Mycotoxins, invisible danger of feedstuff with toxic effect on animals

Mycotoxins are low-molecular weight compounds produced mainly by fungi, with Fusarium and Aspergillus origin. Secondary, metabolites, are mostly found on plants. However, the contamination of the feed and forage has been also reported. Because of their pharmacological activity, mycotoxins can be use...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Toxicon (Oxford) Jg. 182; S. 34 - 53
1. Verfasser: Buszewska-Forajta, Magdalena
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Elsevier Ltd 30.07.2020
Schlagworte:
Aflatoxins
Animals
Aspergillus
chronic exposure
Detoxification
DNA
estrogenic properties
feeds
forage
Forage contamination
Fumonisin
fumonisins
Fusarium
medicinal properties
metabolism
metabolites
Methods of mycotoxins determination
mutagens
Mycotoxins
neutralization
ochratoxins
toxicity
trichothecenes
Zearaelonone trichothecens
zearalenone
Aflatoxins
Animals
Forage contamination
Mycotoxins
Zearaelonone trichothecens
Detoxification
Fumonisin
Methods of mycotoxins determination
ISSN:0041-0101, 1879-3150, 1879-3150
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Mycotoxins are low-molecular weight compounds produced mainly by fungi, with Fusarium and Aspergillus origin. Secondary, metabolites, are mostly found on plants. However, the contamination of the feed and forage has been also reported. Because of their pharmacological activity, mycotoxins can be used as chemical warfare agents, drugs or growth promotants. Additionally, mycotoxins are found as one of the most dangerous genotoxic factors which cause the damage of DNA and lead to disease development. This review includes the knowledge of mycotoxins as both, an invisible danger of forage and as food additives. Special emphasis shall be given on mycotoxins with proven cancerogenic activity; including aflatoxins, fumonisins, ochratoxins, trichothecenes, and zearalenone. Factors such as species, mechanisms/modes of action, metabolism, and defense mechanisms were taken into account. The main concern was focused on zearalenone characterization, because of its estrogenic activity, caused by structural similarity to estrogens, naturally occurring in cells. By binding to estrogenic receptors, toxins are, accumulated in organisms and long-term exposure may cause the disturbances, especially in the reproductive system. The next part of this paper contains the description of main strategies of toxins determination. Finally, in the review, several potential methods for the dioxins neutralization were discussed. •Characteristic of mycotoxins with proved cancerogenetic activity.•Main strategies for the determination of toxins with fungi origin.•Potential methods for neutralization of mycotoxins.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:0041-0101
1879-3150
1879-3150
DOI:10.1016/j.toxicon.2020.04.101