Targeting PLK1 as a novel chemopreventive approach to eradicate preneoplastic mucosal changes in the head and neck

Head and neck squamous cell carcinomas (HNSCC) and local relapses thereof develop in preneoplastic fields in the mucosal linings of the upper aerodigestive tract. These fields are characterized by tumor-associated genetic changes, are frequently dysplastic and occasionally macroscopically visible. C...

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Vydané v:	Oncotarget Ročník 8; číslo 58; s. 97928
Hlavní autori:	de Boer, D Vicky, Martens-de Kemp, Sanne R, Buijze, Marijke, Stigter-van Walsum, Marijke, Bloemena, Elisabeth, Dietrich, Ralf, Leemans, C René, van Beusechem, Victor W, Braakhuis, Boudewijn J M, Brakenhoff, Ruud H
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 17.11.2017
Predmet:	polo-like kinase 1 siRNA screening preneoplastic fields head and neck squamous cell carcinoma targeted treatment
ISSN:	1949-2553, 1949-2553
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