Mixed radiation with different doses induces CCL17 to recruit CD8+T cell to exert anti-tumor effects in non-small cell lung cancer

Different doses of radiotherapy (RT) exert diverse effects on tumor immunity, although the precise irradiation method remains unknown. This study sought to elucidate the influence of combining different doses of RT with immune checkpoint inhibitors (ICIs) on the infiltration of CD8 T cells within tu...

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Veröffentlicht in:	Frontiers in immunology Jg. 15; S. 1508007
Hauptverfasser:	Huang, Liuying, Wang, Duo, Xu, Muchen, Qian, Danqi, Cao, Yulin, Wu, Xiaohan, Ming, Liang, Tang, Junhui, Huang, Zhaohui, Yin, Yuan, Zhou, Leyuan
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland Frontiers Media S.A 14.01.2025
Schlagworte:	animal research Animals Carcinoma, Non-Small-Cell Lung - immunology Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - radiotherapy Carcinoma, Non-Small-Cell Lung - therapy CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - radiation effects Cell Line, Tumor Chemokine CCL17 - genetics Chemokine CCL17 - immunology Chemokine CCL17 - metabolism combination therapy Disease Models, Animal Dose-Response Relationship, Radiation Female Humans Immune Checkpoint Inhibitors - pharmacology Immunology immunotherapy lung cancer Lung Neoplasms - immunology Lung Neoplasms - metabolism Lung Neoplasms - pathology Lung Neoplasms - radiotherapy Lung Neoplasms - therapy Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - metabolism Lymphocytes, Tumor-Infiltrating - radiation effects Mice Mice, Inbred C57BL radiotherapy lung cancer radiotherapy combination therapy animal research immunotherapy
ISSN:	1664-3224, 1664-3224
Online-Zugang:	Volltext
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