Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase and epidemiologic patterns of pyrimethamine-sulfadoxine use and resistance

To assess the relationship between mutations in Plasmodium falciparum dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) and clinical pyrimethamine-sulfadoxine resistance, polymerase chain reaction surveys and analyses for new mutations were conducted in four countries with increasin...

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Bibliographic Details
Published in:	The Journal of infectious diseases Vol. 176; no. 6; p. 1590
Main Authors:	Plowe, C V, Cortese, J F, Djimde, A, Nwanyanwu, O C, Watkins, W M, Winstanley, P A, Estrada-Franco, J G, Mollinedo, R E, Avila, J C, Cespedes, J L, Carter, D, Doumbo, O K
Format:	Journal Article
Language:	English
Published:	United States 01.12.1997
Subjects:	Africa - epidemiology Amino Acid Sequence Animals Antimalarials - pharmacology Antimalarials - therapeutic use Base Sequence Bolivia - epidemiology Cloning, Molecular Dihydropteroate Synthase - genetics Dihydropteroate Synthase - metabolism DNA, Protozoan - analysis DNA, Protozoan - genetics Drug Combinations Drug Resistance Humans Malaria, Falciparum - drug therapy Malaria, Falciparum - epidemiology Malaria, Falciparum - genetics Malaria, Falciparum - parasitology Molecular Epidemiology Molecular Sequence Data Molecular Structure Mutagenesis, Insertional Plasmodium falciparum - drug effects Plasmodium falciparum - enzymology Plasmodium falciparum - genetics Point Mutation Polymerase Chain Reaction Prevalence Pyrimethamine - pharmacology Pyrimethamine - therapeutic use Sulfadoxine - pharmacology Sulfadoxine - therapeutic use Tetrahydrofolate Dehydrogenase - chemistry Tetrahydrofolate Dehydrogenase - genetics Tetrahydrofolate Dehydrogenase - metabolism Bolivia Africa
ISSN:	0022-1899
Online Access:	Get more information
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