Intrinsic immunogenicity of liposomes for tuberculosis vaccines: Effect of cationic lipid and cholesterol

Tuberculosis (TB) is still among the deadliest infectious diseases, hence there is a pressing need for more effective TB vaccines. Cationic liposome subunit vaccines are excellent vaccine candidates offering effective protection with a better safety profile than live vaccines. In this study, we aim...

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Bibliographic Details
Published in:	European journal of pharmaceutical sciences Vol. 195; p. 106730
Main Authors:	Szachniewicz, M.M., Neustrup, M.A., van Meijgaarden, K.E., Jiskoot, W., Bouwstra, J.A., Haks, M.C., Geluk, A., Ottenhoff, T.H.M.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.04.2024
Subjects:	Adjuvant Adjuvants, Immunologic - chemistry Animals Cationic liposome Cholesterol Cholesterol - chemistry Dendritic cells Humans Immunogenicity Lipids - chemistry Liposomes - chemistry Mice Mice, Inbred C57BL Tuberculosis Tuberculosis Vaccines - chemistry Vaccines Vaccines, Subunit DDA CXCL M-CSF DC-cholesterol Cationic liposome TNF DODMA SA IFN PDI GM-CSF FBS Adjuvant CCR7 Th1 DOPC CD DSPC GL-67 Dendritic cells BCG MACS IQR CCL PBMC Cholesterol AER TB PAMP MDDC Tuberculosis Immunogenicity APC MVL5 EPC Mtb DOTAP HLA Ig DC
ISSN:	0928-0987, 1879-0720, 1879-0720
Online Access:	Get full text
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