Colorectal Cancer Patients Have Four Specific Bacterial Species in Oral and Gut Microbiota in Common—A Metagenomic Comparison with Healthy Subjects

Oral microbiota is reportedly associated with gut microbiota and influences colorectal cancer (CRC) progression; however, the details remain unclear. This study aimed to evaluate the role of oral microbiota in CRC progression. Fifty-two patients with CRC and 51 healthy controls were included. Saliva...

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Published in:Cancers Vol. 13; no. 13; p. 3332
Main Authors: Uchino, Yoshinori, Goto, Yuichi, Konishi, Yusuke, Tanabe, Kan, Toda, Hiroko, Wada, Masumi, Kita, Yoshiaki, Beppu, Mahiro, Mori, Shinichiro, Hijioka, Hiroshi, Otsuka, Takao, Natsugoe, Shoji, Hara, Eiji, Sugiura, Tsuyoshi
Format: Journal Article
Language:English
Published: Basel MDPI AG 02.07.2021
MDPI
Subjects:
Abundance
Bacteria
Bacterial infections
Cancer
Carcinogenesis
Colorectal cancer
Colorectal carcinoma
Comparative analysis
Discriminant analysis
Intestinal microflora
Laboratories
Metagenomics
Microbiota
Microorganisms
Mortality
Next-generation sequencing
Oral cavity
rRNA 16S
Saliva
Species
Taxonomy
United States > US
Japan
ISSN:2072-6694, 2072-6694
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Abstract Oral microbiota is reportedly associated with gut microbiota and influences colorectal cancer (CRC) progression; however, the details remain unclear. This study aimed to evaluate the role of oral microbiota in CRC progression. Fifty-two patients with CRC and 51 healthy controls were included. Saliva and stool samples were collected, and microbiota were evaluated using 16S rRNA analysis and next-generation sequencing. Comparative analysis was performed on both groups. Linear discriminant analysis effect size (LEfSe) revealed the presence of indigenous oral bacteria, such as Peptostreptococcus, Streptococcus, and Solobacterium spp., at a significantly higher relative abundance in saliva and stool samples of CRC patients compared with controls. Next, CRC patients were divided into early stage (Stage I, II; n = 26; 50%) and advanced stage (Stage III, IV; n = 26; 50%) disease. LEfSe revealed that S. moorei was present at a significantly higher relative abundance in the advanced-stage group compared with the early-stage group, again consistent for both saliva and stool samples. Among bacterial species with significantly higher relative abundance in CRC patients, P. stomatis, S. anginosus, S. koreensis, and S. moorei originated from the oral cavity, suggesting indigenous oral bacteria may have promoted initiation of CRC carcinogenesis. Furthermore, S. moorei may influence CRC progression.
AbstractList Oral microbiota is reportedly associated with gut microbiota and influences colorectal cancer (CRC) progression; however, the details remain unclear. This study aimed to evaluate the role of oral microbiota in CRC progression. Fifty-two patients with CRC and 51 healthy controls were included. Saliva and stool samples were collected, and microbiota were evaluated using 16S rRNA analysis and next-generation sequencing. Comparative analysis was performed on both groups. Linear discriminant analysis effect size (LEfSe) revealed the presence of indigenous oral bacteria, such as Peptostreptococcus, Streptococcus, and Solobacterium spp., at a significantly higher relative abundance in saliva and stool samples of CRC patients compared with controls. Next, CRC patients were divided into early stage (Stage I, II; n = 26; 50%) and advanced stage (Stage III, IV; n = 26; 50%) disease. LEfSe revealed that S. moorei was present at a significantly higher relative abundance in the advanced-stage group compared with the early-stage group, again consistent for both saliva and stool samples. Among bacterial species with significantly higher relative abundance in CRC patients, P. stomatis, S. anginosus, S. koreensis, and S. moorei originated from the oral cavity, suggesting indigenous oral bacteria may have promoted initiation of CRC carcinogenesis. Furthermore, S. moorei may influence CRC progression.Oral microbiota is reportedly associated with gut microbiota and influences colorectal cancer (CRC) progression; however, the details remain unclear. This study aimed to evaluate the role of oral microbiota in CRC progression. Fifty-two patients with CRC and 51 healthy controls were included. Saliva and stool samples were collected, and microbiota were evaluated using 16S rRNA analysis and next-generation sequencing. Comparative analysis was performed on both groups. Linear discriminant analysis effect size (LEfSe) revealed the presence of indigenous oral bacteria, such as Peptostreptococcus, Streptococcus, and Solobacterium spp., at a significantly higher relative abundance in saliva and stool samples of CRC patients compared with controls. Next, CRC patients were divided into early stage (Stage I, II; n = 26; 50%) and advanced stage (Stage III, IV; n = 26; 50%) disease. LEfSe revealed that S. moorei was present at a significantly higher relative abundance in the advanced-stage group compared with the early-stage group, again consistent for both saliva and stool samples. Among bacterial species with significantly higher relative abundance in CRC patients, P. stomatis, S. anginosus, S. koreensis, and S. moorei originated from the oral cavity, suggesting indigenous oral bacteria may have promoted initiation of CRC carcinogenesis. Furthermore, S. moorei may influence CRC progression.
Oral microbiota is reportedly associated with gut microbiota and influences colorectal cancer (CRC) progression; however, the details remain unclear. This study aimed to evaluate the role of oral microbiota in CRC progression. Fifty-two patients with CRC and 51 healthy controls were included. Saliva and stool samples were collected, and microbiota were evaluated using 16S rRNA analysis and next-generation sequencing. Comparative analysis was performed on both groups. Linear discriminant analysis effect size (LEfSe) revealed the presence of indigenous oral bacteria, such as Peptostreptococcus, Streptococcus, and Solobacterium spp., at a significantly higher relative abundance in saliva and stool samples of CRC patients compared with controls. Next, CRC patients were divided into early stage (Stage I, II; n = 26; 50%) and advanced stage (Stage III, IV; n = 26; 50%) disease. LEfSe revealed that S. moorei was present at a significantly higher relative abundance in the advanced-stage group compared with the early-stage group, again consistent for both saliva and stool samples. Among bacterial species with significantly higher relative abundance in CRC patients, P. stomatis, S. anginosus, S. koreensis, and S. moorei originated from the oral cavity, suggesting indigenous oral bacteria may have promoted initiation of CRC carcinogenesis. Furthermore, S. moorei may influence CRC progression.
Simple SummaryThe incidence of colorectal cancer (CRC) has been increasing in recent years, and the gut microbiota is nowadays considered to be involved in the progression of CRC. Recent studies have investigated the involvement of the oral microbiota in CRC development using saliva and stool samples. However, the details regarding how oral bacteria alter the gut microbiota and affect CRC carcinogenesis remain unclear. In the present study, we identified four bacterial species that may affect the carcinogenesis and progression of CRC. These microorganisms may be potential biomarkers in saliva for diagnosing CRC.AbstractOral microbiota is reportedly associated with gut microbiota and influences colorectal cancer (CRC) progression; however, the details remain unclear. This study aimed to evaluate the role of oral microbiota in CRC progression. Fifty-two patients with CRC and 51 healthy controls were included. Saliva and stool samples were collected, and microbiota were evaluated using 16S rRNA analysis and next-generation sequencing. Comparative analysis was performed on both groups. Linear discriminant analysis effect size (LEfSe) revealed the presence of indigenous oral bacteria, such as Peptostreptococcus, Streptococcus, and Solobacterium spp., at a significantly higher relative abundance in saliva and stool samples of CRC patients compared with controls. Next, CRC patients were divided into early stage (Stage I, II; n = 26; 50%) and advanced stage (Stage III, IV; n = 26; 50%) disease. LEfSe revealed that S. moorei was present at a significantly higher relative abundance in the advanced-stage group compared with the early-stage group, again consistent for both saliva and stool samples. Among bacterial species with significantly higher relative abundance in CRC patients, P. stomatis, S. anginosus, S. koreensis, and S. moorei originated from the oral cavity, suggesting indigenous oral bacteria may have promoted initiation of CRC carcinogenesis. Furthermore, S. moorei may influence CRC progression.
Author Konishi, Yusuke
Beppu, Mahiro
Mori, Shinichiro
Hijioka, Hiroshi
Toda, Hiroko
Hara, Eiji
Goto, Yuichi
Kita, Yoshiaki
Tanabe, Kan
Uchino, Yoshinori
Otsuka, Takao
Wada, Masumi
Natsugoe, Shoji
Sugiura, Tsuyoshi
AuthorAffiliation 2 Department of Molecular Microbiology, Research Institute for Microbial Diseases, Osaka University, 3-1, Yamadaoka, Suita, Osaka 565-0871, Japan; ykonishi@biken.osaka-u.ac.jp (Y.K.); ehara@biken.osaka-u.ac.jp (E.H.)
5 Department of Digestive Surgery, Imakiire General Hospital, 43-25, Korai, Kagoshima 890-0051, Japan; m.wada3373@imakiire.or.jp
1 Department of Maxillofacial Diagnostic and Surgical Science, Field of Oral and Maxillofacial Rehabilitation, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima 890-8544, Japan; k2309975@kadai.jp (Y.U.); ygoto@dent.kagoshima-u.ac.jp (Y.G.); mbeppu@dent.kagoshima-u.ac.jp (M.B.); zio@dent.kagoshima-u.ac.jp (H.H.)
6 Kajikionsen Hospital, 4714, Kida, Kajiki, Aira, Kagoshima 899-5241, Japan; s-natsugoe@gyokushoukai.com
3 Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical Sciences, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima 890-8520, Japan; k3113670@kadai.jp (
AuthorAffiliation_xml – name: 6 Kajikionsen Hospital, 4714, Kida, Kajiki, Aira, Kagoshima 899-5241, Japan; s-natsugoe@gyokushoukai.com
– name: 2 Department of Molecular Microbiology, Research Institute for Microbial Diseases, Osaka University, 3-1, Yamadaoka, Suita, Osaka 565-0871, Japan; ykonishi@biken.osaka-u.ac.jp (Y.K.); ehara@biken.osaka-u.ac.jp (E.H.)
– name: 3 Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical Sciences, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima 890-8520, Japan; k3113670@kadai.jp (K.T.); north-y@m.kufm.kagoshima-u.ac.jp (Y.K.); morishin@m3.kufm.kagoshima-u.ac.jp (S.M.); takao-o@kufm.kagoshima-u.ac.jp (T.O.)
– name: 4 Breast Surgery, Fujita Health University Hospital, 1-98, Dengakubo, Kutsukake, Toyoake, Aichi 470-1192, Japan; hiroko.toda@fujita-hu.ac.jp
– name: 1 Department of Maxillofacial Diagnostic and Surgical Science, Field of Oral and Maxillofacial Rehabilitation, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima 890-8544, Japan; k2309975@kadai.jp (Y.U.); ygoto@dent.kagoshima-u.ac.jp (Y.G.); mbeppu@dent.kagoshima-u.ac.jp (M.B.); zio@dent.kagoshima-u.ac.jp (H.H.)
– name: 5 Department of Digestive Surgery, Imakiire General Hospital, 43-25, Korai, Kagoshima 890-0051, Japan; m.wada3373@imakiire.or.jp
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Cites_doi 10.1002/ijc.31941
10.1093/aje/kwi049
10.1001/jamaoncol.2016.6374
10.1128/JCM.02525-10
10.1016/j.chom.2013.07.007
10.1186/s12866-016-0708-5
10.1097/QCO.0000000000000196
10.1002/ijc.30486
10.1186/gb-2011-12-6-r60
10.1101/gr.126516.111
10.1136/gutjnl-2018-316661
10.1371/journal.pone.0034242
10.1016/j.chom.2013.07.012
10.1002/iid3.266
10.1038/nature11234
10.3758/BRM.41.4.1149
10.1136/gutjnl-2015-309800
10.3322/caac.21492
10.1038/nature12347
10.1158/2159-8290.CD-16-0932
10.1158/0008-5472.CAN-13-1865
10.1038/nature11319
10.1007/s12010-021-03498-9
10.1007/s00284-019-01778-6
10.3389/fmicb.2017.02699
10.1159/000452757
10.1053/j.gastro.2014.12.035
10.1093/gastro/gox031
10.3758/BF03193146
10.1136/gutjnl-2015-310912
10.1053/j.gastro.2014.01.052
10.1038/s41587-019-0209-9
10.3748/wjg.v22.i2.557
10.1186/gb-2013-14-1-r1
10.1073/pnas.1000097107
10.1002/ijc.33596
10.1038/nrgastro.2012.220
10.1101/gr.126573.111
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References Russo (ref_11) 2018; 8
ref_14
Bray (ref_2) 2018; 68
Yoshimoto (ref_4) 2013; 499
ref_10
Bolyen (ref_8) 2019; 37
Lim (ref_27) 2019; 76
Nosho (ref_16) 2016; 22
Kostic (ref_21) 2013; 14
Iwauchi (ref_30) 2019; 7
Yang (ref_23) 2019; 144
Faul (ref_33) 2007; 39
Claesson (ref_35) 2012; 488
Odamaki (ref_29) 2016; 16
Tahara (ref_17) 2014; 74
Tuddenham (ref_38) 2015; 28
Yu (ref_7) 2017; 66
Hollister (ref_31) 2014; 146
Claesson (ref_32) 2011; 108
Loo (ref_5) 2017; 7
Segata (ref_9) 2011; 12
Babic (ref_24) 2017; 140
Pedersen (ref_26) 2011; 49
Zhou (ref_13) 2013; 14
Kostic (ref_19) 2011; 22
Wang (ref_25) 2021; 149
Mizoue (ref_36) 2005; 161
Castellarin (ref_18) 2011; 22
Liu (ref_12) 2020; 2020
Komiya (ref_6) 2018; 68
Song (ref_37) 2015; 148
Arnold (ref_1) 2017; 66
Masood (ref_28) 2016; 10
Zou (ref_40) 2018; 6
Mehta (ref_15) 2017; 3
Jobin (ref_20) 2012; 9
Faul (ref_34) 2009; 41
Siegel (ref_3) 2014; 64
Rubinstein (ref_22) 2013; 14
Chattopadhyay (ref_39) 2021; 193
References_xml – volume: 64
  start-page: 104
  year: 2014
  ident: ref_3
  article-title: Colorectal cancer statistics, 2014
  publication-title: CA: A Cancer J. Clin.
– volume: 144
  start-page: 2381
  year: 2019
  ident: ref_23
  article-title: Prospective study of oral microbiome and colorectal cancer risk in low-income and African American populations
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.31941
– volume: 161
  start-page: 338
  year: 2005
  ident: ref_36
  article-title: Dietary Patterns and Colorectal Adenomas in Japanese Men: The Self-Defense Forces Health Study
  publication-title: Am. J. Epidemiology
  doi: 10.1093/aje/kwi049
– volume: 3
  start-page: 921
  year: 2017
  ident: ref_15
  article-title: Association of Dietary Patterns With Risk of Colorectal Cancer Subtypes Classified by Fusobacterium nucleatum in Tumor Tissue
  publication-title: JAMA Oncol.
  doi: 10.1001/jamaoncol.2016.6374
– volume: 49
  start-page: 2766
  year: 2011
  ident: ref_26
  article-title: Solobacterium moorei Bacteremia: Identification, Antimicrobial Susceptibility, and Clinical Characteristics: Table 1
  publication-title: J. Clin. Microbiol.
  doi: 10.1128/JCM.02525-10
– volume: 14
  start-page: 207
  year: 2013
  ident: ref_21
  article-title: Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2013.07.007
– volume: 2020
  start-page: 7828392
  year: 2020
  ident: ref_12
  article-title: Study of the Relationship between Microbiome and Colorectal Cancer Susceptibility Using 16SrRNA Sequencing
  publication-title: BioMed. Res. Int.
– volume: 16
  start-page: 1
  year: 2016
  ident: ref_29
  article-title: Age-related changes in gut microbiota composition from newborn to centenarian: A cross-sectional study
  publication-title: BMC Microbiol.
  doi: 10.1186/s12866-016-0708-5
– volume: 28
  start-page: 464
  year: 2015
  ident: ref_38
  article-title: The intestinal microbiome and health
  publication-title: Curr. Opin. Infect. Dis.
  doi: 10.1097/QCO.0000000000000196
– volume: 140
  start-page: 646
  year: 2017
  ident: ref_24
  article-title: Periodontal disease, tooth loss and colorectal cancer risk: Results from the Nurses’ Health Study
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.30486
– volume: 12
  start-page: R60
  year: 2011
  ident: ref_9
  article-title: Metagenomic biomarker discovery and explanation
  publication-title: Genome Biol.
  doi: 10.1186/gb-2011-12-6-r60
– volume: 22
  start-page: 299
  year: 2011
  ident: ref_18
  article-title: Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma
  publication-title: Genome Res.
  doi: 10.1101/gr.126516.111
– volume: 68
  start-page: 1335
  year: 2018
  ident: ref_6
  article-title: Patients with colorectal cancer have identical strains of Fusobacterium nucleatum in their colorectal cancer and oral cavity
  publication-title: Gut
  doi: 10.1136/gutjnl-2018-316661
– ident: ref_14
  doi: 10.1371/journal.pone.0034242
– volume: 14
  start-page: 195
  year: 2013
  ident: ref_22
  article-title: Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/beta-catenin signaling via its FadA adhesin
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2013.07.012
– volume: 7
  start-page: 229
  year: 2019
  ident: ref_30
  article-title: Relationship between oral and gut microbiota in elderly people
  publication-title: Immunity, Inflamm. Dis.
  doi: 10.1002/iid3.266
– ident: ref_10
  doi: 10.1038/nature11234
– volume: 41
  start-page: 1149
  year: 2009
  ident: ref_34
  article-title: Statistical power analyses using G*Power 3.1: Tests for correlation and regression analyses
  publication-title: Behav. Res. Methods
  doi: 10.3758/BRM.41.4.1149
– volume: 66
  start-page: 70
  year: 2017
  ident: ref_7
  article-title: Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer
  publication-title: Gut
  doi: 10.1136/gutjnl-2015-309800
– volume: 68
  start-page: 394
  year: 2018
  ident: ref_2
  article-title: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
  publication-title: CA Cancer J. Clin.
  doi: 10.3322/caac.21492
– volume: 499
  start-page: 97
  year: 2013
  ident: ref_4
  article-title: Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
  publication-title: Nature
  doi: 10.1038/nature12347
– volume: 7
  start-page: 522
  year: 2017
  ident: ref_5
  article-title: Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity
  publication-title: Cancer Discov.
  doi: 10.1158/2159-8290.CD-16-0932
– volume: 74
  start-page: 1311
  year: 2014
  ident: ref_17
  article-title: Fusobacterium in Colonic Flora and Molecular Features of Colorectal Carcinoma
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-13-1865
– volume: 488
  start-page: 178
  year: 2012
  ident: ref_35
  article-title: Gut microbiota composition correlates with diet and health in the elderly
  publication-title: Nature
  doi: 10.1038/nature11319
– volume: 193
  start-page: 1780
  year: 2021
  ident: ref_39
  article-title: Exploring the Role of Gut Microbiome in Colon Cancer
  publication-title: Appl. Biochem. Biotechnol.
  doi: 10.1007/s12010-021-03498-9
– volume: 76
  start-page: 1531
  year: 2019
  ident: ref_27
  article-title: Streptococcus koreensis sp. nov., Isolated from Human Subgingival Dental Plaque of Periodontitis Lesion
  publication-title: Curr. Microbiol.
  doi: 10.1007/s00284-019-01778-6
– volume: 8
  start-page: 2699
  year: 2018
  ident: ref_11
  article-title: Preliminary Comparison of Oral and Intestinal Human Microbiota in Patients with Colorectal Cancer: A Pilot Study
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2017.02699
– volume: 10
  start-page: 769
  year: 2016
  ident: ref_28
  article-title: Colorectal Cancer Associated with Streptococcus anginosus Bacteremia and Liver Abscesses
  publication-title: Case Rep. Gastroenterol.
  doi: 10.1159/000452757
– volume: 148
  start-page: 1244
  year: 2015
  ident: ref_37
  article-title: Nutrients, Foods, and Colorectal Cancer Prevention
  publication-title: Gastroenterol.
  doi: 10.1053/j.gastro.2014.12.035
– volume: 6
  start-page: 1
  year: 2018
  ident: ref_40
  article-title: Dysbiosis of gut microbiota in promoting the development of colorectal cancer
  publication-title: Gastroenterol. Rep.
  doi: 10.1093/gastro/gox031
– volume: 39
  start-page: 175
  year: 2007
  ident: ref_33
  article-title: G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences
  publication-title: Behav. Res. Methods
  doi: 10.3758/BF03193146
– volume: 66
  start-page: 683
  year: 2017
  ident: ref_1
  article-title: Global patterns and trends in colorectal cancer incidence and mortality
  publication-title: Gut
  doi: 10.1136/gutjnl-2015-310912
– volume: 146
  start-page: 1449
  year: 2014
  ident: ref_31
  article-title: Compositional and Functional Features of the Gastrointestinal Microbiome and Their Effects on Human Health
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2014.01.052
– volume: 37
  start-page: 852
  year: 2019
  ident: ref_8
  article-title: Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2
  publication-title: Nat. Biotechnol.
  doi: 10.1038/s41587-019-0209-9
– volume: 22
  start-page: 557
  year: 2016
  ident: ref_16
  article-title: Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer
  publication-title: World J Gastroenterol.
  doi: 10.3748/wjg.v22.i2.557
– volume: 14
  start-page: R1
  year: 2013
  ident: ref_13
  article-title: Biogeography of the ecosystems of the healthy human body
  publication-title: Genome Biol.
  doi: 10.1186/gb-2013-14-1-r1
– volume: 108
  start-page: 4586
  year: 2011
  ident: ref_32
  article-title: Composition, variability, and temporal stability of the intestinal microbiota of the elderly
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1000097107
– volume: 149
  start-page: 925
  year: 2021
  ident: ref_25
  article-title: Alterations in the oral and gut microbiome of colorectal cancer patients and association with host clinical factors
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.33596
– volume: 9
  start-page: 694
  year: 2012
  ident: ref_20
  article-title: Colorectal cancer: CRC--all about microbial products and barrier function?
  publication-title: Nat. Rev. Gastroenterol. Hepatol.
  doi: 10.1038/nrgastro.2012.220
– volume: 22
  start-page: 292
  year: 2011
  ident: ref_19
  article-title: Genomic analysis identifies association of Fusobacterium with colorectal carcinoma
  publication-title: Genome Res.
  doi: 10.1101/gr.126573.111
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Snippet Oral microbiota is reportedly associated with gut microbiota and influences colorectal cancer (CRC) progression; however, the details remain unclear. This...
Simple SummaryThe incidence of colorectal cancer (CRC) has been increasing in recent years, and the gut microbiota is nowadays considered to be involved in the...
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StartPage 3332
SubjectTerms Abundance
Bacteria
Bacterial infections
Cancer
Carcinogenesis
Colorectal cancer
Colorectal carcinoma
Comparative analysis
Discriminant analysis
Intestinal microflora
Laboratories
Metagenomics
Microbiota
Microorganisms
Mortality
Next-generation sequencing
Oral cavity
rRNA 16S
Saliva
Species
Taxonomy
Title Colorectal Cancer Patients Have Four Specific Bacterial Species in Oral and Gut Microbiota in Common—A Metagenomic Comparison with Healthy Subjects
URI https://www.proquest.com/docview/2549280027
https://www.proquest.com/docview/2553524033
https://pubmed.ncbi.nlm.nih.gov/PMC8268706
Volume 13
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