Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders

A sensitive immunohistochemical method for phosphorylated α-synuclein was used to stain sets of sections of spinal cord and tissue from 41 different sites in the bodies of 92 subjects, including 23 normal elderly, 7 with incidental Lewy body disease (ILBD), 17 with Parkinson’s disease (PD), 9 with d...

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Bibliographic Details
Published in:	Acta neuropathologica Vol. 119; no. 6; pp. 689 - 702
Main Authors:	Beach, Thomas G., Adler, Charles H., Sue, Lucia I., Vedders, Linda, Lue, LihFen, White III, Charles L., Akiyama, Haru, Caviness, John N., Shill, Holly A., Sabbagh, Marwan N., Walker, Douglas G.
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer-Verlag 01.06.2010
Subjects:	Aged Aged, 80 and over alpha-Synuclein - metabolism Alzheimer Disease - metabolism Alzheimer Disease - pathology Brain - metabolism Brain - pathology Female Ganglia, Sympathetic - metabolism Ganglia, Sympathetic - pathology Gastrointestinal Tract - metabolism Gastrointestinal Tract - pathology Humans Immunohistochemistry Lewy Body Disease - metabolism Lewy Body Disease - pathology Male Medicine Medicine & Public Health Neurosciences Original Paper Parkinson Disease - metabolism Parkinson Disease - pathology Pathology Peripheral Nervous System - metabolism Peripheral Nervous System - pathology Phosphorylation Spinal Cord - metabolism Spinal Cord - pathology Peripheral nervous system Heart α-Synuclein Stomach Spinal cord Alzheimer’s disease Submandibular gland Sympathetic nervous system Esophagus Parkinsonism Enteric nervous system Autonomic nervous system Gastrointestinal system Adrenal gland Parkinson’s disease Incidental Lewy bodies Dementia with Lewy bodies
ISSN:	0001-6322, 1432-0533, 1432-0533
Online Access:	Get full text
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