Serpin E2 promotes breast cancer metastasis by remodeling the tumor matrix and polarizing tumor associated macrophages

The extracellular serine protease inhibitor serpinE2 is overexpressed in breast cancer and has been shown to foster metastatic spread. Here, we investigated the hypothesis that serpinE2 creates tumor-promoting conditions in the tumor microenvironment (TME) by affecting extracellular matrix remodelin...

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Veröffentlicht in:	Oncotarget Jg. 7; H. 50; S. 82289
Hauptverfasser:	Smirnova, Tatiana, Bonapace, Laura, MacDonald, Gwen, Kondo, Shunya, Wyckoff, Jeffrey, Ebersbach, Hilmar, Fayard, Bérengère, Doelemeyer, Arno, Coissieux, Marie-May, Heideman, Marinus R, Bentires-Alj, Mohamed, Hynes, Nancy E
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 13.12.2016
Schlagworte:	Animals Antineoplastic Agents - pharmacology Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Cell Movement - drug effects Chemokine CCL2 - metabolism Collagen Type I - metabolism Extracellular Matrix - metabolism Extracellular Matrix - pathology Extracellular Signal-Regulated MAP Kinases - metabolism Female Humans Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - prevention & control Lung Neoplasms - secondary Macrophages - drug effects Macrophages - metabolism Macrophages - pathology Mice, Inbred BALB C Mice, SCID Neoplasm Invasiveness Phenotype RNA Interference Serpin E2 - antagonists & inhibitors Serpin E2 - genetics Serpin E2 - metabolism Signal Transduction Tissue Inhibitor of Metalloproteinase-1 - metabolism Transfection Tumor Microenvironment Xenograft Model Antitumor Assays tumor associated macrophages breast cancer serine protease inhibitors metastasis collagen I
ISSN:	1949-2553, 1949-2553
Online-Zugang:	Weitere Angaben
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