BNIP3 as a progression marker in primary human breast cancer; opposing functions in in situ versus invasive cancer

BNIP3 is involved in cell death and cell survival via autophagy. Its perinecrotic localization within ductal carcinoma in situ (DCIS) suggests an involvement in neoplastic cellular adaptation to low oxygen tension. This study has investigated the role of BNIP3 in normal and neoplastic breast. Whole...

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Veröffentlicht in:	Clinical cancer research Jg. 13; H. 2 Pt 1; S. 467
Hauptverfasser:	Tan, Ern Yu, Campo, Leticia, Han, Cheng, Turley, Helen, Pezzella, Francesco, Gatter, Kevin C, Harris, Adrian L, Fox, Stephen B
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 15.01.2007
Schlagworte:	Adult Aged Aged, 80 and over Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinoma, Intraductal, Noninfiltrating - genetics Carcinoma, Intraductal, Noninfiltrating - metabolism Carcinoma, Intraductal, Noninfiltrating - pathology Cytoplasm - metabolism Disease Progression Disease-Free Survival Female Gene Expression Regulation, Neoplastic Humans Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis Membrane Proteins - biosynthesis Membrane Proteins - physiology Middle Aged Neoplasm Invasiveness Proportional Hazards Models Proto-Oncogene Proteins - biosynthesis Proto-Oncogene Proteins - physiology Treatment Outcome Up-Regulation
ISSN:	1078-0432
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