Functional exosome-mimic for delivery of siRNA to cancer: in vitro and in vivo evaluation

Exosomes, the smallest subgroup of extracellular vesicles, have been recognized as extracellular organelles that contain genetic and proteomic information for long distance intercellular communication. Exosome-based drug delivery is currently a subject of intensive research. Here, we report a novel...

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Veröffentlicht in:	Journal of controlled release Jg. 243; S. 160 - 171
Hauptverfasser:	Yang, Zhaogang, Xie, Jing, Zhu, Jing, Kang, Chen, Chiang, Chiling, Wang, Xinmei, Wang, Xiaobing, Kuang, Tairong, Chen, Feng, Chen, Zhou, Zhang, Aili, Yu, Bo, Lee, Robert J., Teng, Lesheng, Lee, L. James
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 10.12.2016
Schlagworte:	Animals biosafety Breast Neoplasms - genetics cell communication Cell Line, Tumor drugs Electroporation Endocytosis Endocytosis - physiology Epithelial Cells - metabolism epithelium Exosome Exosomes extrusion filters gene transfer Gene Transfer Techniques Humans in vivo studies MCF-7 MCF-7 Cells Mice Mice, Inbred BALB C Mice, Nude neoplasms Particle Size proteomics RNA, Small Interfering - administration & dosage siRNA small interfering RNA Electroporation Endocytosis siRNA Exosome MCF-7
ISSN:	0168-3659, 1873-4995
Online-Zugang:	Volltext
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