Recent advances on magnetic nanobead based biosensors: From separation to detection

Magnetic nanobeads have been widely used for magnetic separation, target labeling and signal amplification in the development of various biosensors. This review summarized (1) the basic knowledge of magnetic nanobeads, including physical structure, chemical characteristics and surface modification;...

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Veröffentlicht in:TrAC, Trends in analytical chemistry (Regular ed.) Jg. 128; S. 115915
Hauptverfasser: Wang, Lei, Lin, Jianhan
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Elsevier B.V 01.07.2020
Schlagworte:
analytical chemistry
biosensors
Electrochemical biosensor
Electromagnetic biosensor
High gradient magnetic separation
Magnetic continuous-flow separation
Magnetic grid separation
Magnetic lateral flow biosensor
Magnetic relaxation switching biosensor
magnetic separation
magnetism
Magnetophoretic separation
QCM biosensor
SPR biosensor
QCM biosensor
Magnetic relaxation switching biosensor
High gradient magnetic separation
Magnetophoretic separation
Electromagnetic biosensor
Magnetic grid separation
SPR biosensor
Magnetic lateral flow biosensor
Electrochemical biosensor
Magnetic continuous-flow separation
ISSN:0165-9936, 1879-3142
Online-Zugang:Volltext
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Zusammenfassung:Magnetic nanobeads have been widely used for magnetic separation, target labeling and signal amplification in the development of various biosensors. This review summarized (1) the basic knowledge of magnetic nanobeads, including physical structure, chemical characteristics and surface modification; (2) the development and applications of magnetic separation, from the earliest conventional magnetic separation, to high gradient magnetic separation, then to magnetophoretic separation and magnetic continuous-flow separation, finally to the latest magnetic grid separation; and (3) recent advances and applications of magnetic nanobead based biosensors, where the magnetic nanobeads work as either detection signal for electromagnetic biosensors, magnetic lateral flow biosensors and magnetic relaxation switching biosensors, or signal amplifying tag for electrochemical biosensors, QCM biosensors and SPR biosensors, or both. Besides, the important issues and future trends for magnetic nanobead based separation and biosensor were also discussed and summarized. •Basic knowledge of magnetic nanobeads were summarized.•Recent advances on MNBs for magnetic separation were reviewed.•Recent advances on MNBs for target label were reviewed.•Recent advances on MNBs for signal amplification were reviewed.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0165-9936
1879-3142
DOI:10.1016/j.trac.2020.115915