Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in KrasG12D-driven tumors

We find that NUPR1, a stress-associated intrinsically disordered protein, induced droplet formation via liquid–liquid phase separation (LLPS). NUPR1-driven LLPS was crucial for the creation of NUPR1-dependent stress granules (SGs) in pancreatic cancer cells since genetic or pharmacological inhibitio...

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Bibliographic Details
Published in:	EMBO molecular medicine Vol. 16; no. 3; pp. 475 - 505
Main Authors:	Santofimia-Castaño, Patricia, Fraunhoffer, Nicolas, Liu, Xi, Bessone, Ivan Fernandez, di Magliano, Marina Pasca, Audebert, Stephane, Camoin, Luc, Estaras, Matias, Brenière, Manon, Modesti, Mauro, Lomberk, Gwen, Urrutia, Raul, Soubeyran, Philippe, Neira, Jose Luis, Iovanna, Juan
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 14.03.2024 Wiley Open Access Springer Nature
Subjects:	Biomedical and Life Sciences Biomedicine EMBO03 EMBO12 Kras Life Sciences Molecular Medicine NUPR1 Stress Granules Synthetic Lethality ZZW-115 Synthetic Lethality Kras ZZW-115 NUPR1 Stress Granules
ISSN:	1757-4684, 1757-4676, 1757-4684
Online Access:	Get full text
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