Necroptosis mediates the antineoplastic effects of the soluble fraction of polysaccharide from red wine in Walker-256 tumor-bearing rats
•Soluble fraction of polysaccharide extracted from cabernet franc wine has a complex mixture, with arabinogalactans, mannans and rhamnogalacturonans.•Soluble fraction of polysaccharide showed and expressive antineoplastic effects against the Walker-256 tumor in rats.•Soluble fraction of polysacchari...
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| Vydáno v: | Carbohydrate polymers Ročník 160; s. 123 - 133 |
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| Hlavní autoři: | , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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England
Elsevier Ltd
15.03.2017
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| ISSN: | 0144-8617, 1879-1344 |
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| Abstract | •Soluble fraction of polysaccharide extracted from cabernet franc wine has a complex mixture, with arabinogalactans, mannans and rhamnogalacturonans.•Soluble fraction of polysaccharide showed and expressive antineoplastic effects against the Walker-256 tumor in rats.•Soluble fraction of polysaccharide increased the tumor TNF-α production and activated the necroptosis pathway.•Soluble fraction of polysaccharide may be a potential therapy for cancers that are modulated by immune/inflammatory processes.
Polysaccharides are substances that modify the biological response to several stressors. The present study investigated the antitumor activity of the soluble fraction of polysaccharides (SFP), extracted from cabernet franc red wine, in Walker-256 tumor-bearing rats. The monosaccharide composition had a complex mixture, suggesting the presence of arabinoglactans, mannans, and pectins. Treatment with SFP (30 and 60mg/kg, oral) for 14days significantly reduced the tumor weight and volume compared with controls. Treatment with 60mg/kg SFP reduced blood monocytes and neutrophils, reduced the tumor activity of N-acetylglucosaminidase, myeloperoxidase, and nitric oxide, increased blood lymphocytes, and increased the levels of tumor necrosis factor α (TNF-α) in tumor tissue. Treatment with SFP also induced the expression of the cell necroptosis-related genes Rip1 and Rip3. The antineoplastic effect of SFP appears to be attributable to its action on the immune system by controlling the tumor microenvironment and stimulating TNF-α production, which may trigger the necroptosis pathway. |
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| AbstractList | Polysaccharides are substances that modify the biological response to several stressors. The present study investigated the antitumor activity of the soluble fraction of polysaccharides (SFP), extracted from cabernet franc red wine, in Walker-256 tumor-bearing rats. The monosaccharide composition had a complex mixture, suggesting the presence of arabinoglactans, mannans, and pectins. Treatment with SFP (30 and 60mg/kg, oral) for 14days significantly reduced the tumor weight and volume compared with controls. Treatment with 60mg/kg SFP reduced blood monocytes and neutrophils, reduced the tumor activity of N-acetylglucosaminidase, myeloperoxidase, and nitric oxide, increased blood lymphocytes, and increased the levels of tumor necrosis factor α (TNF-α) in tumor tissue. Treatment with SFP also induced the expression of the cell necroptosis-related genes Rip1 and Rip3. The antineoplastic effect of SFP appears to be attributable to its action on the immune system by controlling the tumor microenvironment and stimulating TNF-α production, which may trigger the necroptosis pathway. •Soluble fraction of polysaccharide extracted from cabernet franc wine has a complex mixture, with arabinogalactans, mannans and rhamnogalacturonans.•Soluble fraction of polysaccharide showed and expressive antineoplastic effects against the Walker-256 tumor in rats.•Soluble fraction of polysaccharide increased the tumor TNF-α production and activated the necroptosis pathway.•Soluble fraction of polysaccharide may be a potential therapy for cancers that are modulated by immune/inflammatory processes. Polysaccharides are substances that modify the biological response to several stressors. The present study investigated the antitumor activity of the soluble fraction of polysaccharides (SFP), extracted from cabernet franc red wine, in Walker-256 tumor-bearing rats. The monosaccharide composition had a complex mixture, suggesting the presence of arabinoglactans, mannans, and pectins. Treatment with SFP (30 and 60mg/kg, oral) for 14days significantly reduced the tumor weight and volume compared with controls. Treatment with 60mg/kg SFP reduced blood monocytes and neutrophils, reduced the tumor activity of N-acetylglucosaminidase, myeloperoxidase, and nitric oxide, increased blood lymphocytes, and increased the levels of tumor necrosis factor α (TNF-α) in tumor tissue. Treatment with SFP also induced the expression of the cell necroptosis-related genes Rip1 and Rip3. The antineoplastic effect of SFP appears to be attributable to its action on the immune system by controlling the tumor microenvironment and stimulating TNF-α production, which may trigger the necroptosis pathway. |
| Author | Klassen, Giseli Corso, Claudia Rita Queiroz-Telles, José Ederaldo dos Reis Livero, Francislaine A. Zampronio, Aleksander Roberto Acco, Alexandra Stipp, Maria Carolina Bezerra, Iglesias de Lacerda Ramos, Edneia A.S. Sassaki, Guilherme Lanzi Caillot, Adriana Rute Cordeiro Lomba, Luiz Alexandre |
| Author_xml | – sequence: 1 givenname: Maria Carolina surname: Stipp fullname: Stipp, Maria Carolina organization: Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 2 givenname: Iglesias de Lacerda surname: Bezerra fullname: Bezerra, Iglesias de Lacerda organization: Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 3 givenname: Claudia Rita surname: Corso fullname: Corso, Claudia Rita organization: Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 4 givenname: Francislaine A. surname: dos Reis Livero fullname: dos Reis Livero, Francislaine A. organization: Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 5 givenname: Luiz Alexandre surname: Lomba fullname: Lomba, Luiz Alexandre organization: Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 6 givenname: Adriana Rute Cordeiro surname: Caillot fullname: Caillot, Adriana Rute Cordeiro organization: Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 7 givenname: Aleksander Roberto surname: Zampronio fullname: Zampronio, Aleksander Roberto organization: Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 8 givenname: José Ederaldo surname: Queiroz-Telles fullname: Queiroz-Telles, José Ederaldo organization: Department of Medical Pathology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 9 givenname: Giseli surname: Klassen fullname: Klassen, Giseli organization: Department of Basic Pathology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 10 givenname: Edneia A.S. surname: Ramos fullname: Ramos, Edneia A.S. organization: Department of Basic Pathology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 11 givenname: Guilherme Lanzi surname: Sassaki fullname: Sassaki, Guilherme Lanzi organization: Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 12 givenname: Alexandra surname: Acco fullname: Acco, Alexandra email: aleacco@ufpr.br organization: Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28115086$$D View this record in MEDLINE/PubMed |
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| Keywords | red wine polysaccharide phosphate buffer (pH 6.5) ALT Walker-256 tumor buffered 10% formalin paraffin MPO ketamine hydrochloride p53 MTX NF-κB saline Triton X-100 0.1%, TMB 18.4 mM necroptosis p-nitrophenyl-N-acetyl-β-d-glucosamine Gapdh cabernet franc p-nitrofen ROS hematoxylin and eosin (HE) Bcl-2 NO immunomodulation dimethylformamide 8 Mlkl Vegf mRNA phosphate buffered saline (PBS, 16.5 mM phosphate, 137 mM NaCl, and 2.7 mM KCl) at pH 7.4 ethanol N-acetyl-β-d-glucosamine ANOVA xylazine hydrochloride FADD SFP TriZol Reagent AST metothrexate NaOAc Griess solution (0.1% N-1-naphthyl-tilediamine, 1% sulfanilamide in 5% H3PO4) TMB Rip-1 Rip-3 eTrypan blue, 2 M trifluoroacetic acid TNF-α NAG DNA ethylenediaminetetraacetic acid (EDTA) (0.5 M, pH 8.0) Bax xylol sodium acetate (NaOAc) HE Griess solution (0.1% N-1-naphthyl-tilediamine, 1% sulfanilamide in 5% HPO) |
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| Title | Necroptosis mediates the antineoplastic effects of the soluble fraction of polysaccharide from red wine in Walker-256 tumor-bearing rats |
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