Spectrum of Germline Pathogenic Variants in BRCA1/2 Genes in the Apulian Southern Italy Population: Geographic Distribution and Evidence for Targeted Genetic Testing

BRCA1/2-associated hereditary breast and ovarian cancer is the most common form of hereditary breast and ovarian cancer and occurs in all ethnicities and racial populations. Different BRCA1/BRCA2 pathogenic variants (PVs) have been reported with a wide variety among populations. In this study, we re...

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Veröffentlicht in:	Cancers Jg. 13; H. 18; S. 4714
Hauptverfasser:	Patruno, Margherita, De Summa, Simona, Resta, Nicoletta, Caputo, Mariapia, Costanzo, Silvia, Digennaro, Maria, Pilato, Brunella, Bagnulo, Rosanna, Pantaleo, Antonino, Simone, Cristiano, Natalicchio, Maria Iole, De Matteis, Elisabetta, Tarantino, Paolo, Tommasi, Stefania, Paradiso, Angelo
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Basel MDPI AG 21.09.2021 MDPI
Schlagworte:	Age BRCA1 protein BRCA2 protein Breast cancer Data collection Founder effect Genes Genetic screening Genotypes Geographical distribution Males Mutation Ovarian cancer Patients Phenotypes Population Population studies Tumors Italy Apulia Italy
ISSN:	2072-6694, 2072-6694
Online-Zugang:	Volltext
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