. Mostoslavsky, L. Ikonomou, D.N. Kotton, F. Hawkins, A. Wilson, C. Villacorta-Martin, Human iPSC-derived alveolar and airway epithelial cells can be cultured at air-liquid interface and express SARS-CoV-2 host factors, bioRxiv. PREPRINT (2020). Cooper, Abdullatif, Burnett, Kempsell, Conforti, Tolley, Collins, Davies (b0825) 2016; 11 Dwivedi, Upadhyay, Johanson, Ernstgård, Palmberg (b0360) 2018; 46 Hubatsch, Ragnarsson, Artursson (b0190) 2007; 2 Prytherch, Job, Marshall, Oreffo, Foster, BeruBe (b0225) 2011; 11 Rotoli, Barilli, Visigalli, Ferrari, Frati, Lagrasta, Lascia, Riccardi, Puccini, Dall'Asta (b0550) 2020; 21 Mukherjee, Pritchard, Bosquillon (b0735) 2012; 426 Herzog, Loza, Balog, Clift, Epple, Gehr, Petri-Fink, Rothen-Rutishauser (b0860) 2014; 5 Stentebjerg-Andersen, Notlevsen, Brodin, Nielsen (b0745) 2011; 78 Justus, Leffler, Ruiz-Echevarria, Yang (b0240) 2014 Dhamankar, Assem, Donovan (b0120) 2015; 27 Avanzato, Matson, Seifert, Pryce, Williamson, Anzick, Barbian, Judson, Fischer, Martens, Bowden, de Wit, Riedo, Munster (b0570) 2020; 183 Gerovac, Valencia, Baumlin, Salathe, Conner, Fregien (b0035) 2014; 51 Knudsen, Ochs (b0140) 2018; 150 Florea, van der Sandt, Schrier, Kooiman, Deryckere, Boer, Junginger, Borchard (b0720) 2001; 134 Kim, Peters, O'Shaughnessy, Adamcakova-Dodd, Thorne (b0410) 2013; 27 Hasenberg, Stegemann-Koniszewski, Gunzer (b0135) 2013; 251 Park, Kim, Dai, Zhang (b0695) 2015; 287 Ramesh Babu, Chidekel, Utidjian, Shaffer (b0770) 2004; 319 K.A.F. O'brien, L.L. Smith, G.M. Cohen, Inability Of A Human Lung Tumour Cell Line (A549) To Detect Chemically Induced Organ-Specific Toxicity To The Lung, Toxic. 1 (1987) 85-90. J. Atsuta, S.A. Sterbinsky, J. Plitt, L.M. Schwiebert, Bruce S. Bochner, R.P. Schleimer, Phenotyping Kumar (10.1016/j.ejpb.2023.01.013_b0840) 2016; 590 Luengen (10.1016/j.ejpb.2023.01.013_b0250) 2020; 10 Unwalla (10.1016/j.ejpb.2023.01.013_b0395) 2012; 46 Foster (10.1016/j.ejpb.2023.01.013_b0810) 1998; 243 Torky (10.1016/j.ejpb.2023.01.013_b0400) 2005; 207 Pozzoli (10.1016/j.ejpb.2023.01.013_b0630) 2016; 107 Maisonnasse (10.1016/j.ejpb.2023.01.013_b0530) 2020; 585 Wong (10.1016/j.ejpb.2023.01.013_b0875) 2010; 42 Huang (10.1016/j.ejpb.2023.01.013_b0480) 2017; 118 10.1016/j.ejpb.2023.01.013_b0555 Grainger (10.1016/j.ejpb.2023.01.013_b0800) 2009; 71 Hasenberg (10.1016/j.ejpb.2023.01.013_b0135) 2013; 251 Justus (10.1016/j.ejpb.2023.01.013_b0240) 2014 Kim (10.1016/j.ejpb.2023.01.013_b0880) 2011; 186 Ramesh Babu (10.1016/j.ejpb.2023.01.013_b0770) 2004; 319 Park (10.1016/j.ejpb.2023.01.013_b0695) 2015; 287 Bourganis (10.1016/j.ejpb.2023.01.013_b0075) 2018; 128 Azzopardi (10.1016/j.ejpb.2023.01.013_b0900) 2015; 29 Zhang (10.1016/j.ejpb.2023.01.013_b0765) 2001; 25 Rotoli (10.1016/j.ejpb.2023.01.013_b0550) 2020; 21 Lim (10.1016/j.ejpb.2023.01.013_b0050) 2015; 31 Gerde (10.1016/j.ejpb.2023.01.013_b0420) 2004; 16 Huh (10.1016/j.ejpb.2023.01.013_b0280) 2010; 40 Ahmad (10.1016/j.ejpb.2023.01.013_b0060) 2014 Knudsen (10.1016/j.ejpb.2023.01.013_b0140) 2018; 150 10.1016/j.ejpb.2023.01.013_b0685 Cingolani (10.1016/j.ejpb.2023.01.013_b0760) 2019; 141 Metz (10.1016/j.ejpb.2023.01.013_b0515) 2018; 10 Pizzorno (10.1016/j.ejpb.2023.01.013_b0535) 2020; 1 Zawadzka (10.1016/j.ejpb.2023.01.013_b0730) 2020; 10 10.1016/j.ejpb.2023.01.013_b0205 Schamberger (10.1016/j.ejpb.2023.01.013_b0330) 2014; 50 Yoon (10.1016/j.ejpb.2023.01.013_b0235) 2000; 109 Rhee (10.1016/j.ejpb.2023.01.013_b0255) 2001; 110 Emami (10.1016/j.ejpb.2023.01.013_b0025) 2006; 9 Van Goor (10.1016/j.ejpb.2023.01.013_b0310) 2006; 290 Savla (10.1016/j.ejpb.2023.01.013_b0660) 1998; 150 Jeong (10.1016/j.ejpb.2023.01.013_b0755) 2019; 98 Su (10.1016/j.ejpb.2023.01.013_b0110) 2000; 60 Huang (10.1016/j.ejpb.2023.01.013_b0500) 2013; 27 Endter (10.1016/j.ejpb.2023.01.013_b0165) 2009; 61 Aufderheide (10.1016/j.ejpb.2023.01.013_b0185) 2000; 52 Lin (10.1016/j.ejpb.2023.01.013_b0295) 2007; 330 Gostner (10.1016/j.ejpb.2023.01.013_b0845) 2016; 6 Zavala (10.1016/j.ejpb.2023.01.013_b0545) 2016; 28 Lenz (10.1016/j.ejpb.2023.01.013_b0855) 2013; 2013 Schamberger (10.1016/j.ejpb.2023.01.013_b0335) 2015; 5 Willoughby (10.1016/j.ejpb.2023.01.013_b0540) 2015; 1 Kinnula (10.1016/j.ejpb.2023.01.013_b0690) 1994; 11 Gonçalves (10.1016/j.ejpb.2023.01.013_b0625) 2016; 515 Hermanns (10.1016/j.ejpb.2023.01.013_b0890) 2004; 84 Kao (10.1016/j.ejpb.2023.01.013_b0435) 2005; 175 Grainger (10.1016/j.ejpb.2023.01.013_b0740) 2006; 23 Johnson (10.1016/j.ejpb.2023.01.013_b0325) 1993; 264 10.1016/j.ejpb.2023.01.013_b0375 Irvine (10.1016/j.ejpb.2023.01.013_b0175) 1999; 88 Al-Ghabeish (10.1016/j.ejpb.2023.01.013_b0160) 2015; 12 Tamo (10.1016/j.ejpb.2023.01.013_b0580) 2018; 315 Sarkar (10.1016/j.ejpb.2023.01.013_b0115) 1992; 9 Oliveira (10.1016/j.ejpb.2023.01.013_b0125) 2016; 17 Cho (10.1016/j.ejpb.2023.01.013_b0275) 2010; 400 Van Haute (10.1016/j.ejpb.2023.01.013_b0575) 2009; 10 Ghio (10.1016/j.ejpb.2023.01.013_b0040) 2013; 10 Mercier (10.1016/j.ejpb.2023.01.013_b0475) 2019; 139 Endter (10.1016/j.ejpb.2023.01.013_b0155) 2006; 328 Herzog (10.1016/j.ejpb.2023.01.013_b0860) 2014; 5 Qian (10.1016/j.ejpb.2023.01.013_b0450) 2013; 48 Sakamoto (10.1016/j.ejpb.2023.01.013_b0200) 2013; 102 Lee (10.1016/j.ejpb.2023.01.013_b0260) 2005; 12 Kürti (10.1016/j.ejpb.2023.01.013_b0615) 2013; 65 Bleich (10.1016/j.ejpb.2023.01.013_b0705) 2012; 1258 Weber (10.1016/j.ejpb.2023.01.013_b0715) 2013; 27 Witschi (10.1016/j.ejpb.2023.01.013_b0785) 1999; 16 Vitorino (10.1016/j.ejpb.2023.01.013_b0005) 2020; 153 10.1016/j.ejpb.2023.01.013_b0385 Avanzato (10.1016/j.ejpb.2023.01.013_b0570) 2020; 183 10.1016/j.ejpb.2023.01.013_b0820 Leung (10.1016/j.ejpb.2023.01.013_b0345) 2020; 318 Cho (10.1016/j.ejpb.2023.01.013_b0285) 2011; 100 Balogh Sivars (10.1016/j.ejpb.2023.01.013_b0495) 2018; 162 Salomon (10.1016/j.ejpb.2023.01.013_b0885) 2014; 11 Zhang (10.1016/j.ejpb.2023.01.013_b0105) 2005; 33 Cooper (10.1016/j.ejpb.2023.01.013_b0825) 2016; 11 Hubatsch (10.1016/j.ejpb.2023.01.013_b0190) 2007; 2 Hilfer (10.1016/j.ejpb.2023.01.013_b0030) 1986; 10 Awatade (10.1016/j.ejpb.2023.01.013_b0305) 2015; 2 Stewart (10.1016/j.ejpb.2023.01.013_b0350) 2012 Gerovac (10.1016/j.ejpb.2023.01.013_b0035) 2014; 51 Blank (10.1016/j.ejpb.2023.01.013_b0830) 2006; 19 Haghi (10.1016/j.ejpb.2023.01.013_b0390) 2012; 9 10.1016/j.ejpb.2023.01.013_b0635 10.1016/j.ejpb.2023.01.013_b0910 Lin (10.1016/j.ejpb.2023.01.013_b0380) 2007; 96 Wadell (10.1016/j.ejpb.2023.01.013_b0015) 2003; 18 Yamaya (10.1016/j.ejpb.2023.01.013_b0315) 1992; 262 Gonçalves (10.1016/j.ejpb.2023.01.013_b0650) 2021; 593 Gizurarson (10.1016/j.ejpb.2023.01.013_b0095) 2015; 38 Courcot (10.1016/j.ejpb.2023.01.013_b0710) 2012; 40 Perrin (10.1016/j.ejpb.2023.01.013_b0460) 2020; 383 Lambrecht (10.1016/j.ejpb.2023.01.013_b0220) 2019; 50 Comer (10.1016/j.ejpb.2023.01.013_b0230) 2012; 7 10.1016/j.ejpb.2023.01.013_b0085 Ji (10.1016/j.ejpb.2023.01.013_b0425) 2017; 12 Bai (10.1016/j.ejpb.2023.01.013_b0595) 2008; 97 Cervena (10.1016/j.ejpb.2023.01.013_b0520) 2019; 47 Hein (10.1016/j.ejpb.2023.01.013_b0805) 2010; 38 Limbach (10.1016/j.ejpb.2023.01.013_b0045) 2005; 39 McGovern (10.1016/j.ejpb.2023.01.013_b0370) 2010; 299 Mukherjee (10.1016/j.ejpb.2023.01.013_b0735) 2012; 426 Klein (10.1016/j.ejpb.2023.01.013_b0180) 2013; 10 Teijeiro-Osorio (10.1016/j.ejpb.2023.01.013_b0790) 2009; 10 Schmid (10.1016/j.ejpb.2023.01.013_b0055) 2016; 99 Dhamankar (10.1016/j.ejpb.2023.01.013_b0120) 2015; 27 Manford (10.1016/j.ejpb.2023.01.013_b0680) 2005; 26 Ortiz-Prado (10.1016/j.ejpb.2023.01.013_b0835) 2019; 9 Ladel (10.1016/j.ejpb.2023.01.013_b0605) 2019; 11 Cho (10.1016/j.ejpb.2023.01.013_b0300) 2011; 63 10.1016/j.ejpb.2023.01.013_b0485 Acosta (10.1016/j.ejpb.2023.01.013_b0560) 2020; 23 Pillai (10.1016/j.ejpb.2023.01.013_b0340) 2014; 50 Wagner (10.1016/j.ejpb.2023.01.013_b0090) 2018; 34 Brower (10.1016/j.ejpb.2023.01.013_b0895) 1986; 46 Crystal (10.1016/j.ejpb.2023.01.013_b0130) 2008; 5 Bur (10.1016/j.ejpb.2023.01.013_b0775) 2010; 23 Chung (10.1016/j.ejpb.2023.01.013_b0215) 2001; 18 Ghaedi (10.1016/j.ejpb.2023.01.013_b0585) 2014; 35 Furubayashi (10.1016/j.ejpb.2023.01.013_b0490) 2020; 12 Tsoutsoulopoulos (10.1016/j.ejpb.2023.01.013_b0865) 2016; 244 Thai (10.1016/j.ejpb.2023.01.013_b0430) 2005; 33 Tong (10.1016/j.ejpb.2023.01.013_b0665) 2014; 34 Kreft (10.1016/j.ejpb.2023.01.013_b0610) 2015; 32 Reus (10.1016/j.ejpb.2023.01.013_b0505) 2014; 28 Wang (10.1016/j.ejpb.2023.01.013_b0440) 2011; 44 Hamilton (10.1016/j.ejpb.2023.01.013_b0725) 2001; 90 Dolberg (10.1016/j.ejpb.2023.01.013_b0145) 2016; 508 Jing (10.1016/j.ejpb.2023.01.013_b0415) 2015; 29 Reichl (10.1016/j.ejpb.2023.01.013_b0620) 2012; 64 Zscheppang (10.1016/j.ejpb.2023.01.013_b0470) 2018; 13 Noah (10.1016/j.ejpb.2023.01.013_b0700) 1995; 31 Evans (10.1016/j.ejpb.2023.01.013_b0915) 2009; 121 Christensen (10.1016/j.ejpb.2023.01.013_b0795) 2010; 390 10.1016/j.ejpb.2023.01.013_b0455 Giunchedi (10.1016/j.ejpb.2023.01.013_b0100) 2020; 12 De Servi (10.1016/j.ejpb.2023.01.013_b0510) 2017; 13 Dolberg (10.1016/j.ejpb.2023.01.013_b0170) 2017; 14 Barosova (10.1016/j.ejpb.2023.01.013_b0565) 2020; 14 Rohm (10.1016/j.ejpb.2023.01.013_b0645) 2017; 532 Yoo (10.1016/j.ejpb.2023.01.013_b0245) 2003; 20 Lochhead (10.1016/j.ejpb.2023.01.013_b0080) 2012; 64 Lechapt-Zalcman (10.1016/j.ejpb.2023.01.013_b0150) 1997; 10 Kato (10.1016/j.ejpb.2023.01.013_b0445) 2013; 2 Mülhopt (10.1016/j.ejpb.2023.01.013_b0405) 2008 Tong (10.1016/j.ejpb.2023.01.013_b0265) 2020; 20 Zhou (10.1016/j.ejpb.2023.01.013_b0270) 2009; 21 Konig (10.1016/j.ejpb.2023.01.013_b0210) 2015; 11 Sharma (10.1016/j.ejpb.2023.01.013_b0320) 1998; 19 Amoako-Tuffour (10.1016/j.ejpb.2023.01.013_b0780) 2009; 59 10.1016/j.ejpb.2023.01.013_b0905 Kim (10.1016/j.ejpb.2023.01.013_b0410) 2013; 27 Sakamoto (10.1016/j.ejpb.2023.01.013_b0195) 2015; 104 Sun (10.1016/j.ejpb.2023.01.013_b0365) 2014; 229 Rayner (10.1016/j.ejpb.2023.01.013_b0355) 2019; 9 Leibrock (10.1016/j.ejpb.2023.01.013_b0065) 2020; 10 Lenz (10.1016/j.ejpb.2023.01.013_b0850) 2009; 6 Luyts (10.1016/j.ejpb.2023.01.013_b0675) 2015; 29 Florea (10.1016/j.ejpb.2023.01.013_b0720) 2001; 134 Ren (10.1016/j.ejpb.2023.01.013_b0870) 2016; 11 Prytherch (10.1016/j.ejpb.2023.01.013_b0225) 2011; 11 10.1016/j.ejpb.2023.01.013_b0590 Cozens (10.1016/j.ejpb.2023.01.013_b0655) 1994; 10 Winton (10.1016/j.ejpb.2023.01.013_b0815) 1998; 28 Clippinger (10.1016/j.ejpb.2023.01.013_b0020) 2016; 90 Kim (10.1016/j.ejpb.2023.01.013_b0640) 2018; 8 Zamprogno (10.1016/j.ejpb.2023.01.013_b0465) 2021; 4 Wengst (10.1016/j.ejpb.2023.01.013_b0600) 2010; 74 Dwivedi (10.1016/j.ejpb.2023.01.013_b0360) 2018; 46 Signer (10.1016/j.ejpb.2023.01.013_b0525) 2020; 17 Lacroix (10.1016/j.ejpb.2023.01.013_b0070) 2018; 4 Cho (10.1016/j.ejpb.2023.01.013_b0290) 2012; 423 Stentebjerg-Andersen (10.1016/j.ejpb.2023.01.013_b0745) 2011; 78 Meindl (10.1016/j.ejpb.2023.01.013_b0750) 2015; 10 Liang (10.1016/j.ejpb.2023.01.013_b0010) 2020; 12 Ehrhardt (10.1016/j.ejpb.2023.01.013_b0670) 2003; 20 |
| References_xml | – volume: 183 start-page: 1901 year: 2020 end-page: 1912 ident: b0570 article-title: Case Study: Prolonged Infectious SARS-CoV-2 Shedding from an Asymptomatic Immunocompromised Individual with Cancer publication-title: Cell – volume: 9 start-page: 1 year: 1992 end-page: 9 ident: b0115 article-title: Drug Metabolism in the Nasal Mucosa publication-title: Pharm. Res. – volume: 11 start-page: 995 year: 2014 end-page: 1006 ident: b0885 article-title: The cell line NCl-H441 is a useful in vitro model for transport studies of human distal lung epithelial barrier publication-title: Mol. Pharm. – volume: 264 start-page: L560 year: 1993 end-page: L565 ident: b0325 article-title: Enhanced Na publication-title: American Physiol. Soc. – volume: 32 start-page: 665 year: 2015 end-page: 679 ident: b0610 article-title: The Characterization of the Human Nasal Epithelial Cell Line RPMI 2650 Under Different Culture Conditions and Their Optimization for an Appropriate in vitro Nasal Model publication-title: Pharm. Res. – volume: 27 start-page: 1987 year: 2013 end-page: 1991 ident: b0715 article-title: Comet assay and air-liquid interface exposure system: a new combination to evaluate genotoxic effects of cigarette whole smoke in human lung cell lines publication-title: Toxicol. In Vitro – volume: 508 start-page: 22 year: 2016 end-page: 33 ident: b0145 article-title: Expression of P-glycoprotein in excised human nasal mucosa and optimized models of RPMI 2650 cells publication-title: Int. J. Pharm. – volume: 593 year: 2021 ident: b0650 article-title: A combo-strategy to improve brain delivery of antiepileptic drugs: Focus on BCRP and intranasal administration publication-title: Int. J. Pharm. – reference: R. Visigalli, B.M. Rotoli, F. Ferrari, M. Di Lascia, B. Riccardi, P. Puccini, V. Dall’Asta, A. Barilli, Expression and Function of ABC Transporters in Human Alveolar Epithelial Cells, Biomolecules. 12 (2022) 1260. – volume: 12 start-page: 2742 year: 2015 end-page: 2754 ident: b0160 article-title: Microarray Determination of the Expression of Drug Transporters in Humans and Animal Species Used for the Investigation of Nasal Absorption publication-title: Mol. Pharm. – volume: 153 start-page: 106 year: 2020 end-page: 120 ident: b0005 article-title: QbD-driven development of intranasal lipid nanoparticles for depression treatment publication-title: Eur. J. Pharm. Biopharm. – volume: 13 year: 2018 ident: b0470 article-title: Human Pulmonary 3D Models For Translational Research publication-title: Biotechnol. J. – volume: 29 start-page: 502 year: 2015 end-page: 511 ident: b0415 article-title: Toxicity of copper oxide nanoparticles in lung epithelial cells exposed at the air-liquid interface compared with in vivo assessment publication-title: Toxicol. In Vitro – volume: 84 start-page: 736 year: 2004 end-page: 752 ident: b0890 article-title: Lung epithelial cell lines in coculture with human pulmonary microvascular endothelial cells: development of an alveolo-capillary barrier in vitro publication-title: Lab. Invest. – volume: 426 start-page: 7 year: 2012 end-page: 14 ident: b0735 article-title: Evaluation of air-interfaced Calu-3 cell layers for investigation of inhaled drug interactions with organic cation transporters in vitro publication-title: Int. J. Pharm. – volume: 27 start-page: 1151 year: 2013 end-page: 1156 ident: b0500 article-title: Potential of in vitro reconstituted 3D human airway epithelia (MucilAir) to assess respiratory sensitizers publication-title: Toxicol. In Vitro – volume: 5 start-page: 1357 year: 2014 end-page: 1370 ident: b0860 article-title: Mimicking exposures to acute and lifetime concentrations of inhaled silver nanoparticles by two different in vitro approaches publication-title: Beilstein J. Nanotechnol. – volume: 29 start-page: 234 year: 2015 end-page: 241 ident: b0675 article-title: A coculture model of the lung-blood barrier: the role of activated phagocytic cells publication-title: Toxicol. In Vitro – volume: 299 start-page: L808 year: 2010 end-page: L815 ident: b0370 article-title: LTD4 induces HB-EGF-dependent CXCL8 release through EGFR activation in human bronchial epithelial cells, American Journal of Physiology-Lung Cellular and Molecular publication-title: Physiology – year: 2014 ident: b0060 article-title: In vitro cell culture model for toxic inhaled chemical testing publication-title: J. Vis. Exp. – volume: 46 start-page: 551 year: 2012 end-page: 558 ident: b0395 article-title: Albuterol modulates its own transepithelial flux via changes in paracellular permeability publication-title: Am. J. Respir. Cell Mol. Biol. – volume: 262 start-page: L713 year: 1992 end-page: L724 ident: b0315 article-title: Differentiated structure and function of cultures from human tracheal epithelium publication-title: Am. J. Phys. Anthropol. – reference: C.M. Mercier, S. Hodin, Z. He, N. Perek, X. Delavenne, Pharmacological Characterization of the RPMI 2650 Model as a Relevant Tool for Assessing the Permeability of Intranasal Drugs, Mol. Pharmaceutics. 15 (2018) 2246−2256. – volume: 21 year: 2020 ident: b0550 article-title: Characterization of ABC Transporters in EpiAirway, a Cellular Model of Normal Human Bronchial Epithelium publication-title: Int. J. Mol. Sci. – reference: M.D. Perloff, L.L.V. Moltke, D.J. Greenblatt, Fexofenadine Transport in Caco-2 Cells: Inhibition with Verapamil and Ritonavir, J Clin Pharmacol. 42 (2002) 1269-74. – volume: 12 year: 2020 ident: b0100 article-title: Nose-to-Brain Delivery publication-title: Pharmaceutics. – volume: 74 start-page: 290 year: 2010 end-page: 297 ident: b0600 article-title: RPMI 2650 epithelial model and three-dimensional reconstructed human nasal mucosa as in vitro models for nasal permeation studies publication-title: Eur. J. Pharm. Biopharm. – reference: G. Camenisch, J. Alsenz, H.V.D. Waterbeemd, G. Folkers, Estimation of permeability by passive diffusion through Caco-2 cell monolayers using the drugs’ lipophilicity and molecular weight, Eur. J. Pharm. Sci. 6 (1998) 313–319. – reference: J. Atsuta, S.A. Sterbinsky, J. Plitt, L.M. Schwiebert, Bruce S. Bochner, R.P. Schleimer, Phenotyping and Cytokine Regulation of the BEAS-2B Human Bronchial Epithelial Cell: Demonstration of Inducible Expression of the Adhesion Molecules VCAM-1 and ICAM-1, Am. J. Respir. Cell Mol. Biol. (1997) 571–582. – volume: 128 start-page: 337 year: 2018 end-page: 362 ident: b0075 article-title: Recent advances in carrier mediated nose-to-brain delivery of pharmaceutics publication-title: Eur. J. Pharm. Biopharm. – volume: 150 start-page: 661 year: 2018 end-page: 676 ident: b0140 article-title: The micromechanics of lung alveoli: structure and function of surfactant and tissue components publication-title: Histochem. Cell Biol. – volume: 141 start-page: 210 year: 2019 end-page: 220 ident: b0760 article-title: In vitro investigation on the impact of airway mucus on drug dissolution and absorption at the air-epithelium interface in the lungs publication-title: Eur. J. Pharm. Biopharm. – volume: 59 start-page: 395 year: 2009 end-page: 405 ident: b0780 article-title: Permeation of losartan across human respiratory epithelium: An in vitro study with Calu-3 cells publication-title: Acta Pharm. – volume: 50 start-page: 1040 year: 2014 end-page: 1052 ident: b0330 article-title: Cigarette Smoke-Induced Disruption of Bronchial Epithelial Tight Junctions Is Prevented by Transforming Growth Factor-β publication-title: Am. J. Respir. Cell Mol. Biol. – volume: 2 start-page: 147 year: 2015 end-page: 153 ident: b0305 article-title: Measurements of Functional Responses in Human Primary Lung Cells as a Basis for Personalized Therapy for Cystic Fibrosis publication-title: EBioMedicine – volume: 16 start-page: 45 year: 2004 end-page: 52 ident: b0420 article-title: A novel method to aerosolize powder for short inhalation exposures at high concentrations: isolated rat lungs exposed to respirable diesel soot publication-title: Inhal. Toxicol. – volume: 71 start-page: 318 year: 2009 end-page: 324 ident: b0800 article-title: The permeability of large molecular weight solutes following particle delivery to air-interfaced cells that model the respiratory mucosa publication-title: Eur. J. Pharm. Biopharm. – volume: 38 start-page: 285 year: 2010 end-page: 295 ident: b0805 article-title: The Pharmaceutical Aerosol Deposition Device On Cell Cultures (PADDOCC) In Vitro System: Design and Experimental Protocol publication-title: ATLA. – reference: M.J. Flens, G.J.R. Zaman, P.v.d. Valk, M.A. lzquierdo, A.B. Schroeijers, G.L. Scheffer, P.v.d. Groep, M.d. Haas, C.J.L.M. Meijer, R.J. Scheper, Tissue Distribution of the Multidrug Resistance Protein, Am J Pat. 148 (1996) 1237-1247. – reference: A. Mulay, B. Konda, G. Garcia, C. Yao, S. Beil, C. Sen, A. Purkayastha, J.K. Kolls, D.A. Pociask, P. Pessina, J. Sainz de Aja, C. Garcia-de-Alba, C.F. Kim, B. Gomperts, V. Arumugaswami, B.R. Stripp, SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery, bioRxiv. (2020). – volume: 52 start-page: 265 year: 2000 end-page: 270 ident: b0185 article-title: CULTEX — an alternative technique for cultivation and exposure of cells of the respiratory tract to airborne pollutants at the air/liquid interface publication-title: Exp. Toxicol. Pathol. – volume: 9 start-page: 31 year: 2006 end-page: 51 ident: b0025 article-title: In vitro - In vivo Correlation: From Theory to Applications publication-title: J. Pharm. Pharmaceut. Sci. – volume: 10 year: 2018 ident: b0515 article-title: Combining MucilAir and Vitrocell((R)) Powder Chamber for the In Vitro Evaluation of Nasal Ointments in the Context of Aerosolized Pollen publication-title: Pharmaceutics. – volume: 47 start-page: 9 year: 2019 end-page: 18 ident: b0520 article-title: Short-term and Long-term Exposure of the MucilAir Model to Polycyclic Aromatic Hydrocarbons publication-title: Altern. Lab. Anim. – volume: 26 start-page: 414 year: 2005 end-page: 420 ident: b0680 article-title: Drug permeability in 16HBE14o- airway cell layers correlates with absorption from the isolated perfused rat lung publication-title: Eur. J. Pharm. Sci. – volume: 50 start-page: 292 year: 2014 end-page: 300 ident: b0340 article-title: Directional secretomes reflect polarity-specific functions in an in vitro model of human bronchial epithelium publication-title: Am. J. Respir. Cell Mol. Biol. – volume: 390 start-page: 19 year: 2010 end-page: 24 ident: b0795 article-title: CAF01 liposomes as a mucosal vaccine adjuvant: In vitro and in vivo investigations publication-title: Int. J. Pharm. – volume: 4 start-page: 91 year: 2018 end-page: 106 ident: b0070 article-title: Air-Liquid Interface In Vitro Models for Respiratory Toxicology Research: Consensus Workshop and Recommendations, Applied publication-title: In Vitro Toxicology. – volume: 318 start-page: L1063 year: 2020 end-page: L1073 ident: b0345 article-title: Structural and functional variations in human bronchial epithelial cells cultured in air-liquid interface using different growth media publication-title: Am. J. Physiol. Lung Cell. Mol. Physiol. – volume: 1 year: 2020 ident: b0535 article-title: Characterization and Treatment of SARS-CoV-2 in Nasal and Bronchial Human Airway Epithelia publication-title: Cell Rep Med. – volume: 18 start-page: 47 year: 2003 end-page: 53 ident: b0015 article-title: P ermeability of porcine nasal mucosa correlated with human nasal absorption publication-title: Eur. J. Pharm. Sci. – volume: 50 start-page: 975 year: 2019 end-page: 991 ident: b0220 article-title: The Cytokines of Asthma publication-title: Immunity – volume: 121 start-page: 332 year: 2009 end-page: 348 ident: b0915 article-title: Airway mucus: the good, the bad, the sticky publication-title: Pharmacol. Ther. – volume: 20 start-page: 1690 year: 2003 end-page: 1696 ident: b0245 article-title: Serially Passaged Human Nasal Epithelial Cell Monolayer for publication-title: Pharm. Res. – volume: 12 start-page: 305 year: 2005 end-page: 311 ident: b0260 article-title: Air-liquid interface culture of serially passaged human nasal epithelial cell monolayer for in vitro drug transport studies publication-title: Drug Deliv. – volume: 17 start-page: 628 year: 2016 end-page: 647 ident: b0125 article-title: Drug-metabolizing Enzymes and Efflux Transporters in Nasal Epithelium: Influence on the Bioavailability of Intranasally Administered Drugs, Curr Drugs publication-title: Metabolism – volume: 23 start-page: 119 year: 2010 end-page: 127 ident: b0775 article-title: Drug Transport Across Pulmonary Epithelial Cell Monolayers: Effects of Particle Size, Apical Liquid Volume, and Deposition Technique publication-title: J. Aerosol Med. Pulm. Drug Deliv. – volume: 34 year: 2014 ident: b0665 article-title: Effect of epithelium ATP release on cyclic pressure-induced airway mucus secretion publication-title: Biosci. Rep. – volume: 28 start-page: 1273 year: 1998 end-page: 1285 ident: b0815 article-title: Cell lines of pulmonary and non-pulmonary origin as tools to study the effects of house dust mite proteinases on the regulation of epithelial permeability, Clinical and Experimental publication-title: Allergy – volume: 10 year: 2020 ident: b0065 article-title: Parametric Optimization of an Air-Liquid Interface System for Flow-Through Inhalation Exposure to Nanoparticles: Assessing Dosimetry and Intracellular Uptake of CeO2 Nanoparticles publication-title: Nanomaterials (Basel). – volume: 44 start-page: 692 year: 2011 end-page: 699 ident: b0440 article-title: Type I alveolar epithelial phenotype in primary culture publication-title: Am. J. Respir. Cell Mol. Biol. – volume: 31 start-page: 738 year: 1995 end-page: 740 ident: b0700 article-title: Tight Junctions and Mucin mRNA in BEAS-2B Cells publication-title: In Vitro Cell. Dev. Biol. – volume: 38 start-page: 497 year: 2015 end-page: 506 ident: b0095 article-title: The Effect of Cilia and the Mucociliary Clearance on Successful Drug Delivery publication-title: Biol. Pharm. Bull. – volume: 290 start-page: L1117 year: 2006 end-page: L1130 ident: b0310 article-title: Rescue of DeltaF508-CFTR trafficking and gating in human cystic fibrosis airway primary cultures by small molecules publication-title: Am. J. Physiol. Lung Cell. Mol. Physiol. – volume: 10 start-page: 6188 year: 2020 ident: b0730 article-title: The impact of ABCB1 gene polymorphism and its expression on non-small-cell lung cancer development, progression and therapy - preliminary report publication-title: Sci. Rep. – volume: 5 start-page: 772 year: 2008 end-page: 777 ident: b0130 article-title: Airway epithelial cells: current concepts and challenges publication-title: Proc. Am. Thorac. Soc. – volume: 28 start-page: 251 year: 2016 end-page: 259 ident: b0545 article-title: Assessment of biological responses of EpiAirway 3-D cell constructs versus A549 cells for determining toxicity of ambient air pollution publication-title: Inhal. Toxicol. – volume: 23 start-page: 1482 year: 2006 end-page: 1490 ident: b0740 article-title: Culture of Calu-3 cells at the air interface provides a representative model of the airway epithelial barrier publication-title: Pharm. Res. – volume: 21 start-page: 875 year: 2009 end-page: 881 ident: b0270 article-title: Increased nasal epithelial ciliary beat frequency associated with lifestyle tobacco smoke exposure publication-title: Inhal. Toxicol. – volume: 60 start-page: 5074 year: 2000 end-page: 5079 ident: b0110 article-title: Human Cytochrome P450 CYP2A13: Predominant Expression in the Respiratory Tract and Its High Efficiency Metabolic Activation of a Tobacco-specific Carcinogen, 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone publication-title: Cancer Res. – volume: 175 start-page: 6676 year: 2005 end-page: 6685 ident: b0435 article-title: Up-regulation of CC chemokine ligand 20 expression in human airway epithelium by IL-17 through a JAK-independent but MEK/NF-kappaB-dependent signaling pathway publication-title: J. Immunol. – volume: 33 start-page: 1423 year: 2005 end-page: 1428 ident: b0105 article-title: Expression of cytochrome p450 and other biotransformation genes in fetal and adult human nasal mucosa publication-title: Drug Metab. Dispos. – volume: 61 start-page: 583 year: 2009 end-page: 591 ident: b0165 article-title: RT-PCR analysis of ABC, SLC and SLCO drug transporters in human lung epithelial cell models publication-title: J. Pharm. Pharmacol. – volume: 162 start-page: 301 year: 2018 end-page: 308 ident: b0495 article-title: A 3D Human Airway Model Enables Prediction of Respiratory Toxicity of Inhaled Drugs In Vitro publication-title: Toxicol. Sci. – volume: 12 year: 2020 ident: b0490 article-title: Comparison of Various Cell Lines and Three-Dimensional Mucociliary Tissue Model Systems to Estimate Drug Permeability Using an In Vitro Transport Study to Predict Nasal Drug Absorption in Rats publication-title: Pharmaceutics. – volume: 20 start-page: 545 year: 2003 end-page: 551 ident: b0670 article-title: 16HBE14o- Human Bronchial Epithelial Cell Layers Express P-Glycoprotein, Lung Resistance-Related Protein, and Caveolin-1 publication-title: Pharm. Res. – volume: 8 start-page: 168 year: 2018 ident: b0640 article-title: Enhanced nasal drug delivery efficiency by increasing mechanical loading using hypergravity publication-title: Sci. Rep. – volume: 16 start-page: 382 year: 1999 end-page: 390 ident: b0785 article-title: In Vitro Evaluation of Microparticles and Polymer Gels for Use as Nasal Platforms for Protein Delivery publication-title: Pharm. Res. – volume: 585 start-page: 584 year: 2020 end-page: 587 ident: b0530 article-title: Hydroxychloroquine use against SARS-CoV-2 infection in non-human primates publication-title: Nature – volume: 134 start-page: 1555 year: 2001 end-page: 1563 ident: b0720 article-title: Evidence of P-glycoprotein mediated apical to basolateral transport of flunisolide in human broncho-tracheal epithelial cells (Calu-3) publication-title: Br. J. Pharmacol. – volume: 319 start-page: 1132 year: 2004 end-page: 1137 ident: b0770 article-title: Regulation of apical surface fluid and protein secretion in human airway epithelial cell line Calu-3 publication-title: Biochem. Biophys. Res. Commun. – volume: 99 start-page: 133 year: 2016 end-page: 143 ident: b0055 article-title: Surface area is the biologically most effective dose metric for acute nanoparticle toxicity in the lung publication-title: J. Aerosol Sci – volume: 107 start-page: 223 year: 2016 end-page: 233 ident: b0630 article-title: Application of RPMI 2650 nasal cell model to a 3D printed apparatus for the testing of drug deposition and permeation of nasal products publication-title: Eur. J. Pharm. Biopharm. – volume: 9 start-page: 1717 year: 2012 end-page: 1726 ident: b0390 article-title: Deposition, diffusion and transport mechanism of dry powder microparticulate salbutamol, at the respiratory epithelia publication-title: Mol. Pharm. – volume: 10 start-page: 243 year: 2009 end-page: 249 ident: b0790 article-title: New Generation of Hybrid Poly/Oligosaccharide Nanoparticles as Carriers for the Nasal Delivery of Macromolecules publication-title: Biomacromolecules – reference: K.A.F. O'brien, L.L. Smith, G.M. Cohen, Inability Of A Human Lung Tumour Cell Line (A549) To Detect Chemically Induced Organ-Specific Toxicity To The Lung, Toxic. 1 (1987) 85-90. – volume: 11 start-page: 26 year: 2015 ident: b0210 article-title: Cytokine profiles in nasal fluid of patients with seasonal or persistent allergic rhinitis, Allergy Asthma publication-title: Clin. Immunol. – volume: 186 start-page: 3392 year: 2011 end-page: 3400 ident: b0880 article-title: CCL20/CCR6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial (NCI-H292) cells publication-title: J. Immunol. – volume: 11 year: 2019 ident: b0605 article-title: Improved In Vitro Model for Intranasal Mucosal Drug Delivery: Primary Olfactory and Respiratory Epithelial Cells Compared with the Permanent Nasal Cell Line RPMI 2650 publication-title: Pharmaceutics. – volume: 64 start-page: 614 year: 2012 end-page: 628 ident: b0080 article-title: Intranasal delivery of biologics to the central nervous system publication-title: Adv. Drug Deliv. Rev. – start-page: 943 year: 2012, 2012, end-page: 982 ident: b0350 article-title: Evaluation of differentiated human bronchial epithelial cell culture systems for asthma research publication-title: J Allergy (Cairo) – volume: 9 start-page: 1 year: 2019 end-page: 14 ident: b0835 article-title: Partial pressure of oxygen in the human body: a general review publication-title: Am J Blood Res. – reference: S. Kletting, S. Barthold, U. Repnik, G. Griffiths, B. Loretz, N. Schneider-Daum, C. de Souza Carvalho-Wodarz, C.M. Lehr, Co-culture of human alveolar epithelial (hAELVi) and macrophage (THP-1) cell lines, ALTEX. 35 (2018) 211-222. – volume: 9 start-page: 500 year: 2019 ident: b0355 article-title: Optimization of Normal Human Bronchial Epithelial (NHBE) Cell 3D Cultures for in vitro Lung Model Studies publication-title: Sci. Rep. – volume: 104 start-page: 3029 year: 2015 end-page: 3038 ident: b0195 article-title: Drug Transporter Protein Quantification of Immortalized Human Lung Cell Lines Derived from Tracheobronchial Epithelial Cells (Calu-3 and BEAS2-B), Bronchiolar-Alveolar Cells (NCI-H292 and NCI-H441), and Alveolar Type II-like Cells (A549) by Liquid Chromatography-Tandem Mass Spectrometry publication-title: J. Pharm. Sci. – volume: 515 start-page: 1 year: 2016 end-page: 10 ident: b0625 article-title: Application of RPMI 2650 as a cell model to evaluate solid formulations for intranasal delivery of drugs publication-title: Int. J. Pharm. – volume: 78 start-page: 19 year: 2011 end-page: 26 ident: b0745 article-title: Calu-3 cells grown under AIC and LCC conditions: implications for dipeptide uptake and transepithelial transport of substances publication-title: Eur. J. Pharm. Biopharm. – volume: 6 start-page: 32 year: 2009 ident: b0850 article-title: A dose-controlled system for air-liquid interface cell exposure and application to zinc oxide nanoparticles publication-title: Part. Fibre Toxicol. – volume: 27 start-page: 767 year: 2015 end-page: 777 ident: b0120 article-title: Gene expression and immunochemical localization of major cytochrome P450 drug-metabolizing enzymes in bovine nasal olfactory and respiratory mucosa publication-title: Inhal. Toxicol. – volume: 11 start-page: 568 year: 1994 end-page: 576 ident: b0690 article-title: Primary and Immortalized (BEAS 2B) Human Bronchial Epithelial Cells Have Significant Antioxidative Capacity In Vitro publication-title: Am. J. Respir. Cell Mol. BioI. – volume: 39 start-page: 9370 year: 2005 end-page: 9376 ident: b0045 article-title: Oxide Nanoparticle Uptake in Human Lung Fibroblasts: Effects of Particle Size, Agglomeration, and Diffusion at Low Concentrations publication-title: Environ. Sci. Tech. – volume: 243 start-page: 359 year: 1998 end-page: 366 ident: b0810 article-title: Characterization of the A549 Cell Line as a Type II Pulmonary Epithelial Cell Model for Drug Metabolism publication-title: Exp. Cell Res. – volume: 110 start-page: 1011 year: 2001 end-page: 1016 ident: b0255 article-title: Ciliary beat frequency in cultured human nasal epithelial cells publication-title: Ann. Otol. Rhinol. Laryngol. – volume: 11 start-page: e0164438 year: 2016 ident: b0825 article-title: Long Term Culture of the A549 Cancer Cell Line Promotes Multilamellar Body Formation and Differentiation towards an Alveolar Type II Pneumocyte Phenotype publication-title: PLoS One – volume: 20 start-page: 63 year: 2020 ident: b0265 article-title: Expression and Clinical Significance of Mucin Gene in Chronic Rhinosinusitis publication-title: Curr. Allergy Asthma Rep. – reference: A.L. Mescher, The Respiratory System, in: M. Weitz & Kearns, B.s (Eds.), Junqueira's Basic Histology: Text and Atlas. McGraw-Hill Education LANGE, 2013, pp. 343-363. – volume: 400 start-page: 59 year: 2010 end-page: 65 ident: b0275 article-title: Characterization and in vitro evaluation of freeze-dried microparticles composed of granisetron-cyclodextrin complex and carboxymethylcellulose for intranasal delivery publication-title: Int. J. Pharm. – volume: 229 start-page: 384 year: 2014 end-page: 392 ident: b0365 article-title: Acrolein induced both pulmonary inflammation and the death of lung epithelial cells publication-title: Toxicol. Lett. – volume: 10 start-page: e0135690 year: 2015 ident: b0750 article-title: Permeation of Therapeutic Drugs in Different Formulations across the Airway Epithelium In Vitro publication-title: PLoS One – volume: 14 start-page: 3941 year: 2020 end-page: 3956 ident: b0565 article-title: Use of EpiAlveolar Lung Model to Predict Fibrotic Potential of Multiwalled Carbon Nanotubes publication-title: ACS Nano – volume: 590 start-page: 258 year: 2016 end-page: 269 ident: b0840 article-title: Quantifying the magnitude of the oxygen artefact inherent in culturing airway cells under atmospheric oxygen versus physiological levels publication-title: FEBS Lett. – volume: 31 start-page: 181 year: 2015 end-page: 189 ident: b0050 article-title: Toxicity of Two Different Sized Lanthanum Oxides in Cultured Cells and Sprague-Dawley Rats publication-title: Toxicol. Res. – volume: 330 start-page: 23 year: 2007 end-page: 31 ident: b0295 article-title: Enhancing effect of surfactants on fexofenadine.HCl transport across the human nasal epithelial cell monolayer publication-title: Int. J. Pharm. – volume: 10 start-page: 105 year: 2009 ident: b0575 article-title: Generation of lung epithelial-like tissue from human embryonic stem cells publication-title: Respir. Res. – volume: 12 start-page: e0170428 year: 2017 ident: b0425 article-title: Development of Combining of Human Bronchial Mucosa Models with XposeALI(R) for Exposure of Air Pollution Nanoparticles publication-title: PLoS One – volume: 4 start-page: 168 year: 2021 ident: b0465 article-title: Second-generation lung-on-a-chip with an array of stretchable alveoli made with a biological membrane publication-title: Commun Biol. – volume: 118 start-page: 68 year: 2017 end-page: 72 ident: b0480 article-title: Establishment and characterization of an in vitro human small airway model (SmallAir) publication-title: Eur. J. Pharm. Biopharm. – volume: 40 start-page: 9 year: 2010 end-page: 15 ident: b0280 article-title: Preparation and evaluation of spray-dried hyaluronic acid microspheres for intranasal delivery of fexofenadine hydrochloride publication-title: Eur. J. Pharm. Sci. – volume: 28 start-page: 258 year: 2014 end-page: 264 ident: b0505 article-title: Feasibility of a 3D human airway epithelial model to study respiratory absorption publication-title: Toxicol. In Vitro – volume: 10 year: 2013 ident: b0040 article-title: Growth of human bronchial epithelial cells at an air-liquid interface alters the response to particle exposure publication-title: Part. Fibre Toxicol. – volume: 11 start-page: e0165225 year: 2016 ident: b0870 article-title: An Optimised Human Cell Culture Model for Alveolar Epithelial Transport publication-title: PLoS One – volume: 315 start-page: L921 year: 2018 end-page: L932 ident: b0580 article-title: Generation of an alveolar epithelial type II cell line from induced pluripotent stem cells publication-title: Am. J. Physiol. Lung Cell. Mol. Physiol. – volume: 13 start-page: 37 year: 2017 ident: b0510 article-title: Protective barrier properties of Rhinosectan((R)) spray (containing xyloglucan) on an organotypic 3D airway tissue model (MucilAir): results of an in vitro study publication-title: Allergy Asthma Clin. Immunol. – volume: 35 start-page: 699 year: 2014 end-page: 710 ident: b0585 article-title: Alveolar epithelial differentiation of human induced pluripotent stem cells in a rotating bioreactor publication-title: Biomaterials – volume: 532 start-page: 537 year: 2017 end-page: 546 ident: b0645 article-title: A comprehensive screening platform for aerosolizable protein formulations for intranasal and pulmonary drug delivery publication-title: Int. J. Pharm. – volume: 23 start-page: 2 year: 2020 ident: b0560 article-title: Inhalable Nanoparticles/Microparticles of an AMPK and Nrf2 Activator for Targeted Pulmonary Drug Delivery as Dry Powder Inhalers publication-title: AAPS J. – volume: 11 start-page: 1467 year: 2011 end-page: 1477 ident: b0225 article-title: Tissue-Specific stem cell differentiation in an in vitro airway model publication-title: Macromol. Biosci. – volume: 5 start-page: 8163 year: 2015 ident: b0335 article-title: Cigarette smoke alters primary human bronchial epithelial cell differentiation at the air-liquid interface publication-title: Sci. Rep. – volume: 14 start-page: 1577 year: 2017 end-page: 1590 ident: b0170 article-title: Activity of Multidrug Resistance-Associated Proteins 1–5 (MRP1−5) in the RPMI 2650 Cell Line and Explants of Human Nasal Turbinate publication-title: Mol. Pharm. – volume: 51 start-page: 516 year: 2014 end-page: 525 ident: b0035 article-title: Submersion and Hypoxia Inhibit Ciliated Cell Differentiation in a Notch-Dependent Manner publication-title: Am. J. Respir. Cell Mol. Biol. – volume: 97 start-page: 1165 year: 2008 end-page: 1178 ident: b0595 article-title: Evaluation of human nasal RPMI 2650 cells grown at an air-liquid interface as a model for nasal drug transport studies publication-title: J. Pharm. Sci. – start-page: 402 year: 2008 end-page: 414 ident: b0405 article-title: In vitro testing of inhalable fly ash at the air liquid interface (Eds.) publication-title: Advanced Environmental Monitoring. Springer – volume: 29 start-page: 1720 year: 2015 end-page: 1728 ident: b0900 article-title: Evaluation of an air-liquid interface cell culture model for studies on the inflammatory and cytotoxic responses to tobacco smoke aerosols publication-title: Toxicol. In Vitro – volume: 423 start-page: 153 year: 2012 end-page: 160 ident: b0290 article-title: Development of udenafil-loaded microemulsions for intranasal delivery: in vitro and in vivo evaluations publication-title: Int. J. Pharm. – volume: 48 start-page: 742 year: 2013 end-page: 748 ident: b0450 article-title: Innate immune response of human alveolar type II cells infected with severe acute respiratory syndrome-coronavirus publication-title: Am. J. Respir. Cell Mol. Biol. – reference: O. Holubovska, D. Bojkova, S. Elli, M. Bechtel, D. Boltz, M. Muzzio, X. Peng, F. Sala, C. Cosentino, A. Mironenko, J. Milde, Y. Lebed, H. Stammer, A. Goy, M. Guerrini, L. Mueller, J. Cinatl, V. Margitich, A.J.W. te Velthuis, Enisamium is an inhibitor of the SARS-CoV-2 RNA polymerase and shows improvement of recovery in COVID-19 patients in an interim analysis of a clinical trial, medRxiv. [Preprint] (2021). – volume: 328 start-page: 77 year: 2006 end-page: 84 ident: b0155 article-title: P-glycoprotein (MDR1) functional activity in human alveolar epithelial cell monolayers, Cell and Tissue publication-title: Research – volume: 10 year: 2013 ident: b0180 article-title: An improved 3D tetraculture system mimicking the cellular organisation at the alveolar barrier to study the potential toxic effects of particles on the lung publication-title: Part. Fibre Toxicol. – volume: 25 start-page: 196 year: 2001 end-page: 202 ident: b0765 article-title: Antibacterial Activity of Apical Surface Fluid from the Human Airway Cell Line Calu-3 publication-title: Am. J. Respir. Cell Mol. Biol. – volume: 19 start-page: 392 year: 2006 end-page: 405 ident: b0830 article-title: An optimized in vitro model of the respiratory tract wall to study particle cell interactions publication-title: J. Aerosol Med. – year: 2014 ident: b0240 article-title: In vitro cell migration and invasion assays publication-title: J. Vis. Exp. – volume: 100 start-page: 681 year: 2011 end-page: 691 ident: b0285 article-title: Poloxamer/cyclodextrin/chitosan-based thermoreversible gel for intranasal delivery of fexofenadine hydrochloride publication-title: J. Pharm. Sci. – volume: 40 start-page: 1953 year: 2012 end-page: 1965 ident: b0710 article-title: Xenobiotic metabolism and disposition in human lung cell models: comparison with in vivo expression profiles publication-title: Drug Metab. Dispos. – volume: 383 start-page: 2595 year: 2020 end-page: 2598 ident: b0460 article-title: Medicaid and Child Health Equity publication-title: N. Engl. J. Med. – volume: 244 start-page: 28 year: 2016 end-page: 34 ident: b0865 article-title: Optimization of the CULTEX((R)) radial flow system for in vitro investigation of lung damaging agents publication-title: Toxicol. Lett. – volume: 10 start-page: 1837 year: 1997 end-page: 1843 ident: b0150 article-title: MDR1-Pgp 170 expression in human bronchus publication-title: Eur. Respir. J. – volume: 102 start-page: 3395 year: 2013 end-page: 3406 ident: b0200 article-title: Quantitative expression of human drug transporter proteins in lung tissues: Analysis of regional, gender, and interindividual differences by liquid chromatography–tandem mass spectrometry publication-title: J. Pharm. Sci. – volume: 2 start-page: 68 year: 2013 end-page: 77 ident: b0445 article-title: MUC1 expression by human airway epithelial cells mediates pseudomonas aeruginosa adhesion publication-title: Front. Biosci. (Elite Ed.) – volume: 10 start-page: 6963 year: 2020 ident: b0250 article-title: Choosing the Right Differentiation Medium to Develop Mucociliary Phenotype of Primary Nasal Epithelial Cells In Vitro publication-title: Sci. Rep. – volume: 10 start-page: 115 year: 1986 end-page: 136 ident: b0030 article-title: The effect of culture conditions on cytodifferentiation of fetal mouse lung respiratory passageways publication-title: Exp. Lung Res. – volume: 27 start-page: 164 year: 2013 end-page: 173 ident: b0410 article-title: Validation of an in vitro exposure system for toxicity assessment of air-delivered nanomaterials publication-title: Toxicol. In Vitro – reference: A. Kuehn, S. Kletting, C. de Souza Carvalho-Wodarz, U. Repnik, G. Griffiths, U. Fischer, E. Meese, H. Huwer, D. Wirth, T. May, N. Schneider-Daum, C.M. Lehr, Human alveolar epithelial cells expressing tight junctions to model the air-blood barrier, ALTEX. 33 (2016) 251-60. – volume: 46 start-page: 798 year: 1986 end-page: 806 ident: b0895 article-title: Growth of Cell Lines and Clinical Specimens of Human Non-Small Cell Lung Cancer in a Serum-free Defined Medium publication-title: Cancer Res. – volume: 12 year: 2020 ident: b0010 article-title: Pulmonary Delivery of Biological Drugs publication-title: Pharmaceutics. – volume: 17 start-page: 136 year: 2020 ident: b0525 article-title: In vitro virucidal activity of Echinaforce(R), an Echinacea purpurea preparation, against coronaviruses, including common cold coronavirus 229E and SARS-CoV-2 publication-title: Virol. J. – volume: 18 start-page: 50 year: 2001 end-page: 59 ident: b0215 article-title: Cytokines in chronic obstructive pulmonary disease publication-title: Eur. Respir. J. – volume: 42 start-page: 210 year: 2010 end-page: 217 ident: b0875 article-title: Arylhydrocarbon receptor activation in NCI-H441 cells and C57BL/6 mice: possible mechanisms for lung dysfunction publication-title: Am. J. Respir. Cell Mol. Biol. – volume: 90 start-page: 1769 year: 2016 end-page: 1783 ident: b0020 article-title: Expert consensus on an in vitro approach to assess pulmonary fibrogenic potential of aerosolized nanomaterials publication-title: Arch. Toxicol. – reference: K.M. Abo, L. Ma, T. Matte, J. Huang, K.D. Alysandratos, R.B. Werder, A. Mithal, M.L. Beermann, J. Lindstrom-Vautrin, G. Mostoslavsky, L. Ikonomou, D.N. Kotton, F. Hawkins, A. Wilson, C. Villacorta-Martin, Human iPSC-derived alveolar and airway epithelial cells can be cultured at air-liquid interface and express SARS-CoV-2 host factors, bioRxiv. PREPRINT (2020). – volume: 34 start-page: 189 year: 2018 end-page: 215 ident: b0090 article-title: Mucins and Their Role in Shaping the Functions of Mucus Barriers publication-title: Annu. Rev. Cell Dev. Biol. – volume: 251 start-page: 189 year: 2013 end-page: 214 ident: b0135 article-title: Cellular immune reactions in the lung publication-title: Immunol. Rev. – volume: 63 start-page: 385 year: 2011 end-page: 391 ident: b0300 article-title: Expression and functional activity of P-glycoprotein in passaged primary human nasal epithelial cell monolayers cultured by the air-liquid interface method for nasal drug transport study publication-title: J. Pharm. Pharmacol. – volume: 6 start-page: 37842 year: 2016 ident: b0845 article-title: Cellular reactions to long-term volatile organic compound (VOC) exposures publication-title: Sci. Rep. – volume: 65 start-page: 12 year: 2013 ident: b0615 article-title: Retinoic acid and hydrocortisone strengthen the barrier function of human RPMI 2650 cells, a model for nasal epithelial permeability publication-title: Cytotechnology – volume: 2013 start-page: 1 year: 2013 end-page: 12 ident: b0855 article-title: Inflammatory and Oxidative Stress Responses of an Alveolar Epithelial Cell Line to Airborne Zinc Oxide Nanoparticles at the Air-Liquid Interface: A Comparison with Conventional, Submerged Cell-Culture Conditions publication-title: BioMed. Res. Int. – volume: 1 start-page: 55 year: 2015 end-page: 65 ident: b0540 article-title: Predicting Respiratory Toxicity Using a Human 3D Airway (EpiAirway™) Model Combined with Multiple Parametric Analysis, Applied publication-title: In Vitro Toxicology. – volume: 109 start-page: 594 year: 2000 end-page: 601 ident: b0235 article-title: Secretory differentiation of serially passaged normal human nasal epithelial cells by retinoic acid: expression of mucin and lysozyme publication-title: Ann. Otol. Rhinol. Laryngol. – volume: 33 start-page: 523 year: 2005 end-page: 530 ident: b0430 article-title: Differential regulation of MUC5AC/Muc5ac and hCLCA-1/mGob-5 expression in airway epithelium publication-title: Am. J. Respir. Cell Mol. Biol. – volume: 207 start-page: 437 year: 2005 end-page: 450 ident: b0400 article-title: Immuno-histochemical detection of MRPs in human lung cells in culture publication-title: Toxicology – volume: 287 start-page: 240 year: 2015 end-page: 245 ident: b0695 article-title: Human bronchial epithelial BEAS-2B cells, an appropriate in vitro model to study heavy metals induced carcinogenesis publication-title: Toxicol. Appl. Pharmacol. – volume: 150 start-page: 195 year: 1998 end-page: 203 ident: b0660 article-title: Barrier Function of Airway Epithelium: Effects of Radiation and Protection by Keratinocyte Growth Factor publication-title: Radiat. Res. – volume: 7 start-page: e32924 year: 2012 ident: b0230 article-title: Comparison of nasal and bronchial epithelial cells obtained from patients with COPD publication-title: PLoS One – volume: 90 start-page: 647 year: 2001 end-page: 658 ident: b0725 article-title: P-Glycoprotein Efflux Pump Expression and Activity in Calu-3 Cells publication-title: J. Pharm. Sci. – volume: 2 start-page: 2111 year: 2007 end-page: 2119 ident: b0190 article-title: Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers publication-title: Nat. Protoc. – volume: 96 start-page: 341 year: 2007 end-page: 350 ident: b0380 article-title: Air-liquid interface (ALI) culture of human bronchial epithelial cell monolayers as an in vitro model for airway drug transport studies publication-title: J. Pharm. Sci. – volume: 88 start-page: 28 year: 1999 end-page: 33 ident: b0175 article-title: MDCK (Madin−Darby Canine Kidney) Cells: A Tool for Membrane Permeability Screening publication-title: J. Pharm. Sci. – volume: 64 start-page: 1621 year: 2012 end-page: 1630 ident: b0620 article-title: Cultivation of RPMI 2650 cells as an in-vitro model for human transmucosal nasal drug absorption studies: optimization of selected culture conditions publication-title: J. Pharm. Pharmacol. – volume: 46 start-page: 219 year: 2018 end-page: 228 ident: b0360 article-title: Inflammatory effects of acrolein, crotonaldehyde and hexanal vapors on human primary bronchial epithelial cells cultured at air-liquid interface publication-title: Toxicol. In Vitro – volume: 1258 start-page: 93 year: 2012 end-page: 99 ident: b0705 article-title: Calcium regulation of tight junction permeability publication-title: Ann. N. Y. Acad. Sci. – volume: 10 start-page: 38 year: 1994 end-page: 47 ident: b0655 article-title: CFfR Expression and Chloride Secretion in Polarized Immortal Human Bronchial Epithelial Cells publication-title: Am. J. Respir. Cell Mol. BioI. – volume: 139 start-page: 186 year: 2019 end-page: 196 ident: b0475 article-title: Pharmacological characterization of the 3D MucilAir nasal model publication-title: Eur. J. Pharm. Biopharm. – volume: 98 year: 2019 ident: b0755 article-title: In vitro model for predicting acute inhalation toxicity by using a Calu-3 epithelium cytotoxicity assay publication-title: J. Pharmacol. Toxicol. Methods – volume: 19 start-page: 30 year: 1998 end-page: 37 ident: b0320 article-title: MUC5B and MUC7 Are Differentially Expressed in Mucous and Serous Cells of Submucosal Glands in Human Bronchial Airways publication-title: Am. J. Respir. Cell Mol. Biol. – volume: 21 start-page: 875 year: 2009 ident: 10.1016/j.ejpb.2023.01.013_b0270 article-title: Increased nasal epithelial ciliary beat frequency associated with lifestyle tobacco smoke exposure publication-title: Inhal. Toxicol. doi: 10.1080/08958370802555898 – volume: 46 start-page: 551 year: 2012 ident: 10.1016/j.ejpb.2023.01.013_b0395 article-title: Albuterol modulates its own transepithelial flux via changes in paracellular permeability publication-title: Am. J. Respir. Cell Mol. Biol. doi: 10.1165/rcmb.2011-0220OC – volume: 28 start-page: 251 year: 2016 ident: 10.1016/j.ejpb.2023.01.013_b0545 article-title: Assessment of biological responses of EpiAirway 3-D cell constructs versus A549 cells for determining toxicity of ambient air pollution publication-title: Inhal. Toxicol. doi: 10.3109/08958378.2016.1157227 – volume: 20 start-page: 1690 year: 2003 ident: 10.1016/j.ejpb.2023.01.013_b0245 article-title: Serially Passaged Human Nasal Epithelial Cell Monolayer for in Vitro Drug Transport Studies publication-title: Pharm. Res. doi: 10.1023/A:1026112107100 – volume: 34 year: 2014 ident: 10.1016/j.ejpb.2023.01.013_b0665 article-title: Effect of epithelium ATP release on cyclic pressure-induced airway mucus secretion publication-title: Biosci. Rep. doi: 10.1042/BSR20130109 – volume: 262 start-page: L713 year: 1992 ident: 10.1016/j.ejpb.2023.01.013_b0315 article-title: Differentiated structure and function of cultures from human tracheal epithelium publication-title: Am. J. Phys. Anthropol. – volume: 88 start-page: 28 year: 1999 ident: 10.1016/j.ejpb.2023.01.013_b0175 article-title: MDCK (Madin−Darby Canine Kidney) Cells: A Tool for Membrane Permeability Screening publication-title: J. Pharm. Sci. doi: 10.1021/js9803205 – volume: 29 start-page: 234 year: 2015 ident: 10.1016/j.ejpb.2023.01.013_b0675 article-title: A coculture model of the lung-blood barrier: the role of activated phagocytic cells publication-title: Toxicol. In Vitro doi: 10.1016/j.tiv.2014.10.024 – volume: 99 start-page: 133 year: 2016 ident: 10.1016/j.ejpb.2023.01.013_b0055 article-title: Surface area is the biologically most effective dose metric for acute nanoparticle toxicity in the lung publication-title: J. Aerosol Sci doi: 10.1016/j.jaerosci.2015.12.006 – volume: 134 start-page: 1555 year: 2001 ident: 10.1016/j.ejpb.2023.01.013_b0720 article-title: Evidence of P-glycoprotein mediated apical to basolateral transport of flunisolide in human broncho-tracheal epithelial cells (Calu-3) publication-title: Br. J. Pharmacol. doi: 10.1038/sj.bjp.0704390 – volume: 183 start-page: 1901 year: 2020 ident: 10.1016/j.ejpb.2023.01.013_b0570 article-title: Case Study: Prolonged Infectious SARS-CoV-2 Shedding from an Asymptomatic Immunocompromised Individual with Cancer publication-title: Cell doi: 10.1016/j.cell.2020.10.049 – volume: 38 start-page: 285 year: 2010 ident: 10.1016/j.ejpb.2023.01.013_b0805 article-title: The Pharmaceutical Aerosol Deposition Device On Cell Cultures (PADDOCC) In Vitro System: Design and Experimental Protocol publication-title: ATLA. – volume: 287 start-page: 240 year: 2015 ident: 10.1016/j.ejpb.2023.01.013_b0695 article-title: Human bronchial epithelial BEAS-2B cells, an appropriate in vitro model to study heavy metals induced carcinogenesis publication-title: Toxicol. Appl. Pharmacol. doi: 10.1016/j.taap.2015.06.008 – volume: 110 start-page: 1011 year: 2001 ident: 10.1016/j.ejpb.2023.01.013_b0255 article-title: Ciliary beat frequency in cultured human nasal epithelial cells publication-title: Ann. Otol. Rhinol. Laryngol. doi: 10.1177/000348940111001104 – ident: 10.1016/j.ejpb.2023.01.013_b0820 doi: 10.1016/0887-2333(87)90005-1 – volume: 12 year: 2020 ident: 10.1016/j.ejpb.2023.01.013_b0100 article-title: Nose-to-Brain Delivery publication-title: Pharmaceutics. doi: 10.3390/pharmaceutics12020138 – volume: 10 start-page: e0135690 year: 2015 ident: 10.1016/j.ejpb.2023.01.013_b0750 article-title: Permeation of Therapeutic Drugs in Different Formulations across the Airway Epithelium In Vitro publication-title: PLoS One doi: 10.1371/journal.pone.0135690 – ident: 10.1016/j.ejpb.2023.01.013_b0910 doi: 10.14573/altex.1607191 – volume: 109 start-page: 594 year: 2000 ident: 10.1016/j.ejpb.2023.01.013_b0235 article-title: Secretory differentiation of serially passaged normal human nasal epithelial cells by retinoic acid: expression of mucin and lysozyme publication-title: Ann. Otol. Rhinol. Laryngol. doi: 10.1177/000348940010900612 – volume: 264 start-page: L560 year: 1993 ident: 10.1016/j.ejpb.2023.01.013_b0325 article-title: Enhanced Na+ transport in an air-liquid culture system publication-title: American Physiol. Soc. – volume: 251 start-page: 189 year: 2013 ident: 10.1016/j.ejpb.2023.01.013_b0135 article-title: Cellular immune reactions in the lung publication-title: Immunol. Rev. doi: 10.1111/imr.12020 – volume: 16 start-page: 382 year: 1999 ident: 10.1016/j.ejpb.2023.01.013_b0785 article-title: In Vitro Evaluation of Microparticles and Polymer Gels for Use as Nasal Platforms for Protein Delivery publication-title: Pharm. Res. doi: 10.1023/A:1018869601502 – volume: 319 start-page: 1132 year: 2004 ident: 10.1016/j.ejpb.2023.01.013_b0770 article-title: Regulation of apical surface fluid and protein secretion in human airway epithelial cell line Calu-3 publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2004.05.101 – volume: 9 start-page: 500 year: 2019 ident: 10.1016/j.ejpb.2023.01.013_b0355 article-title: Optimization of Normal Human Bronchial Epithelial (NHBE) Cell 3D Cultures for in vitro Lung Model Studies publication-title: Sci. Rep. doi: 10.1038/s41598-018-36735-z – volume: 11 year: 2019 ident: 10.1016/j.ejpb.2023.01.013_b0605 article-title: Improved In Vitro Model for Intranasal Mucosal Drug Delivery: Primary Olfactory and Respiratory Epithelial Cells Compared with the Permanent Nasal Cell Line RPMI 2650 publication-title: Pharmaceutics. doi: 10.3390/pharmaceutics11080367 – ident: 10.1016/j.ejpb.2023.01.013_b0455 doi: 10.1101/2020.06.29.174623 – volume: 383 start-page: 2595 year: 2020 ident: 10.1016/j.ejpb.2023.01.013_b0460 article-title: Medicaid and Child Health Equity publication-title: N. Engl. J. Med. doi: 10.1056/NEJMp2030646 – year: 2014 ident: 10.1016/j.ejpb.2023.01.013_b0060 article-title: In vitro cell culture model for toxic inhaled chemical testing publication-title: J. Vis. Exp. doi: 10.3791/51539-v – volume: 23 start-page: 119 year: 2010 ident: 10.1016/j.ejpb.2023.01.013_b0775 article-title: Drug Transport Across Pulmonary Epithelial Cell Monolayers: Effects of Particle Size, Apical Liquid Volume, and Deposition Technique publication-title: J. Aerosol Med. Pulm. Drug Deliv. doi: 10.1089/jamp.2009.0757 – volume: 12 start-page: 2742 year: 2015 ident: 10.1016/j.ejpb.2023.01.013_b0160 article-title: Microarray Determination of the Expression of Drug Transporters in Humans and Animal Species Used for the Investigation of Nasal Absorption publication-title: Mol. Pharm. doi: 10.1021/acs.molpharmaceut.5b00103 – volume: 139 start-page: 186 year: 2019 ident: 10.1016/j.ejpb.2023.01.013_b0475 article-title: Pharmacological characterization of the 3D MucilAir nasal model publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/j.ejpb.2019.04.002 – volume: 26 start-page: 414 year: 2005 ident: 10.1016/j.ejpb.2023.01.013_b0680 article-title: Drug permeability in 16HBE14o- airway cell layers correlates with absorption from the isolated perfused rat lung publication-title: Eur. J. Pharm. Sci. doi: 10.1016/j.ejps.2005.07.010 – volume: 10 start-page: 243 year: 2009 ident: 10.1016/j.ejpb.2023.01.013_b0790 article-title: New Generation of Hybrid Poly/Oligosaccharide Nanoparticles as Carriers for the Nasal Delivery of Macromolecules publication-title: Biomacromolecules doi: 10.1021/bm800975j – ident: 10.1016/j.ejpb.2023.01.013_b0205 – year: 2014 ident: 10.1016/j.ejpb.2023.01.013_b0240 article-title: In vitro cell migration and invasion assays publication-title: J. Vis. Exp. doi: 10.3791/51046-v – volume: 63 start-page: 385 year: 2011 ident: 10.1016/j.ejpb.2023.01.013_b0300 article-title: Expression and functional activity of P-glycoprotein in passaged primary human nasal epithelial cell monolayers cultured by the air-liquid interface method for nasal drug transport study publication-title: J. Pharm. Pharmacol. doi: 10.1111/j.2042-7158.2010.01221.x – ident: 10.1016/j.ejpb.2023.01.013_b0555 doi: 10.1101/2021.01.05.21249237 – volume: 9 start-page: 1 year: 1992 ident: 10.1016/j.ejpb.2023.01.013_b0115 article-title: Drug Metabolism in the Nasal Mucosa publication-title: Pharm. Res. doi: 10.1023/A:1018911206646 – ident: 10.1016/j.ejpb.2023.01.013_b0385 doi: 10.1177/009127002762491370 – volume: 423 start-page: 153 year: 2012 ident: 10.1016/j.ejpb.2023.01.013_b0290 article-title: Development of udenafil-loaded microemulsions for intranasal delivery: in vitro and in vivo evaluations publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2011.12.028 – volume: 38 start-page: 497 year: 2015 ident: 10.1016/j.ejpb.2023.01.013_b0095 article-title: The Effect of Cilia and the Mucociliary Clearance on Successful Drug Delivery publication-title: Biol. Pharm. Bull. doi: 10.1248/bpb.b14-00398 – volume: 10 start-page: 115 year: 1986 ident: 10.1016/j.ejpb.2023.01.013_b0030 article-title: The effect of culture conditions on cytodifferentiation of fetal mouse lung respiratory passageways publication-title: Exp. Lung Res. doi: 10.3109/01902148609061488 – volume: 9 start-page: 1717 year: 2012 ident: 10.1016/j.ejpb.2023.01.013_b0390 article-title: Deposition, diffusion and transport mechanism of dry powder microparticulate salbutamol, at the respiratory epithelia publication-title: Mol. Pharm. doi: 10.1021/mp200620m – volume: 162 start-page: 301 year: 2018 ident: 10.1016/j.ejpb.2023.01.013_b0495 article-title: A 3D Human Airway Model Enables Prediction of Respiratory Toxicity of Inhaled Drugs In Vitro publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfx255 – volume: 1 year: 2020 ident: 10.1016/j.ejpb.2023.01.013_b0535 article-title: Characterization and Treatment of SARS-CoV-2 in Nasal and Bronchial Human Airway Epithelia publication-title: Cell Rep Med. – ident: 10.1016/j.ejpb.2023.01.013_b0085 – volume: 11 start-page: e0165225 year: 2016 ident: 10.1016/j.ejpb.2023.01.013_b0870 article-title: An Optimised Human Cell Culture Model for Alveolar Epithelial Transport publication-title: PLoS One doi: 10.1371/journal.pone.0165225 – volume: 60 start-page: 5074 year: 2000 ident: 10.1016/j.ejpb.2023.01.013_b0110 article-title: Human Cytochrome P450 CYP2A13: Predominant Expression in the Respiratory Tract and Its High Efficiency Metabolic Activation of a Tobacco-specific Carcinogen, 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone publication-title: Cancer Res. – volume: 33 start-page: 523 year: 2005 ident: 10.1016/j.ejpb.2023.01.013_b0430 article-title: Differential regulation of MUC5AC/Muc5ac and hCLCA-1/mGob-5 expression in airway epithelium publication-title: Am. J. Respir. Cell Mol. Biol. doi: 10.1165/rcmb.2004-0220RC – volume: 51 start-page: 516 year: 2014 ident: 10.1016/j.ejpb.2023.01.013_b0035 article-title: Submersion and Hypoxia Inhibit Ciliated Cell Differentiation in a Notch-Dependent Manner publication-title: Am. J. Respir. Cell Mol. Biol. doi: 10.1165/rcmb.2013-0237OC – volume: 64 start-page: 1621 year: 2012 ident: 10.1016/j.ejpb.2023.01.013_b0620 article-title: Cultivation of RPMI 2650 cells as an in-vitro model for human transmucosal nasal drug absorption studies: optimization of selected culture conditions publication-title: J. Pharm. Pharmacol. doi: 10.1111/j.2042-7158.2012.01540.x – volume: 19 start-page: 392 year: 2006 ident: 10.1016/j.ejpb.2023.01.013_b0830 article-title: An optimized in vitro model of the respiratory tract wall to study particle cell interactions publication-title: J. Aerosol Med. doi: 10.1089/jam.2006.19.392 – volume: 11 start-page: 26 year: 2015 ident: 10.1016/j.ejpb.2023.01.013_b0210 article-title: Cytokine profiles in nasal fluid of patients with seasonal or persistent allergic rhinitis, Allergy Asthma publication-title: Clin. Immunol. – volume: 33 start-page: 1423 year: 2005 ident: 10.1016/j.ejpb.2023.01.013_b0105 article-title: Expression of cytochrome p450 and other biotransformation genes in fetal and adult human nasal mucosa publication-title: Drug Metab. Dispos. doi: 10.1124/dmd.105.005769 – volume: 315 start-page: L921 year: 2018 ident: 10.1016/j.ejpb.2023.01.013_b0580 article-title: Generation of an alveolar epithelial type II cell line from induced pluripotent stem cells publication-title: Am. J. Physiol. Lung Cell. Mol. Physiol. doi: 10.1152/ajplung.00357.2017 – volume: 2 start-page: 2111 year: 2007 ident: 10.1016/j.ejpb.2023.01.013_b0190 article-title: Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers publication-title: Nat. Protoc. doi: 10.1038/nprot.2007.303 – volume: 290 start-page: L1117 year: 2006 ident: 10.1016/j.ejpb.2023.01.013_b0310 article-title: Rescue of DeltaF508-CFTR trafficking and gating in human cystic fibrosis airway primary cultures by small molecules publication-title: Am. J. Physiol. Lung Cell. Mol. Physiol. doi: 10.1152/ajplung.00169.2005 – volume: 128 start-page: 337 year: 2018 ident: 10.1016/j.ejpb.2023.01.013_b0075 article-title: Recent advances in carrier mediated nose-to-brain delivery of pharmaceutics publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/j.ejpb.2018.05.009 – volume: 10 year: 2013 ident: 10.1016/j.ejpb.2023.01.013_b0180 article-title: An improved 3D tetraculture system mimicking the cellular organisation at the alveolar barrier to study the potential toxic effects of particles on the lung publication-title: Part. Fibre Toxicol. doi: 10.1186/1743-8977-10-31 – volume: 102 start-page: 3395 year: 2013 ident: 10.1016/j.ejpb.2023.01.013_b0200 article-title: Quantitative expression of human drug transporter proteins in lung tissues: Analysis of regional, gender, and interindividual differences by liquid chromatography–tandem mass spectrometry publication-title: J. Pharm. Sci. doi: 10.1002/jps.23606 – ident: 10.1016/j.ejpb.2023.01.013_b0685 doi: 10.1165/ajrcmb.17.5.2685 – volume: 14 start-page: 3941 year: 2020 ident: 10.1016/j.ejpb.2023.01.013_b0565 article-title: Use of EpiAlveolar Lung Model to Predict Fibrotic Potential of Multiwalled Carbon Nanotubes publication-title: ACS Nano doi: 10.1021/acsnano.9b06860 – volume: 243 start-page: 359 year: 1998 ident: 10.1016/j.ejpb.2023.01.013_b0810 article-title: Characterization of the A549 Cell Line as a Type II Pulmonary Epithelial Cell Model for Drug Metabolism publication-title: Exp. Cell Res. doi: 10.1006/excr.1998.4172 – volume: 10 year: 2020 ident: 10.1016/j.ejpb.2023.01.013_b0065 article-title: Parametric Optimization of an Air-Liquid Interface System for Flow-Through Inhalation Exposure to Nanoparticles: Assessing Dosimetry and Intracellular Uptake of CeO2 Nanoparticles publication-title: Nanomaterials (Basel). doi: 10.3390/nano10122369 – volume: 96 start-page: 341 year: 2007 ident: 10.1016/j.ejpb.2023.01.013_b0380 article-title: Air-liquid interface (ALI) culture of human bronchial epithelial cell monolayers as an in vitro model for airway drug transport studies publication-title: J. Pharm. Sci. doi: 10.1002/jps.20803 – volume: 515 start-page: 1 year: 2016 ident: 10.1016/j.ejpb.2023.01.013_b0625 article-title: Application of RPMI 2650 as a cell model to evaluate solid formulations for intranasal delivery of drugs publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2016.09.086 – volume: 32 start-page: 665 year: 2015 ident: 10.1016/j.ejpb.2023.01.013_b0610 article-title: The Characterization of the Human Nasal Epithelial Cell Line RPMI 2650 Under Different Culture Conditions and Their Optimization for an Appropriate in vitro Nasal Model publication-title: Pharm. Res. doi: 10.1007/s11095-014-1494-0 – volume: 13 year: 2018 ident: 10.1016/j.ejpb.2023.01.013_b0470 article-title: Human Pulmonary 3D Models For Translational Research publication-title: Biotechnol. J. doi: 10.1002/biot.201700341 – ident: 10.1016/j.ejpb.2023.01.013_b0905 doi: 10.14573/altex.1511131 – volume: 508 start-page: 22 year: 2016 ident: 10.1016/j.ejpb.2023.01.013_b0145 article-title: Expression of P-glycoprotein in excised human nasal mucosa and optimized models of RPMI 2650 cells publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2016.05.010 – volume: 390 start-page: 19 year: 2010 ident: 10.1016/j.ejpb.2023.01.013_b0795 article-title: CAF01 liposomes as a mucosal vaccine adjuvant: In vitro and in vivo investigations publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2009.10.043 – volume: 39 start-page: 9370 year: 2005 ident: 10.1016/j.ejpb.2023.01.013_b0045 article-title: Oxide Nanoparticle Uptake in Human Lung Fibroblasts: Effects of Particle Size, Agglomeration, and Diffusion at Low Concentrations publication-title: Environ. Sci. Tech. doi: 10.1021/es051043o – volume: 593 year: 2021 ident: 10.1016/j.ejpb.2023.01.013_b0650 article-title: A combo-strategy to improve brain delivery of antiepileptic drugs: Focus on BCRP and intranasal administration publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2020.120161 – volume: 186 start-page: 3392 year: 2011 ident: 10.1016/j.ejpb.2023.01.013_b0880 article-title: CCL20/CCR6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial (NCI-H292) cells publication-title: J. Immunol. doi: 10.4049/jimmunol.1003377 – volume: 11 start-page: e0164438 year: 2016 ident: 10.1016/j.ejpb.2023.01.013_b0825 article-title: Long Term Culture of the A549 Cancer Cell Line Promotes Multilamellar Body Formation and Differentiation towards an Alveolar Type II Pneumocyte Phenotype publication-title: PLoS One doi: 10.1371/journal.pone.0164438 – volume: 4 start-page: 91 year: 2018 ident: 10.1016/j.ejpb.2023.01.013_b0070 article-title: Air-Liquid Interface In Vitro Models for Respiratory Toxicology Research: Consensus Workshop and Recommendations, Applied publication-title: In Vitro Toxicology. doi: 10.1089/aivt.2017.0034 – volume: 10 start-page: 105 year: 2009 ident: 10.1016/j.ejpb.2023.01.013_b0575 article-title: Generation of lung epithelial-like tissue from human embryonic stem cells publication-title: Respir. Res. doi: 10.1186/1465-9921-10-105 – volume: 1258 start-page: 93 year: 2012 ident: 10.1016/j.ejpb.2023.01.013_b0705 article-title: Calcium regulation of tight junction permeability publication-title: Ann. N. Y. Acad. Sci. doi: 10.1111/j.1749-6632.2012.06539.x – volume: 40 start-page: 9 year: 2010 ident: 10.1016/j.ejpb.2023.01.013_b0280 article-title: Preparation and evaluation of spray-dried hyaluronic acid microspheres for intranasal delivery of fexofenadine hydrochloride publication-title: Eur. J. Pharm. Sci. doi: 10.1016/j.ejps.2010.02.002 – volume: 4 start-page: 168 year: 2021 ident: 10.1016/j.ejpb.2023.01.013_b0465 article-title: Second-generation lung-on-a-chip with an array of stretchable alveoli made with a biological membrane publication-title: Commun Biol. doi: 10.1038/s42003-021-01695-0 – volume: 71 start-page: 318 year: 2009 ident: 10.1016/j.ejpb.2023.01.013_b0800 article-title: The permeability of large molecular weight solutes following particle delivery to air-interfaced cells that model the respiratory mucosa publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/j.ejpb.2008.09.006 – volume: 121 start-page: 332 year: 2009 ident: 10.1016/j.ejpb.2023.01.013_b0915 article-title: Airway mucus: the good, the bad, the sticky publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2008.11.001 – volume: 150 start-page: 661 year: 2018 ident: 10.1016/j.ejpb.2023.01.013_b0140 article-title: The micromechanics of lung alveoli: structure and function of surfactant and tissue components publication-title: Histochem. Cell Biol. doi: 10.1007/s00418-018-1747-9 – ident: 10.1016/j.ejpb.2023.01.013_b0635 doi: 10.1021/acs.molpharmaceut.8b00087 – volume: 400 start-page: 59 year: 2010 ident: 10.1016/j.ejpb.2023.01.013_b0275 article-title: Characterization and in vitro evaluation of freeze-dried microparticles composed of granisetron-cyclodextrin complex and carboxymethylcellulose for intranasal delivery publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2010.08.030 – volume: 35 start-page: 699 year: 2014 ident: 10.1016/j.ejpb.2023.01.013_b0585 article-title: Alveolar epithelial differentiation of human induced pluripotent stem cells in a rotating bioreactor publication-title: Biomaterials doi: 10.1016/j.biomaterials.2013.10.018 – volume: 27 start-page: 767 year: 2015 ident: 10.1016/j.ejpb.2023.01.013_b0120 article-title: Gene expression and immunochemical localization of major cytochrome P450 drug-metabolizing enzymes in bovine nasal olfactory and respiratory mucosa publication-title: Inhal. Toxicol. doi: 10.3109/08958378.2015.1066903 – volume: 18 start-page: 47 year: 2003 ident: 10.1016/j.ejpb.2023.01.013_b0015 article-title: P ermeability of porcine nasal mucosa correlated with human nasal absorption publication-title: Eur. J. Pharm. Sci. doi: 10.1016/S0928-0987(02)00240-3 – volume: 5 start-page: 8163 year: 2015 ident: 10.1016/j.ejpb.2023.01.013_b0335 article-title: Cigarette smoke alters primary human bronchial epithelial cell differentiation at the air-liquid interface publication-title: Sci. Rep. doi: 10.1038/srep08163 – volume: 18 start-page: 50 year: 2001 ident: 10.1016/j.ejpb.2023.01.013_b0215 article-title: Cytokines in chronic obstructive pulmonary disease publication-title: Eur. Respir. J. doi: 10.1183/09031936.01.00229701 – volume: 150 start-page: 195 year: 1998 ident: 10.1016/j.ejpb.2023.01.013_b0660 article-title: Barrier Function of Airway Epithelium: Effects of Radiation and Protection by Keratinocyte Growth Factor publication-title: Radiat. Res. doi: 10.2307/3579855 – volume: 90 start-page: 647 year: 2001 ident: 10.1016/j.ejpb.2023.01.013_b0725 article-title: P-Glycoprotein Efflux Pump Expression and Activity in Calu-3 Cells publication-title: J. Pharm. Sci. doi: 10.1002/1520-6017(200105)90:5<647::AID-JPS1021>3.0.CO;2-G – volume: 52 start-page: 265 year: 2000 ident: 10.1016/j.ejpb.2023.01.013_b0185 article-title: CULTEX — an alternative technique for cultivation and exposure of cells of the respiratory tract to airborne pollutants at the air/liquid interface publication-title: Exp. Toxicol. Pathol. doi: 10.1016/S0940-2993(00)80044-5 – volume: 21 year: 2020 ident: 10.1016/j.ejpb.2023.01.013_b0550 article-title: Characterization of ABC Transporters in EpiAirway, a Cellular Model of Normal Human Bronchial Epithelium publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms21093190 – volume: 6 start-page: 32 year: 2009 ident: 10.1016/j.ejpb.2023.01.013_b0850 article-title: A dose-controlled system for air-liquid interface cell exposure and application to zinc oxide nanoparticles publication-title: Part. Fibre Toxicol. doi: 10.1186/1743-8977-6-32 – volume: 207 start-page: 437 year: 2005 ident: 10.1016/j.ejpb.2023.01.013_b0400 article-title: Immuno-histochemical detection of MRPs in human lung cells in culture publication-title: Toxicology doi: 10.1016/j.tox.2004.10.014 – volume: 29 start-page: 502 year: 2015 ident: 10.1016/j.ejpb.2023.01.013_b0415 article-title: Toxicity of copper oxide nanoparticles in lung epithelial cells exposed at the air-liquid interface compared with in vivo assessment publication-title: Toxicol. In Vitro doi: 10.1016/j.tiv.2014.12.023 – volume: 65 start-page: 12 year: 2013 ident: 10.1016/j.ejpb.2023.01.013_b0615 article-title: Retinoic acid and hydrocortisone strengthen the barrier function of human RPMI 2650 cells, a model for nasal epithelial permeability publication-title: Cytotechnology doi: 10.1007/s10616-012-9493-7 – volume: 12 start-page: 305 year: 2005 ident: 10.1016/j.ejpb.2023.01.013_b0260 article-title: Air-liquid interface culture of serially passaged human nasal epithelial cell monolayer for in vitro drug transport studies publication-title: Drug Deliv. doi: 10.1080/10717540500177009 – volume: 61 start-page: 583 year: 2009 ident: 10.1016/j.ejpb.2023.01.013_b0165 article-title: RT-PCR analysis of ABC, SLC and SLCO drug transporters in human lung epithelial cell models publication-title: J. Pharm. Pharmacol. doi: 10.1211/jpp.61.05.0006 – volume: 50 start-page: 1040 year: 2014 ident: 10.1016/j.ejpb.2023.01.013_b0330 article-title: Cigarette Smoke-Induced Disruption of Bronchial Epithelial Tight Junctions Is Prevented by Transforming Growth Factor-β publication-title: Am. J. Respir. Cell Mol. Biol. doi: 10.1165/rcmb.2013-0090OC – volume: 318 start-page: L1063 year: 2020 ident: 10.1016/j.ejpb.2023.01.013_b0345 article-title: Structural and functional variations in human bronchial epithelial cells cultured in air-liquid interface using different growth media publication-title: Am. J. Physiol. Lung Cell. Mol. Physiol. doi: 10.1152/ajplung.00190.2019 – volume: 50 start-page: 292 year: 2014 ident: 10.1016/j.ejpb.2023.01.013_b0340 article-title: Directional secretomes reflect polarity-specific functions in an in vitro model of human bronchial epithelium publication-title: Am. J. Respir. Cell Mol. Biol. doi: 10.1165/rcmb.2013-0188OC – ident: 10.1016/j.ejpb.2023.01.013_b0375 doi: 10.1016/S0928-0987(97)10019-7 – volume: 141 start-page: 210 year: 2019 ident: 10.1016/j.ejpb.2023.01.013_b0760 article-title: In vitro investigation on the impact of airway mucus on drug dissolution and absorption at the air-epithelium interface in the lungs publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/j.ejpb.2019.05.022 – volume: 6 start-page: 37842 year: 2016 ident: 10.1016/j.ejpb.2023.01.013_b0845 article-title: Cellular reactions to long-term volatile organic compound (VOC) exposures publication-title: Sci. Rep. doi: 10.1038/srep37842 – volume: 330 start-page: 23 year: 2007 ident: 10.1016/j.ejpb.2023.01.013_b0295 article-title: Enhancing effect of surfactants on fexofenadine.HCl transport across the human nasal epithelial cell monolayer publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2006.08.043 – volume: 9 start-page: 31 year: 2006 ident: 10.1016/j.ejpb.2023.01.013_b0025 article-title: In vitro - In vivo Correlation: From Theory to Applications publication-title: J. Pharm. Pharmaceut. Sci. – volume: 50 start-page: 975 year: 2019 ident: 10.1016/j.ejpb.2023.01.013_b0220 article-title: The Cytokines of Asthma publication-title: Immunity doi: 10.1016/j.immuni.2019.03.018 – volume: 11 start-page: 568 year: 1994 ident: 10.1016/j.ejpb.2023.01.013_b0690 article-title: Primary and Immortalized (BEAS 2B) Human Bronchial Epithelial Cells Have Significant Antioxidative Capacity In Vitro publication-title: Am. J. Respir. Cell Mol. BioI. doi: 10.1165/ajrcmb.11.5.7946385 – volume: 84 start-page: 736 year: 2004 ident: 10.1016/j.ejpb.2023.01.013_b0890 article-title: Lung epithelial cell lines in coculture with human pulmonary microvascular endothelial cells: development of an alveolo-capillary barrier in vitro publication-title: Lab. Invest. doi: 10.1038/labinvest.3700081 – volume: 31 start-page: 181 year: 2015 ident: 10.1016/j.ejpb.2023.01.013_b0050 article-title: Toxicity of Two Different Sized Lanthanum Oxides in Cultured Cells and Sprague-Dawley Rats publication-title: Toxicol. Res. doi: 10.5487/TR.2015.31.2.181 – volume: 10 start-page: 6963 year: 2020 ident: 10.1016/j.ejpb.2023.01.013_b0250 article-title: Choosing the Right Differentiation Medium to Develop Mucociliary Phenotype of Primary Nasal Epithelial Cells In Vitro publication-title: Sci. Rep. doi: 10.1038/s41598-020-63922-8 – volume: 153 start-page: 106 year: 2020 ident: 10.1016/j.ejpb.2023.01.013_b0005 article-title: QbD-driven development of intranasal lipid nanoparticles for depression treatment publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/j.ejpb.2020.04.011 – volume: 12 year: 2020 ident: 10.1016/j.ejpb.2023.01.013_b0010 article-title: Pulmonary Delivery of Biological Drugs publication-title: Pharmaceutics. doi: 10.3390/pharmaceutics12111025 – volume: 27 start-page: 1987 year: 2013 ident: 10.1016/j.ejpb.2023.01.013_b0715 article-title: Comet assay and air-liquid interface exposure system: a new combination to evaluate genotoxic effects of cigarette whole smoke in human lung cell lines publication-title: Toxicol. In Vitro doi: 10.1016/j.tiv.2013.06.016 – volume: 59 start-page: 395 year: 2009 ident: 10.1016/j.ejpb.2023.01.013_b0780 article-title: Permeation of losartan across human respiratory epithelium: An in vitro study with Calu-3 cells publication-title: Acta Pharm. doi: 10.2478/v10007-009-0038-3 – volume: 97 start-page: 1165 year: 2008 ident: 10.1016/j.ejpb.2023.01.013_b0595 article-title: Evaluation of human nasal RPMI 2650 cells grown at an air-liquid interface as a model for nasal drug transport studies publication-title: J. Pharm. Sci. doi: 10.1002/jps.21031 – volume: 17 start-page: 628 year: 2016 ident: 10.1016/j.ejpb.2023.01.013_b0125 article-title: Drug-metabolizing Enzymes and Efflux Transporters in Nasal Epithelium: Influence on the Bioavailability of Intranasally Administered Drugs, Curr Drugs publication-title: Metabolism – volume: 10 start-page: 38 year: 1994 ident: 10.1016/j.ejpb.2023.01.013_b0655 article-title: CFfR Expression and Chloride Secretion in Polarized Immortal Human Bronchial Epithelial Cells publication-title: Am. J. Respir. Cell Mol. BioI. doi: 10.1165/ajrcmb.10.1.7507342 – volume: 90 start-page: 1769 year: 2016 ident: 10.1016/j.ejpb.2023.01.013_b0020 article-title: Expert consensus on an in vitro approach to assess pulmonary fibrogenic potential of aerosolized nanomaterials publication-title: Arch. Toxicol. doi: 10.1007/s00204-016-1717-8 – volume: 1 start-page: 55 year: 2015 ident: 10.1016/j.ejpb.2023.01.013_b0540 article-title: Predicting Respiratory Toxicity Using a Human 3D Airway (EpiAirway™) Model Combined with Multiple Parametric Analysis, Applied publication-title: In Vitro Toxicology. doi: 10.1089/aivt.2014.0003 – volume: 42 start-page: 210 year: 2010 ident: 10.1016/j.ejpb.2023.01.013_b0875 article-title: Arylhydrocarbon receptor activation in NCI-H441 cells and C57BL/6 mice: possible mechanisms for lung dysfunction publication-title: Am. J. Respir. Cell Mol. Biol. doi: 10.1165/rcmb.2008-0228OC – volume: 74 start-page: 290 year: 2010 ident: 10.1016/j.ejpb.2023.01.013_b0600 article-title: RPMI 2650 epithelial model and three-dimensional reconstructed human nasal mucosa as in vitro models for nasal permeation studies publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/j.ejpb.2009.08.008 – volume: 9 start-page: 1 year: 2019 ident: 10.1016/j.ejpb.2023.01.013_b0835 article-title: Partial pressure of oxygen in the human body: a general review publication-title: Am J Blood Res. – volume: 10 start-page: 6188 year: 2020 ident: 10.1016/j.ejpb.2023.01.013_b0730 article-title: The impact of ABCB1 gene polymorphism and its expression on non-small-cell lung cancer development, progression and therapy - preliminary report publication-title: Sci. Rep. doi: 10.1038/s41598-020-63265-4 – volume: 23 start-page: 2 year: 2020 ident: 10.1016/j.ejpb.2023.01.013_b0560 article-title: Inhalable Nanoparticles/Microparticles of an AMPK and Nrf2 Activator for Targeted Pulmonary Drug Delivery as Dry Powder Inhalers publication-title: AAPS J. doi: 10.1208/s12248-020-00531-3 – volume: 34 start-page: 189 year: 2018 ident: 10.1016/j.ejpb.2023.01.013_b0090 article-title: Mucins and Their Role in Shaping the Functions of Mucus Barriers publication-title: Annu. Rev. Cell Dev. Biol. doi: 10.1146/annurev-cellbio-100617-062818 – volume: 28 start-page: 258 year: 2014 ident: 10.1016/j.ejpb.2023.01.013_b0505 article-title: Feasibility of a 3D human airway epithelial model to study respiratory absorption publication-title: Toxicol. In Vitro doi: 10.1016/j.tiv.2013.10.025 – volume: 585 start-page: 584 year: 2020 ident: 10.1016/j.ejpb.2023.01.013_b0530 article-title: Hydroxychloroquine use against SARS-CoV-2 infection in non-human primates publication-title: Nature doi: 10.1038/s41586-020-2558-4 – ident: 10.1016/j.ejpb.2023.01.013_b0590 doi: 10.1101/2020.06.03.132639 – volume: 10 year: 2018 ident: 10.1016/j.ejpb.2023.01.013_b0515 article-title: Combining MucilAir and Vitrocell((R)) Powder Chamber for the In Vitro Evaluation of Nasal Ointments in the Context of Aerosolized Pollen publication-title: Pharmaceutics. doi: 10.3390/pharmaceutics10020056 – volume: 16 start-page: 45 year: 2004 ident: 10.1016/j.ejpb.2023.01.013_b0420 article-title: A novel method to aerosolize powder for short inhalation exposures at high concentrations: isolated rat lungs exposed to respirable diesel soot publication-title: Inhal. Toxicol. doi: 10.1080/08958370490258381 – volume: 244 start-page: 28 year: 2016 ident: 10.1016/j.ejpb.2023.01.013_b0865 article-title: Optimization of the CULTEX((R)) radial flow system for in vitro investigation of lung damaging agents publication-title: Toxicol. Lett. doi: 10.1016/j.toxlet.2015.09.003 – volume: 5 start-page: 772 year: 2008 ident: 10.1016/j.ejpb.2023.01.013_b0130 article-title: Airway epithelial cells: current concepts and challenges publication-title: Proc. Am. Thorac. Soc. doi: 10.1513/pats.200805-041HR – volume: 175 start-page: 6676 year: 2005 ident: 10.1016/j.ejpb.2023.01.013_b0435 article-title: Up-regulation of CC chemokine ligand 20 expression in human airway epithelium by IL-17 through a JAK-independent but MEK/NF-kappaB-dependent signaling pathway publication-title: J. Immunol. doi: 10.4049/jimmunol.175.10.6676 – volume: 229 start-page: 384 year: 2014 ident: 10.1016/j.ejpb.2023.01.013_b0365 article-title: Acrolein induced both pulmonary inflammation and the death of lung epithelial cells publication-title: Toxicol. Lett. doi: 10.1016/j.toxlet.2014.06.021 – volume: 28 start-page: 1273 year: 1998 ident: 10.1016/j.ejpb.2023.01.013_b0815 article-title: Cell lines of pulmonary and non-pulmonary origin as tools to study the effects of house dust mite proteinases on the regulation of epithelial permeability, Clinical and Experimental publication-title: Allergy – volume: 98 year: 2019 ident: 10.1016/j.ejpb.2023.01.013_b0755 article-title: In vitro model for predicting acute inhalation toxicity by using a Calu-3 epithelium cytotoxicity assay publication-title: J. Pharmacol. Toxicol. Methods doi: 10.1016/j.vascn.2019.04.002 – start-page: 402 year: 2008 ident: 10.1016/j.ejpb.2023.01.013_b0405 article-title: In vitro testing of inhalable fly ash at the air liquid interface (Eds.) publication-title: Advanced Environmental Monitoring. Springer doi: 10.1007/978-1-4020-6364-0_31 – volume: 532 start-page: 537 year: 2017 ident: 10.1016/j.ejpb.2023.01.013_b0645 article-title: A comprehensive screening platform for aerosolizable protein formulations for intranasal and pulmonary drug delivery publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2017.09.027 – volume: 107 start-page: 223 year: 2016 ident: 10.1016/j.ejpb.2023.01.013_b0630 article-title: Application of RPMI 2650 nasal cell model to a 3D printed apparatus for the testing of drug deposition and permeation of nasal products publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/j.ejpb.2016.07.010 – volume: 100 start-page: 681 year: 2011 ident: 10.1016/j.ejpb.2023.01.013_b0285 article-title: Poloxamer/cyclodextrin/chitosan-based thermoreversible gel for intranasal delivery of fexofenadine hydrochloride publication-title: J. Pharm. Sci. doi: 10.1002/jps.22314 – volume: 31 start-page: 738 year: 1995 ident: 10.1016/j.ejpb.2023.01.013_b0700 article-title: Tight Junctions and Mucin mRNA in BEAS-2B Cells publication-title: In Vitro Cell. Dev. Biol. doi: 10.1007/BF02634112 – volume: 104 start-page: 3029 year: 2015 ident: 10.1016/j.ejpb.2023.01.013_b0195 publication-title: J. Pharm. Sci. doi: 10.1002/jps.24381 – volume: 20 start-page: 63 year: 2020 ident: 10.1016/j.ejpb.2023.01.013_b0265 article-title: Expression and Clinical Significance of Mucin Gene in Chronic Rhinosinusitis publication-title: Curr. Allergy Asthma Rep. doi: 10.1007/s11882-020-00958-w – volume: 20 start-page: 545 year: 2003 ident: 10.1016/j.ejpb.2023.01.013_b0670 article-title: 16HBE14o- Human Bronchial Epithelial Cell Layers Express P-Glycoprotein, Lung Resistance-Related Protein, and Caveolin-1 publication-title: Pharm. Res. doi: 10.1023/A:1023230328687 – ident: 10.1016/j.ejpb.2023.01.013_b0485 doi: 10.3390/biom12091260 – volume: 44 start-page: 692 year: 2011 ident: 10.1016/j.ejpb.2023.01.013_b0440 article-title: Type I alveolar epithelial phenotype in primary culture publication-title: Am. J. Respir. Cell Mol. Biol. doi: 10.1165/rcmb.2009-0359OC – volume: 2 start-page: 68 year: 2013 ident: 10.1016/j.ejpb.2023.01.013_b0445 article-title: MUC1 expression by human airway epithelial cells mediates pseudomonas aeruginosa adhesion publication-title: Front. Biosci. (Elite Ed.) – volume: 64 start-page: 614 year: 2012 ident: 10.1016/j.ejpb.2023.01.013_b0080 article-title: Intranasal delivery of biologics to the central nervous system publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/j.addr.2011.11.002 – volume: 2013 start-page: 1 year: 2013 ident: 10.1016/j.ejpb.2023.01.013_b0855 article-title: Inflammatory and Oxidative Stress Responses of an Alveolar Epithelial Cell Line to Airborne Zinc Oxide Nanoparticles at the Air-Liquid Interface: A Comparison with Conventional, Submerged Cell-Culture Conditions publication-title: BioMed. Res. Int. doi: 10.1155/2013/652632 – volume: 46 start-page: 219 year: 2018 ident: 10.1016/j.ejpb.2023.01.013_b0360 article-title: Inflammatory effects of acrolein, crotonaldehyde and hexanal vapors on human primary bronchial epithelial cells cultured at air-liquid interface publication-title: Toxicol. In Vitro doi: 10.1016/j.tiv.2017.09.016 – volume: 590 start-page: 258 year: 2016 ident: 10.1016/j.ejpb.2023.01.013_b0840 article-title: Quantifying the magnitude of the oxygen artefact inherent in culturing airway cells under atmospheric oxygen versus physiological levels publication-title: FEBS Lett. doi: 10.1002/1873-3468.12026 – volume: 17 start-page: 136 year: 2020 ident: 10.1016/j.ejpb.2023.01.013_b0525 article-title: In vitro virucidal activity of Echinaforce(R), an Echinacea purpurea preparation, against coronaviruses, including common cold coronavirus 229E and SARS-CoV-2 publication-title: Virol. J. doi: 10.1186/s12985-020-01401-2 – volume: 299 start-page: L808 year: 2010 ident: 10.1016/j.ejpb.2023.01.013_b0370 article-title: LTD4 induces HB-EGF-dependent CXCL8 release through EGFR activation in human bronchial epithelial cells, American Journal of Physiology-Lung Cellular and Molecular publication-title: Physiology – volume: 46 start-page: 798 year: 1986 ident: 10.1016/j.ejpb.2023.01.013_b0895 article-title: Growth of Cell Lines and Clinical Specimens of Human Non-Small Cell Lung Cancer in a Serum-free Defined Medium publication-title: Cancer Res. – volume: 11 start-page: 995 year: 2014 ident: 10.1016/j.ejpb.2023.01.013_b0885 article-title: The cell line NCl-H441 is a useful in vitro model for transport studies of human distal lung epithelial barrier publication-title: Mol. Pharm. doi: 10.1021/mp4006535 – volume: 19 start-page: 30 year: 1998 ident: 10.1016/j.ejpb.2023.01.013_b0320 article-title: MUC5B and MUC7 Are Differentially Expressed in Mucous and Serous Cells of Submucosal Glands in Human Bronchial Airways publication-title: Am. J. Respir. Cell Mol. Biol. doi: 10.1165/ajrcmb.19.1.3054 – volume: 27 start-page: 1151 year: 2013 ident: 10.1016/j.ejpb.2023.01.013_b0500 article-title: Potential of in vitro reconstituted 3D human airway epithelia (MucilAir) to assess respiratory sensitizers publication-title: Toxicol. In Vitro doi: 10.1016/j.tiv.2012.10.010 – volume: 12 start-page: e0170428 year: 2017 ident: 10.1016/j.ejpb.2023.01.013_b0425 article-title: Development of Combining of Human Bronchial Mucosa Models with XposeALI(R) for Exposure of Air Pollution Nanoparticles publication-title: PLoS One doi: 10.1371/journal.pone.0170428 – volume: 12 year: 2020 ident: 10.1016/j.ejpb.2023.01.013_b0490 article-title: Comparison of Various Cell Lines and Three-Dimensional Mucociliary Tissue Model Systems to Estimate Drug Permeability Using an In Vitro Transport Study to Predict Nasal Drug Absorption in Rats publication-title: Pharmaceutics. doi: 10.3390/pharmaceutics12010079 – volume: 5 start-page: 1357 year: 2014 ident: 10.1016/j.ejpb.2023.01.013_b0860 article-title: Mimicking exposures to acute and lifetime concentrations of inhaled silver nanoparticles by two different in vitro approaches publication-title: Beilstein J. Nanotechnol. doi: 10.3762/bjnano.5.149 – volume: 2 start-page: 147 year: 2015 ident: 10.1016/j.ejpb.2023.01.013_b0305 article-title: Measurements of Functional Responses in Human Primary Lung Cells as a Basis for Personalized Therapy for Cystic Fibrosis publication-title: EBioMedicine doi: 10.1016/j.ebiom.2014.12.005 – volume: 48 start-page: 742 year: 2013 ident: 10.1016/j.ejpb.2023.01.013_b0450 article-title: Innate immune response of human alveolar type II cells infected with severe acute respiratory syndrome-coronavirus publication-title: Am. J. Respir. Cell Mol. Biol. doi: 10.1165/rcmb.2012-0339OC – start-page: 943 year: 2012 ident: 10.1016/j.ejpb.2023.01.013_b0350 article-title: Evaluation of differentiated human bronchial epithelial cell culture systems for asthma research publication-title: J Allergy (Cairo) – volume: 27 start-page: 164 year: 2013 ident: 10.1016/j.ejpb.2023.01.013_b0410 article-title: Validation of an in vitro exposure system for toxicity assessment of air-delivered nanomaterials publication-title: Toxicol. In Vitro doi: 10.1016/j.tiv.2012.08.030 – volume: 13 start-page: 37 year: 2017 ident: 10.1016/j.ejpb.2023.01.013_b0510 article-title: Protective barrier properties of Rhinosectan((R)) spray (containing xyloglucan) on an organotypic 3D airway tissue model (MucilAir): results of an in vitro study publication-title: Allergy Asthma Clin. Immunol. doi: 10.1186/s13223-017-0209-6 – volume: 29 start-page: 1720 year: 2015 ident: 10.1016/j.ejpb.2023.01.013_b0900 article-title: Evaluation of an air-liquid interface cell culture model for studies on the inflammatory and cytotoxic responses to tobacco smoke aerosols publication-title: Toxicol. In Vitro doi: 10.1016/j.tiv.2015.06.016 – volume: 10 start-page: 1837 year: 1997 ident: 10.1016/j.ejpb.2023.01.013_b0150 article-title: MDR1-Pgp 170 expression in human bronchus publication-title: Eur. Respir. J. doi: 10.1183/09031936.97.10081837 – volume: 7 start-page: e32924 year: 2012 ident: 10.1016/j.ejpb.2023.01.013_b0230 article-title: Comparison of nasal and bronchial epithelial cells obtained from patients with COPD publication-title: PLoS One doi: 10.1371/journal.pone.0032924 – volume: 328 start-page: 77 year: 2006 ident: 10.1016/j.ejpb.2023.01.013_b0155 article-title: P-glycoprotein (MDR1) functional activity in human alveolar epithelial cell monolayers, Cell and Tissue publication-title: Research – volume: 40 start-page: 1953 year: 2012 ident: 10.1016/j.ejpb.2023.01.013_b0710 article-title: Xenobiotic metabolism and disposition in human lung cell models: comparison with in vivo expression profiles publication-title: Drug Metab. Dispos. doi: 10.1124/dmd.112.046896 – volume: 10 year: 2013 ident: 10.1016/j.ejpb.2023.01.013_b0040 article-title: Growth of human bronchial epithelial cells at an air-liquid interface alters the response to particle exposure publication-title: Part. Fibre Toxicol. doi: 10.1186/1743-8977-10-25 – volume: 78 start-page: 19 year: 2011 ident: 10.1016/j.ejpb.2023.01.013_b0745 article-title: Calu-3 cells grown under AIC and LCC conditions: implications for dipeptide uptake and transepithelial transport of substances publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/j.ejpb.2010.12.030 – volume: 118 start-page: 68 year: 2017 ident: 10.1016/j.ejpb.2023.01.013_b0480 article-title: Establishment and characterization of an in vitro human small airway model (SmallAir) publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/j.ejpb.2016.12.006 – volume: 47 start-page: 9 year: 2019 ident: 10.1016/j.ejpb.2023.01.013_b0520 article-title: Short-term and Long-term Exposure of the MucilAir Model to Polycyclic Aromatic Hydrocarbons publication-title: Altern. Lab. Anim. doi: 10.1177/0261192919841484 – volume: 14 start-page: 1577 year: 2017 ident: 10.1016/j.ejpb.2023.01.013_b0170 article-title: Activity of Multidrug Resistance-Associated Proteins 1–5 (MRP1−5) in the RPMI 2650 Cell Line and Explants of Human Nasal Turbinate publication-title: Mol. Pharm. doi: 10.1021/acs.molpharmaceut.6b00838 – volume: 11 start-page: 1467 year: 2011 ident: 10.1016/j.ejpb.2023.01.013_b0225 article-title: Tissue-Specific stem cell differentiation in an in vitro airway model publication-title: Macromol. Biosci. doi: 10.1002/mabi.201100181 – volume: 8 start-page: 168 year: 2018 ident: 10.1016/j.ejpb.2023.01.013_b0640 article-title: Enhanced nasal drug delivery efficiency by increasing mechanical loading using hypergravity publication-title: Sci. Rep. doi: 10.1038/s41598-017-18561-x – volume: 25 start-page: 196 year: 2001 ident: 10.1016/j.ejpb.2023.01.013_b0765 article-title: Antibacterial Activity of Apical Surface Fluid from the Human Airway Cell Line Calu-3 publication-title: Am. J. Respir. Cell Mol. Biol. doi: 10.1165/ajrcmb.25.2.4211 – volume: 23 start-page: 1482 year: 2006 ident: 10.1016/j.ejpb.2023.01.013_b0740 article-title: Culture of Calu-3 cells at the air interface provides a representative model of the airway epithelial barrier publication-title: Pharm. Res. doi: 10.1007/s11095-006-0255-0 – volume: 426 start-page: 7 year: 2012 ident: 10.1016/j.ejpb.2023.01.013_b0735 article-title: Evaluation of air-interfaced Calu-3 cell layers for investigation of inhaled drug interactions with organic cation transporters in vitro publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2011.12.036 |
| SSID | ssj0004758 |
| Score | 2.626292 |
| SecondaryResourceType | review_article |
| Snippet | [Display omitted]
The intranasal route has been receiving greater attention from the scientific community not only for systemic drug delivery but also for the... The intranasal route has been receiving greater attention from the scientific community not only for systemic drug delivery but also for the treatment of... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 62 |
| SubjectTerms | Air-liquid interface Airway epithelium Cell lines Intranasal administration Primary cells Pulmonary administration |
| Title | Air-liquid interface (ALI) impact on different respiratory cell cultures |
| URI | https://dx.doi.org/10.1016/j.ejpb.2023.01.013 https://www.ncbi.nlm.nih.gov/pubmed/36696943 https://www.proquest.com/docview/2769993415 |
| Volume | 184 |
| WOSCitedRecordID | wos000964928800001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1873-3441 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0004758 issn: 0939-6411 databaseCode: AIEXJ dateStart: 19970101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1ba9swFBZpu4e9jN2XXYoGI2ykDo0tW9Jj2BLaErLA0pE3I8syc_CcNDfa37A_vSNLttOtLd3DIJhYWLbR9_no6OhcEPoQwdoYZtIEEPClQxIeOMyXxFFdGblBFEW88Cb8PqSjEZtO-bjR-FXGwmwzmufs8pIv_ivU0AZg69DZf4C7uik0wH8AHY4AOxzvBXwvXTpZerFJ4yIXxDIRstAje8NTbQIowyLzqjbKur3c2W_Xlvy2ycdh3QtvsttbHXbxo7aIm2TPUTq_1lhZcNJsW-ip34BzaW0FSEu3jrO5yKvmgchksYXvmSicn8XJl0yKypd4vTHRbD3by1ouXK923bLCllHP8YhJfNVRN7RVEprsyFgjvf8S_cYKMeuo2SLq6McV6VhNoOv1PNujr-HgfDgMJ_3ppLW4cHQJMr1Vb-ux7KEDl_ocRORB77Q_PavDbGlR7rV6RRuDZdwF_3zsbXrObeuYQp-ZPEaP7EIE9wyBnqCGyp-i1thgd3WEJ3Vg3uoIt_C4znF-9Qyd1CzDFcvwR-DYJ2wYhuc5rhiGdxiGNcNwybDn6HzQn3w-cWxRDkeCuF875DiOmPBZlzLpyYQxFtMo9nylFBWBruKiBA2khNkidiOXKxIT4hLKeOJKXYfkBdrP57l6hTBoilwEie_5XBJPcCFgtnFjuJGfuFTwJuqWQxhKm7FeF07JwtI1cRbqYQ_1sIfHXfh5TdSu-ixMvpY7r_ZLZEKrcRpNMgRW3dnvfQljCOJYj5vI1XyzCl0awJILVEO_iV4afKv38IKAB5x4r-_R-w16WH8yb9H-erlR79ADuV2nq-Uh2qNTdmj5-RtSebRI |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Air-liquid+interface+%28ALI%29+impact+on+different+respiratory+cell+cultures&rft.jtitle=European+journal+of+pharmaceutics+and+biopharmaceutics&rft.au=Silva%2C+Soraia&rft.au=Bicker%2C+Joana&rft.au=Falc%C3%A3o%2C+Am%C3%ADlcar&rft.au=tuna%2C+Ana&rft.date=2023-03-01&rft.issn=1873-3441&rft.eissn=1873-3441&rft.volume=184&rft.spage=62&rft_id=info:doi/10.1016%2Fj.ejpb.2023.01.013&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0939-6411&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0939-6411&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0939-6411&client=summon |