High levels of hemolysis do not affect measurement of PAPP-A, β-HCG and TRAb on BRAHMS KRYPTOR compact plus
To assess the impact of high levels of hemolysis on the laboratory results for free β-hCG, PAPP-A, and TRAb performed on the B·R·A·H·M·S KRYPTOR Compact PLUS. Adapted from the CLSI guidelines EP07-A2, paired difference testing was performed on serum samples from the routine laboratory workflow. Thre...
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| Veröffentlicht in: | Scandinavian journal of clinical and laboratory investigation Jg. ahead-of-print; H. ahead-of-print; S. 1 - 4 |
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Taylor & Francis
03.10.2023
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| ISSN: | 0036-5513, 1502-7686, 1502-7686 |
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| Abstract | To assess the impact of high levels of hemolysis on the laboratory results for free β-hCG, PAPP-A, and TRAb performed on the B·R·A·H·M·S KRYPTOR Compact PLUS. Adapted from the CLSI guidelines EP07-A2, paired difference testing was performed on serum samples from the routine laboratory workflow. Three sample pools for each assessed analyte was prepared and subjected to increased levels of added hemolysate. For β-hCG and PAPP-A, the relative difference in the measured analyte concentration between the sample with 0 g/L added Hb and the samples with increasing free Hb concentrations (up to 6 g/L), was well below the pre-set acceptance criterion of 10% at all levels. The TRAb results showed greater variation than the other analytes, likely a consequence of imprecision rather than hemolysis. Hemolysis has a negligible effect on the analysis results of free beta-hCG, PAPP-A and TRAb measured on the B·R·A·H·M·S KRYPTOR Compact PLUS. |
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| AbstractList | To assess the impact of high levels of hemolysis on the laboratory results for free β-hCG, PAPP-A, and TRAb performed on the B·R·A·H·M·S KRYPTOR Compact PLUS. Adapted from the CLSI guidelines EP07-A2, paired difference testing was performed on serum samples from the routine laboratory workflow. Three sample pools for each assessed analyte was prepared and subjected to increased levels of added hemolysate. For β-hCG and PAPP-A, the relative difference in the measured analyte concentration between the sample with 0 g/L added Hb and the samples with increasing free Hb concentrations (up to 6 g/L), was well below the pre-set acceptance criterion of 10% at all levels. The TRAb results showed greater variation than the other analytes, likely a consequence of imprecision rather than hemolysis. Hemolysis has a negligible effect on the analysis results of free beta-hCG, PAPP-A and TRAb measured on the B·R·A·H·M·S KRYPTOR Compact PLUS.To assess the impact of high levels of hemolysis on the laboratory results for free β-hCG, PAPP-A, and TRAb performed on the B·R·A·H·M·S KRYPTOR Compact PLUS. Adapted from the CLSI guidelines EP07-A2, paired difference testing was performed on serum samples from the routine laboratory workflow. Three sample pools for each assessed analyte was prepared and subjected to increased levels of added hemolysate. For β-hCG and PAPP-A, the relative difference in the measured analyte concentration between the sample with 0 g/L added Hb and the samples with increasing free Hb concentrations (up to 6 g/L), was well below the pre-set acceptance criterion of 10% at all levels. The TRAb results showed greater variation than the other analytes, likely a consequence of imprecision rather than hemolysis. Hemolysis has a negligible effect on the analysis results of free beta-hCG, PAPP-A and TRAb measured on the B·R·A·H·M·S KRYPTOR Compact PLUS. To assess the impact of high levels of hemolysis on the laboratory results for free β-hCG, PAPP-A, and TRAb performed on the B·R·A·H·M·S KRYPTOR Compact PLUS. Adapted from the CLSI guidelines EP07-A2, paired difference testing was performed on serum samples from the routine laboratory workflow. Three sample pools for each assessed analyte was prepared and subjected to increased levels of added hemolysate. For β-hCG and PAPP-A, the relative difference in the measured analyte concentration between the sample with 0 g/L added Hb and the samples with increasing free Hb concentrations (up to 6 g/L), was well below the pre-set acceptance criterion of 10% at all levels. The TRAb results showed greater variation than the other analytes, likely a consequence of imprecision rather than hemolysis. Hemolysis has a negligible effect on the analysis results of free beta-hCG, PAPP-A and TRAb measured on the B·R·A·H·M·S KRYPTOR Compact PLUS. |
| Author | Pettersson Pablo, Paul Aneskans, Cecilia Vink, Martin |
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| Cites_doi | 10.1002/anie.198702661 10.1093/clinchem/46.2.306 10.1016/s1389-0352(01)00040-x 10.1515/cclm-2017-1104 10.1016/j.preghy.2017.12.009 10.1007/s10895-005-2829-3 10.3343/alm.2022.42.2.169 10.1515/cclm-2022-0924 |
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| Keywords | TSH receptor antibody beta subunit fluoroimmunoassay Chorionic gonadotropin pregnancy-associated plasma protein-A human hemolysis |
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| References | McEnroe RJ (e_1_3_3_16_1) Jones BA (e_1_3_3_3_1) 1997; 121 Thomas L. (e_1_3_3_2_1) 2002; 13 e_1_3_3_9_1 e_1_3_3_8_1 Greenson JK (e_1_3_3_6_1) 1989; 113 e_1_3_3_18_1 e_1_3_3_17_1 e_1_3_3_14_1 e_1_3_3_13_1 Grafmeyer D (e_1_3_3_7_1) 1995; 33 e_1_3_3_10_1 McCaughey EJ (e_1_3_3_15_1) 2016; 37 e_1_3_3_5_1 e_1_3_3_12_1 e_1_3_3_4_1 e_1_3_3_11_1 |
| References_xml | – volume: 113 start-page: 184 issue: 2 year: 1989 ident: e_1_3_3_6_1 article-title: The effect of hemolysis on creatine kinase determination publication-title: Arch Pathol Lab Med – ident: e_1_3_3_10_1 doi: 10.1002/anie.198702661 – ident: e_1_3_3_4_1 doi: 10.1093/clinchem/46.2.306 – ident: e_1_3_3_12_1 – ident: e_1_3_3_11_1 doi: 10.1016/s1389-0352(01)00040-x – volume: 121 start-page: 19 issue: 1 year: 1997 ident: e_1_3_3_3_1 article-title: Chemistry specimen acceptability: a college of American pathologists Q-Probes study of 453 laboratories publication-title: Arch Pathol Lab Med – volume-title: Wayne, PA: Clinical and Laboratory Standards Institute; 2005 ident: e_1_3_3_16_1 – volume: 37 start-page: 143 issue: 4 year: 2016 ident: e_1_3_3_15_1 article-title: Current methods of haemolysis detection and reporting as a source of risk to patient safety: a narrative review publication-title: Clin Biochem Rev – volume: 13 start-page: 95 issue: 4 year: 2002 ident: e_1_3_3_2_1 article-title: Haemolysis as influence & interference factor publication-title: EJIFCC – ident: e_1_3_3_5_1 doi: 10.1515/cclm-2017-1104 – ident: e_1_3_3_9_1 doi: 10.1016/j.preghy.2017.12.009 – ident: e_1_3_3_8_1 doi: 10.1007/s10895-005-2829-3 – ident: e_1_3_3_13_1 – ident: e_1_3_3_17_1 doi: 10.3343/alm.2022.42.2.169 – volume: 33 start-page: 31 issue: 1 year: 1995 ident: e_1_3_3_7_1 article-title: The influence of bilirubin, haemolysis and turbidity on 20 analytical tests performed on automatic analysers. Results of an interlaboratory study publication-title: Eur J Clin Chem Clin Biochem – ident: e_1_3_3_14_1 – ident: e_1_3_3_18_1 doi: 10.1515/cclm-2022-0924 |
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| SubjectTerms | beta subunit Chorionic gonadotropin fluoroimmunoassay hemolysis human pregnancy-associated plasma protein-A TSH receptor antibody |
| Title | High levels of hemolysis do not affect measurement of PAPP-A, β-HCG and TRAb on BRAHMS KRYPTOR compact plus |
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