Integrin αvβ6 critically regulates hepatic progenitor cell function and promotes ductular reaction, fibrosis, and tumorigenesis

Integrin αvβ6 is rapidly up‐regulated on cells of epithelial lineage during tissue injury, where one of its primary functions is activation of latent transforming growth factor beta 1 (TGFβ1). In human liver cirrhosis, αvβ6 is overexpressed by cells comprising the ductular reaction, and its inhibiti...

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Bibliographic Details

Published in:	Hepatology (Baltimore, Md.) Vol. 63; no. 1; pp. 217 - 232
Main Authors:	Peng, Zhen‐Wei, Ikenaga, Naoki, Liu, Susan B., Sverdlov, Deanna Y., Vaid, Kahini A., Dixit, Richa, Weinreb, Paul H., Violette, Shelia, Sheppard, Dean, Schuppan, Detlef, Popov, Yury
Format:	Journal Article
Language:	English
Published:	United States 01.01.2016
Subjects:	Animals Antigens, Neoplasm - physiology Carcinogenesis Cholangitis, Sclerosing - etiology Fibrosis - etiology Hepatocytes Humans Integrins - physiology Liver - pathology Liver Cirrhosis - etiology Liver Neoplasms - etiology Male Mice Mice, Inbred C57BL Stem Cells - physiology
ISSN:	0270-9139, 1527-3350
Online Access:	Get full text
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