Composites of yeast glucan particles and curcumin lead to improvement of dextran sulfate sodium-induced acute bowel inflammation in rats

[Display omitted] •Glucan particles with loaded curcumin were used to treat bowel inflammation in vivo.•Prepared composites were analysed by microscopy techniques and by XRD analysis.•Glucan particles with incorporated curcumin were able to relieve symptoms of colitis.•Prepared composites decrease t...

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Vydáno v:Carbohydrate polymers Ročník 252; s. 117142
Hlavní autoři: Rotrekl, Dominik, Šalamúnová, Petra, Paráková, Lenka, Baďo, Ondrej, Saloň, Ivan, Štěpánek, František, Hanuš, Jaroslav, Hošek, Jan
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Elsevier Ltd 15.01.2021
Témata:
Animals
anti-inflammatory activity
Anti-Inflammatory Agents - administration & dosage
Anti-Inflammatory Agents - therapeutic use
catalase
colitis
Colitis - chemically induced
Colitis - drug therapy
Colitis targeting
Curcumin
Curcumin - administration & dosage
Curcumin - therapeutic use
Cytokines - metabolism
Dextran Sulfate
digestive system
Drug Carriers - therapeutic use
gelatinase B
Glucans - administration & dosage
Glucans - therapeutic use
Inflammation
interleukin-10
interleukin-17
interleukin-6
Interleukins - metabolism
Male
myeloperoxidase
Rats
Rats, Wistar
Saccharomyces cerevisiae - metabolism
superoxide dismutase
Yeast glucan particles
yeasts
β-Glucan
Colitis targeting
CD
DSS
IBD
Inflammation
GPs
MPO
PVDF
DAI
UC
NF-κB
Yeast glucan particles
TNF-α
CAT
TGF-β1
SEM
Curcumin
SOD-2
β-Glucan
MMP-9
ISSN:0144-8617, 1879-1344, 1879-1344
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Shrnutí:[Display omitted] •Glucan particles with loaded curcumin were used to treat bowel inflammation in vivo.•Prepared composites were analysed by microscopy techniques and by XRD analysis.•Glucan particles with incorporated curcumin were able to relieve symptoms of colitis.•Prepared composites decrease the level of pro-inflammatory cytokines and enzymes. The goal of this work was to assess the usability of yeast glucan particles (GPs) as carriers for curcumin and determine the beneficial effect of a pharmacological composite of curcumin in GPs on dextran sulfate sodium induced colitis in rats. The assessment of the anti-inflammatory effect of particular substances was evaluated on the basis of the calculated disease activity index and by assessment of cytokines and enzymes from the gut tissue – tumor necrosis factor α (TNF-α), transforming growth factor β1, interleukin (IL)-1β, IL-6, IL-10, IL-17, catalase, superoxide dismutase 2, myeloperoxidase (MPO), and matrix metalloproteinase 9. Composites of GPs with incorporated curcumin showed promising results with the capability to lower symptoms of colitis and significantly decrease the production of pro-inflammatory cytokines TNF-α, IL-1β, IL-6, and the activity of MPO, as well. The anti-inflammatory effect of the composites was greater than those of pure GPs or curcumin.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0144-8617
1879-1344
1879-1344
DOI:10.1016/j.carbpol.2020.117142